FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904003882> ?p ?o ?g. }

• W2904003882 abstract "Activation of resident microglia accompanies every known form of neurodegeneration, but the involvement of peripheral monocytes that extravasate and rapidly transform into microglia-like macrophages within the central nervous system during degeneration is far less clear. Using a combination of in vivo ocular imaging, flow cytometry, and immunohistochemistry, we investigated the response of infiltrating cells in a light-inducible mouse model of photoreceptor degeneration. Within 24 h, resident microglia became activated and began migrating to the site of degeneration. Retinal expression of CCL2 increased just prior to a transient period of CCR2+ cell extravasation from the retinal vasculature. Proliferation of microglia and monocytes occurred concurrently; however, there was no indication of proliferation in either population until 72–96 h after neurodegeneration began. Eliminating CCL2-CCR2 signaling blocked monocyte recruitment, but did not alter the extent of retinal degeneration. These results demonstrate that the immune response to photoreceptor degeneration includes both resident microglia and monocytes, even at very early times. Surprisingly, preventing monocyte infiltration did not block neurodegeneration, suggesting that in this model, degeneration is limited by cell clearance from other phagocytes or by the timing of intrinsic cell death programs. These results show monocyte involvement is not limited to disease states that overwhelm or deplete the resident microglial population and that interventions focused on modulating the peripheral immune system are not universally beneficial for staving off degeneration." @default.
• W2904003882 created "2018-12-22" @default.
• W2904003882 creator A5003332286 @default.
• W2904003882 creator A5037070406 @default.
• W2904003882 creator A5044266730 @default.
• W2904003882 creator A5060121865 @default.
• W2904003882 creator A5081788525 @default.
• W2904003882 creator A5082604512 @default.
• W2904003882 date "2018-12-01" @default.
• W2904003882 modified "2023-10-17" @default.
• W2904003882 title "Monocyte infiltration rather than microglia proliferation dominates the early immune response to rapid photoreceptor degeneration" @default.
• W2904003882 cites W1481967758 @default.
• W2904003882 cites W1964245315 @default.
• W2904003882 cites W1968659926 @default.
• W2904003882 cites W1970723405 @default.
• W2904003882 cites W1977361305 @default.
• W2904003882 cites W1993755473 @default.
• W2904003882 cites W1996024251 @default.
• W2904003882 cites W1996690280 @default.
• W2904003882 cites W1999419270 @default.
• W2904003882 cites W2000919900 @default.
• W2904003882 cites W2003674452 @default.
• W2904003882 cites W2004070471 @default.
• W2904003882 cites W2009230499 @default.
• W2904003882 cites W2015141049 @default.
• W2904003882 cites W2025981538 @default.
• W2904003882 cites W2029906813 @default.
• W2904003882 cites W2057185572 @default.
• W2904003882 cites W2058669152 @default.
• W2904003882 cites W2067118161 @default.
• W2904003882 cites W2071927808 @default.
• W2904003882 cites W2072402974 @default.
• W2904003882 cites W2089573422 @default.
• W2904003882 cites W2104301336 @default.
• W2904003882 cites W2119324374 @default.
• W2904003882 cites W2124392720 @default.
• W2904003882 cites W2124928608 @default.
• W2904003882 cites W2140309418 @default.
• W2904003882 cites W2148185920 @default.
• W2904003882 cites W2151003930 @default.
• W2904003882 cites W2158564443 @default.
• W2904003882 cites W2159555560 @default.
• W2904003882 cites W2169073576 @default.
• W2904003882 cites W2201019342 @default.
• W2904003882 cites W2218055291 @default.
• W2904003882 cites W2265779583 @default.
• W2904003882 cites W2290890702 @default.
• W2904003882 cites W2306408644 @default.
• W2904003882 cites W2336534940 @default.
• W2904003882 cites W2435010421 @default.
• W2904003882 cites W2512881232 @default.
• W2904003882 cites W2555502454 @default.
• W2904003882 cites W2607751027 @default.
• W2904003882 cites W2622806731 @default.
• W2904003882 cites W2712068521 @default.
• W2904003882 cites W2735217968 @default.
• W2904003882 cites W2765080153 @default.
• W2904003882 cites W2766931716 @default.
• W2904003882 cites W2773175183 @default.
• W2904003882 cites W2800167901 @default.
• W2904003882 cites W4232005894 @default.
• W2904003882 doi "https://doi.org/10.1186/s12974-018-1365-4" @default.
• W2904003882 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7659426" @default.
• W2904003882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30553275" @default.
• W2904003882 hasPublicationYear "2018" @default.
• W2904003882 type Work @default.
• W2904003882 sameAs 2904003882 @default.
• W2904003882 citedByCount "40" @default.
• W2904003882 countsByYear W29040038822019 @default.
• W2904003882 countsByYear W29040038822020 @default.
• W2904003882 countsByYear W29040038822021 @default.
• W2904003882 countsByYear W29040038822022 @default.
• W2904003882 countsByYear W29040038822023 @default.
• W2904003882 crossrefType "journal-article" @default.
• W2904003882 hasAuthorship W2904003882A5003332286 @default.
• W2904003882 hasAuthorship W2904003882A5037070406 @default.
• W2904003882 hasAuthorship W2904003882A5044266730 @default.
• W2904003882 hasAuthorship W2904003882A5060121865 @default.
• W2904003882 hasAuthorship W2904003882A5081788525 @default.
• W2904003882 hasAuthorship W2904003882A5082604512 @default.
• W2904003882 hasBestOaLocation W29040038821 @default.
• W2904003882 hasConcept C101666144 @default.
• W2904003882 hasConcept C12823836 @default.
• W2904003882 hasConcept C13373296 @default.
• W2904003882 hasConcept C142724271 @default.
• W2904003882 hasConcept C169760540 @default.
• W2904003882 hasConcept C203014093 @default.
• W2904003882 hasConcept C206615009 @default.
• W2904003882 hasConcept C2776914184 @default.
• W2904003882 hasConcept C2776925932 @default.
• W2904003882 hasConcept C2777093970 @default.
• W2904003882 hasConcept C2779134260 @default.
• W2904003882 hasConcept C2779830541 @default.
• W2904003882 hasConcept C2781040256 @default.
• W2904003882 hasConcept C2781184567 @default.
• W2904003882 hasConcept C2908647359 @default.
• W2904003882 hasConcept C71924100 @default.
• W2904003882 hasConcept C86803240 @default.
• W2904003882 hasConcept C8891405 @default.
• W2904003882 hasConcept C95444343 @default.

• next