FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2903972060> ?p ?o ?g. }

• W2903972060 endingPage "701" @default.
• W2903972060 startingPage "690" @default.
• W2903972060 abstract "Loganin, a major iridoid glycoside obtained from fruits of Cornus officinalis , possesses anti‐inflammatory, antitumor, antidiabetic, and osteoporosis prevention effects. Loganin has been linked to neuroprotection in several models of neurodegeneration, including Parkinson's disease (PD). However, mechanisms underlying the neuroprotective effects of loganin are still mostly unknown. Here, we demonstrated the protective effects of loganin against PD mimetic toxin 1‐methyl‐4‐phenylpyridinium (MPP + ) and the important roles of insulin‐like growth factor 1 receptor (IGF‐1R) and glucagon‐like peptide 1 receptor (GLP‐1R) in the neuroprotective mechanisms of loganin. In primary mesencephalic neuronal cultures treated with or without MPP + , loganin up‐regulated expressions of neurotrophic signals including IGF‐1R, GLP‐1R, p‐Akt, BDNF, and tyrosine hydroxylase. Loganin protected against MPP + ‐induced apoptosis by up‐regulating antiapoptotic protein and down‐regulating proapoptotic protein. Moreover, loganin attenuated MPP + ‐induced neurite damage via up‐regulation of GAP43 and down‐regulation of membrane‐RhoA/ROCK2/p‐LIMK/p‐cofilin. Loganin also attenuated MPP + ‐induced reactive oxygen species (ROS) production. However, both AG1024, an IGF‐1R antagonist, and exendin 9‐39, a GLP‐1R antagonist, attenuated the protective effects of loganin on MPP + ‐induced cytotoxicity, apoptosis, neurite length decrease, and ROS production. Our results suggest that loganin attenuates MPP + ‐induced apoptotic death, neurite damage, and oxidative stress through enhancement of neurotrophic signaling, activation of IGF‐1R/GLP‐1R, and inhibition of RhoA/ROCK pathway, providing the evidence that loganin possesses novel neuroprotective effects." @default.
• W2903972060 created "2018-12-22" @default.
• W2903972060 creator A5005286005 @default.
• W2903972060 creator A5023222658 @default.
• W2903972060 creator A5051472848 @default.
• W2903972060 creator A5062576111 @default.
• W2903972060 date "2018-12-16" @default.
• W2903972060 modified "2023-10-16" @default.
• W2903972060 title "The novel protective effects of loganin against 1‐methyl‐4‐phenylpyridinium‐induced neurotoxicity: Enhancement of neurotrophic signaling, activation of <scp>IGF‐1R/GLP‐1R</scp>, and inhibition of <scp>RhoA/ROCK</scp> pathway" @default.
• W2903972060 cites W1964299033 @default.
• W2903972060 cites W1964973011 @default.
• W2903972060 cites W1971389338 @default.
• W2903972060 cites W1989346488 @default.
• W2903972060 cites W1998026157 @default.
• W2903972060 cites W2002463596 @default.
• W2903972060 cites W2011497398 @default.
• W2903972060 cites W2013190303 @default.
• W2903972060 cites W2013223518 @default.
• W2903972060 cites W2030898494 @default.
• W2903972060 cites W2031075112 @default.
• W2903972060 cites W2032550816 @default.
• W2903972060 cites W2033711513 @default.
• W2903972060 cites W2037413425 @default.
• W2903972060 cites W2046454645 @default.
• W2903972060 cites W2046837117 @default.
• W2903972060 cites W2064426952 @default.
• W2903972060 cites W2069660332 @default.
• W2903972060 cites W2076316109 @default.
• W2903972060 cites W2079878023 @default.
• W2903972060 cites W2084948079 @default.
• W2903972060 cites W2095788394 @default.
• W2903972060 cites W2116240218 @default.
• W2903972060 cites W2151796501 @default.
• W2903972060 cites W2159113707 @default.
• W2903972060 cites W2164948885 @default.
• W2903972060 cites W2194319822 @default.
• W2903972060 cites W2239347425 @default.
• W2903972060 cites W2276988763 @default.
• W2903972060 cites W2404915204 @default.
• W2903972060 cites W2520005058 @default.
• W2903972060 cites W2522601866 @default.
• W2903972060 cites W2587017561 @default.
• W2903972060 cites W2593866083 @default.
• W2903972060 cites W2599105491 @default.
• W2903972060 cites W2749262658 @default.
• W2903972060 doi "https://doi.org/10.1002/ptr.6259" @default.
• W2903972060 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30556245" @default.
• W2903972060 hasPublicationYear "2018" @default.
• W2903972060 type Work @default.
• W2903972060 sameAs 2903972060 @default.
• W2903972060 citedByCount "18" @default.
• W2903972060 countsByYear W29039720602019 @default.
• W2903972060 countsByYear W29039720602020 @default.
• W2903972060 countsByYear W29039720602021 @default.
• W2903972060 countsByYear W29039720602022 @default.
• W2903972060 countsByYear W29039720602023 @default.
• W2903972060 crossrefType "journal-article" @default.
• W2903972060 hasAuthorship W2903972060A5005286005 @default.
• W2903972060 hasAuthorship W2903972060A5023222658 @default.
• W2903972060 hasAuthorship W2903972060A5051472848 @default.
• W2903972060 hasAuthorship W2903972060A5062576111 @default.
• W2903972060 hasConcept C113246987 @default.
• W2903972060 hasConcept C160539049 @default.
• W2903972060 hasConcept C170493617 @default.
• W2903972060 hasConcept C178790620 @default.
• W2903972060 hasConcept C179998833 @default.
• W2903972060 hasConcept C185592680 @default.
• W2903972060 hasConcept C202751555 @default.
• W2903972060 hasConcept C25498285 @default.
• W2903972060 hasConcept C2777093181 @default.
• W2903972060 hasConcept C2778436413 @default.
• W2903972060 hasConcept C2779491297 @default.
• W2903972060 hasConcept C29730261 @default.
• W2903972060 hasConcept C43617362 @default.
• W2903972060 hasConcept C55493867 @default.
• W2903972060 hasConcept C62478195 @default.
• W2903972060 hasConcept C86803240 @default.
• W2903972060 hasConcept C98274493 @default.
• W2903972060 hasConceptScore W2903972060C113246987 @default.
• W2903972060 hasConceptScore W2903972060C160539049 @default.
• W2903972060 hasConceptScore W2903972060C170493617 @default.
• W2903972060 hasConceptScore W2903972060C178790620 @default.
• W2903972060 hasConceptScore W2903972060C179998833 @default.
• W2903972060 hasConceptScore W2903972060C185592680 @default.
• W2903972060 hasConceptScore W2903972060C202751555 @default.
• W2903972060 hasConceptScore W2903972060C25498285 @default.
• W2903972060 hasConceptScore W2903972060C2777093181 @default.
• W2903972060 hasConceptScore W2903972060C2778436413 @default.
• W2903972060 hasConceptScore W2903972060C2779491297 @default.
• W2903972060 hasConceptScore W2903972060C29730261 @default.
• W2903972060 hasConceptScore W2903972060C43617362 @default.
• W2903972060 hasConceptScore W2903972060C55493867 @default.
• W2903972060 hasConceptScore W2903972060C62478195 @default.
• W2903972060 hasConceptScore W2903972060C86803240 @default.
• W2903972060 hasConceptScore W2903972060C98274493 @default.
• W2903972060 hasFunder F4320322795 @default.
• W2903972060 hasIssue "3" @default.
• W2903972060 hasLocation W29039720601 @default.

• next