FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904006202> ?p ?o ?g. }

• W2904006202 endingPage "S1051" @default.
• W2904006202 startingPage "S1051" @default.
• W2904006202 abstract "Due to the advent of molecular targeted therapy, the therapeutic landscape of advanced NSCLC with certain driver mutations has been changed substantially. Local consolidation therapy with surgery or radiotherapy in combination with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) is believed to achieve longer progression-free survival (PFS) for stage IV NSCLC patients with oligometastases. We investigated whether primary tumor resection in non-small cell lung cancer (NSCLC) patients with ipsilateral pleural dissemination could achieve more clinical benefit during first-line targeted therapy. Patients with an initial diagnosis of stage IVa NSCLC who had ipsilateral pleural dissemination and received first-line EGFR-TKIs were included. Overall survival (OS) and progression-free survival (PFS) were analyzed. Median (m)PFS was the primary endpoint. Patients were divided into three groups: 17 cases in the palliative resection (PR) group, 15 in the video-assisted thoracoscopic surgery (VATS) biopsy (VB) group, and 56 in the pneumocentesis (P) group. Median (m)PFS and mOS for the entire cohort were 15.7 and 37.5 months, respectively. MPFS for PR group was 27.4 months, significantly longer than that for the VB and P groups (15.1 months and 13.3 months, respectively (p<0.05)). The mPFS for patients with primary tumors ≤ 3.5 cm was 21.4 months, compared with 13.3 months for tumors >3.5 cm (p=0.017). In PFS multivariate analysis, primary tumor length (HR 1.682) and treatment modality (HR 0.795) were possible independent prognostic factors. The mOS and 5-year OS rate for the PR group was 48.0 months and 44.8%, respectively, compared with 37.5 months and 11.3%, respectively, for patients whose tumors were not resected (p=0.130). For patients who received subsequent targeted therapy (n=30) after first progression, mOS and 5-year OS rate were 52.9 months and 48.8%, respectively, compared with 29.6 months and 2.9%, respectively, for patients who received chemotherapy (n=45) (p=0.000). In further OS multivariate analysis, subsequent treatment was the only independent prognostic factor (HR 5.873, 95% CI, 2.694–12.804, p=0.000). Our study demonstrates, for the first time, a role for palliative resection in NSCLC patients with ipsilateral pleural dissemination treated with first-line EGFR-TKIs that results in improved PFS and OS. Subsequent targeted therapy after first progression could achieve a better OS compared with chemotherapy." @default.
• W2904006202 created "2018-12-22" @default.
• W2904006202 creator A5031262862 @default.
• W2904006202 creator A5043962836 @default.
• W2904006202 date "2018-12-01" @default.
• W2904006202 modified "2023-09-26" @default.
• W2904006202 title "P002 Surgical Resection Improves the Survival of NSCLC Patients with Pleural Metastasis Treated with First-Line EGFR-TKIs" @default.
• W2904006202 doi "https://doi.org/10.1016/j.jtho.2018.10.027" @default.
• W2904006202 hasPublicationYear "2018" @default.
• W2904006202 type Work @default.
• W2904006202 sameAs 2904006202 @default.
• W2904006202 citedByCount "0" @default.
• W2904006202 crossrefType "journal-article" @default.
• W2904006202 hasAuthorship W2904006202A5031262862 @default.
• W2904006202 hasAuthorship W2904006202A5043962836 @default.
• W2904006202 hasBestOaLocation W29040062021 @default.
• W2904006202 hasConcept C121608353 @default.
• W2904006202 hasConcept C126322002 @default.
• W2904006202 hasConcept C141071460 @default.
• W2904006202 hasConcept C143998085 @default.
• W2904006202 hasConcept C146357865 @default.
• W2904006202 hasConcept C151730666 @default.
• W2904006202 hasConcept C168563851 @default.
• W2904006202 hasConcept C203092338 @default.
• W2904006202 hasConcept C2776256026 @default.
• W2904006202 hasConcept C2779013556 @default.
• W2904006202 hasConcept C2780283643 @default.
• W2904006202 hasConcept C2780739268 @default.
• W2904006202 hasConcept C2781230642 @default.
• W2904006202 hasConcept C3019894029 @default.
• W2904006202 hasConcept C71924100 @default.
• W2904006202 hasConcept C86803240 @default.
• W2904006202 hasConceptScore W2904006202C121608353 @default.
• W2904006202 hasConceptScore W2904006202C126322002 @default.
• W2904006202 hasConceptScore W2904006202C141071460 @default.
• W2904006202 hasConceptScore W2904006202C143998085 @default.
• W2904006202 hasConceptScore W2904006202C146357865 @default.
• W2904006202 hasConceptScore W2904006202C151730666 @default.
• W2904006202 hasConceptScore W2904006202C168563851 @default.
• W2904006202 hasConceptScore W2904006202C203092338 @default.
• W2904006202 hasConceptScore W2904006202C2776256026 @default.
• W2904006202 hasConceptScore W2904006202C2779013556 @default.
• W2904006202 hasConceptScore W2904006202C2780283643 @default.
• W2904006202 hasConceptScore W2904006202C2780739268 @default.
• W2904006202 hasConceptScore W2904006202C2781230642 @default.
• W2904006202 hasConceptScore W2904006202C3019894029 @default.
• W2904006202 hasConceptScore W2904006202C71924100 @default.
• W2904006202 hasConceptScore W2904006202C86803240 @default.
• W2904006202 hasIssue "12" @default.
• W2904006202 hasLocation W29040062021 @default.
• W2904006202 hasOpenAccess W2904006202 @default.
• W2904006202 hasPrimaryLocation W29040062021 @default.
• W2904006202 hasRelatedWork W1960864063 @default.
• W2904006202 hasRelatedWork W2037355330 @default.
• W2904006202 hasRelatedWork W2055887390 @default.
• W2904006202 hasRelatedWork W2290972925 @default.
• W2904006202 hasRelatedWork W2387455091 @default.
• W2904006202 hasRelatedWork W2729289325 @default.
• W2904006202 hasRelatedWork W2734557114 @default.
• W2904006202 hasRelatedWork W2902679640 @default.
• W2904006202 hasRelatedWork W3171492215 @default.
• W2904006202 hasRelatedWork W4223523856 @default.
• W2904006202 hasVolume "13" @default.
• W2904006202 isParatext "false" @default.
• W2904006202 isRetracted "false" @default.
• W2904006202 magId "2904006202" @default.
• W2904006202 workType "article" @default.