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- W2904006614 abstract "Hypertensive target organ damage (TOD) is associated with increased risk for cardiovascular (CV) events. Ambulatory blood pressure (ABP) allows better prediction of TOD than clinic BP in adults, but data in youth are lacking. We aimed to determine if BP phenotype, based on a combination of clinic BP and ABP, predicts underlying CV TOD in otherwise healthy adolescents. We evaluated clinic BP (mean of 6 auscultatory BP’s), ABP (Spacelabs OnTrak), left ventricular mass index (LVMI), pulse wave velocity (PWV), diastolic function (E/e’), and systolic function (longitudinal strain) in 244 adolescents (median age 15.7 yrs, 63% white, 54% male). Clinic HTN was defined according to pediatric guidelines, and ambulatory HTN was defined as wake systolic BP > 95 th percentile for sex and height. General linear models were used to evaluate associations between BP phenotype and TOD. Normal BP phenotype was found in 162 participants (66%), while 44 (18%), 16 (7%), and 22 (9%) had white coat (WCH), masked (MH), and ambulatory (AH) HTN, respectively. Participants with an abnormal BP phenotype had higher LVMI and PWV compared to those with normal BP (table). Participants with AH also had significantly higher PWV than those with WCH or MH. Adolescents with MH or AH had worse diastolic function (higher E/e’) compared to those with normal BP or WCH. Only participants with AH had significantly worse systolic function (less negative strain) compared to those with normal BP; there was no significant difference in strain among subjects with normal BP, WCH and MH. In conclusion, ABPM improves TOD risk stratification in adolescents evaluated for HTN." @default.
- W2904006614 created "2018-12-22" @default.
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- W2904006614 date "2018-09-01" @default.
- W2904006614 modified "2023-09-27" @default.
- W2904006614 title "Abstract P391: Ambulatory Blood Pressure Phenotypes and Cardiovascular Target Organ Damage in Adolescents: The SHIP AHOY Study" @default.
- W2904006614 doi "https://doi.org/10.1161/hyp.72.suppl_1.p391" @default.
- W2904006614 hasPublicationYear "2018" @default.
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