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• W2904004727 abstract "Chronic active multiple sclerosis lesions, characterized by a hyperintense rim of iron-enriched, activated microglia and macrophages, have been linked to greater tissue damage. Post-mortem studies have determined that chronic active lesions are primarily related to the later stages of multiple sclerosis; however, the occurrence of these lesions, and their relationship to earlier disease stages may be greatly underestimated. Detection of chronic active lesions across the patient spectrum of multiple sclerosis requires a validated imaging tool to accurately identify lesions with persistent inflammation. Quantitative susceptibility mapping provides efficient in vivo quantification of susceptibility changes related to iron deposition and the potential to identify lesions harbouring iron-laden inflammatory cells. The PET tracer 11C-PK11195 targets the translocator protein expressed by activated microglia and infiltrating macrophages. Accordingly, this study aimed to validate that lesions with a hyperintense rim on quantitative susceptibility mapping from both relapsing and progressive patients demonstrate a higher level of innate immune activation as measured on 11C-PK11195 PET. Thirty patients were enrolled in this study, 24 patients had relapsing remitting multiple sclerosis, six had progressive multiple sclerosis, and all patients had concomitant MRI with a gradient echo sequence and PET with 11C-PK11195. A total of 406 chronic lesions were detected, and 43 chronic lesions with a hyperintense rim on quantitative susceptibility mapping were identified as rim+ lesions. Susceptibility (relative to CSF) was higher in rim+ (2.42 ± 17.45 ppb) compared to rim- lesions (-14.6 ± 19.3 ppb, P < 0.0001). Among rim+ lesions, susceptibility within the rim (20.04 ± 14.28 ppb) was significantly higher compared to the core (-5.49 ± 14.44 ppb, P < 0.0001), consistent with the presence of iron. In a mixed-effects model, 11C-PK11195 uptake, representing activated microglia/macrophages, was higher in rim+ lesions compared to rim- lesions (P = 0.015). Validating our in vivo imaging results, multiple sclerosis brain slabs were imaged with quantitative susceptibility mapping and processed for immunohistochemistry. These results showed a positive translocator protein signal throughout the expansive hyperintense border of rim+ lesions, which co-localized with iron containing CD68+ microglia and macrophages. In conclusion, this study provides evidence that suggests that a hyperintense rim on quantitative susceptibility measure within a chronic lesion is a correlate for persistent inflammatory activity and that these lesions can be identified in the relapsing patients. Utilizing quantitative susceptibility measure to differentiate chronic multiple sclerosis lesion subtypes, especially chronic active lesions, would provide a method to assess the impact of these lesions on disease progression." @default.
• W2904004727 created "2018-12-22" @default.
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• W2904004727 date "2018-12-15" @default.
• W2904004727 modified "2023-10-17" @default.
• W2904004727 title "Quantitative susceptibility mapping identifies inflammation in a subset of chronic multiple sclerosis lesions" @default.
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• W2904004727 cites W1763205699 @default.
• W2904004727 cites W1828576284 @default.
• W2904004727 cites W1830455541 @default.
• W2904004727 cites W1848702082 @default.
• W2904004727 cites W1978094617 @default.
• W2904004727 cites W1979911585 @default.
• W2904004727 cites W1981155372 @default.
• W2904004727 cites W1986728683 @default.
• W2904004727 cites W1989201276 @default.
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• W2904004727 cites W1995089232 @default.
• W2904004727 cites W2000029267 @default.
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• W2904004727 cites W2039905470 @default.
• W2904004727 cites W2049703902 @default.
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• W2904004727 cites W2136032145 @default.
• W2904004727 cites W2137519405 @default.
• W2904004727 cites W2142921985 @default.
• W2904004727 cites W2148602027 @default.
• W2904004727 cites W2150899738 @default.
• W2904004727 cites W2151759656 @default.
• W2904004727 cites W2154189431 @default.
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• W2904004727 cites W2264661966 @default.
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• W2904004727 cites W2336862132 @default.
• W2904004727 cites W2411634129 @default.
• W2904004727 cites W2419062639 @default.
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• W2904004727 doi "https://doi.org/10.1093/brain/awy296" @default.
• W2904004727 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6308309" @default.
• W2904004727 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30561514" @default.
• W2904004727 hasPublicationYear "2018" @default.
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