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• W2904005302 abstract "Background Medication-related osteonecrosis of the jaws (MRONJ), which causes exposed bone in the maxillofacial region, persisted for 8 weeks in a patient who was receiving a bone-modulating agent.1 Multiple myeloma (MM) is a hematologic cancer that can cause bone disease. Therefore, a potent bisphosphonate is used to control bone metastasis, but one of its adverse effects is MRONJ. Previous studies that investigated risk factors associated with MRONJ were done in patients with different hematologic conditions, where the underlining condition might affect the result.2-4 Objective The aim of this study was to evaluate the possible risk factors associated with MRONJ in patients with MM. Materials and Methods The institutional review board approved the study. We reviewed the medical charts, including digital radiographs, of 116 patients with MM, 16 of whom had developed MRONJ; these patients had attended the oral medicine clinic at the University of Florida College of Dentistry between 2011 and 2015. The following information was retrieved: age, gender, smoking, type and duration of bisphosphonate pressure treatment, and periodontal status. Periodontal bone loss was measured from a digital pantomograph as a percentage of missing bone at the mesial and distal surfaces of each tooth. These measurements were averaged to yield a single mean bone loss score for each patient.5 Using radiographs, in place of clinical examination, to determine periodontal bone loss has been validated in earlier studies.6,7 The variables predictive of MRONJ development were calculated by using SPSS software (SPSS Inc., Chicago, IL). Results Patients with MRONJ had significantly higher percentage of bone loss (odds ratio [OR] 6.06; P < .001). Patients who had greater than 15 missing teeth were at higher risk of MRONJ (OR 5.7; P = .005). No statically significant association was found with regard to the other variables. Conclusions Tooth loss and advanced bone loss are significant risk factors of MRONJ in patients with MM. This study was limited to radiologic examination, and no clinical periodontal examination was performed. The usefulness of radiographs can be limited by the technique used because some can cause distortion and affect the measurements. Medication-related osteonecrosis of the jaws (MRONJ), which causes exposed bone in the maxillofacial region, persisted for 8 weeks in a patient who was receiving a bone-modulating agent.1 Multiple myeloma (MM) is a hematologic cancer that can cause bone disease. Therefore, a potent bisphosphonate is used to control bone metastasis, but one of its adverse effects is MRONJ. Previous studies that investigated risk factors associated with MRONJ were done in patients with different hematologic conditions, where the underlining condition might affect the result.2-4 The aim of this study was to evaluate the possible risk factors associated with MRONJ in patients with MM. The institutional review board approved the study. We reviewed the medical charts, including digital radiographs, of 116 patients with MM, 16 of whom had developed MRONJ; these patients had attended the oral medicine clinic at the University of Florida College of Dentistry between 2011 and 2015. The following information was retrieved: age, gender, smoking, type and duration of bisphosphonate pressure treatment, and periodontal status. Periodontal bone loss was measured from a digital pantomograph as a percentage of missing bone at the mesial and distal surfaces of each tooth. These measurements were averaged to yield a single mean bone loss score for each patient.5 Using radiographs, in place of clinical examination, to determine periodontal bone loss has been validated in earlier studies.6,7 The variables predictive of MRONJ development were calculated by using SPSS software (SPSS Inc., Chicago, IL). Patients with MRONJ had significantly higher percentage of bone loss (odds ratio [OR] 6.06; P < .001). Patients who had greater than 15 missing teeth were at higher risk of MRONJ (OR 5.7; P = .005). No statically significant association was found with regard to the other variables. Tooth loss and advanced bone loss are significant risk factors of MRONJ in patients with MM. This study was limited to radiologic examination, and no clinical periodontal examination was performed. The usefulness of radiographs can be limited by the technique used because some can cause distortion and affect the measurements." @default.
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• W2904005302 date "2019-01-01" @default.
• W2904005302 modified "2023-09-26" @default.
• W2904005302 title "CLINICAL AND RADIOGRAPHIC VARIABLES ASSOCIATED WITH MEDICATION-RELATED OSTEONECROSIS OF THE JAW (MRONJ) IN PATIENTS WITH MULTIPLE MYELOMA—A RETROSPECTIVE STUDY" @default.
• W2904005302 doi "https://doi.org/10.1016/j.oooo.2018.07.050" @default.
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