FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904009992> ?p ?o ?g. }

• W2904009992 abstract "Glucose regulated protein 78 (GRP78) is a resident chaperone of the endoplasmic reticulum and a master regulator of the unfolded protein response under physiological and pathological cell stress conditions. GRP78 is overexpressed in many cancers, regulating a variety of signaling pathways associated with tumor initiation, proliferation, adhesion and invasion which contributes to metastatic spread. GRP78 can also regulate cell survival and apoptotic pathways to alter responsiveness to anticancer drugs. Tumors that reside in or metastasize to the bone and bone marrow (BM) space can develop pro-survival signals through their direct adhesive interactions with stromal elements of this niche thereby resisting the cytotoxic effects of drug treatment. In this study, we report a direct correlation between GRP78 and the adhesion molecule N-cadherin (N-cad), known to play a critical role in the adhesive interactions of multiple myeloma and metastatic prostate cancer with the bone microenvironment.N-cad expression levels (transcription and protein) were evaluated upon siRNA mediated silencing of GRP78 in the MM.1S multiple myeloma and the PC3 metastatic prostate cancer cell lines. Furthermore, we evaluated the effects of GRP78 knockdown (KD) on epithelial-mesenchymal (EMT) transition markers, morphological changes and adhesion of PC3 cells.GRP78 KD led to concomitant downregulation of N-cad in both tumors types. In PC3 cells, GRP78 KD significantly decreased E-cadherin (E-cad) expression likely associated with the induction in TGF-β1 expression. Furthermore, GRP78 KD also triggered drastic changes in PC3 cells morphology and decreased their adhesion to osteoblasts (OSB) dependent, in part, to the reduced N-cad expression.This work implicates GRP78 as a modulator of cell adhesion markers in MM and PCa. Our results may have clinical implications underscoring GRP78 as a potential therapeutic target to reduce the adhesive nature of metastatic tumors to the bone niche." @default.
• W2904009992 created "2018-12-22" @default.
• W2904009992 creator A5003072750 @default.
• W2904009992 creator A5010280256 @default.
• W2904009992 creator A5013268190 @default.
• W2904009992 creator A5014591774 @default.
• W2904009992 creator A5016292208 @default.
• W2904009992 creator A5023932305 @default.
• W2904009992 creator A5028951571 @default.
• W2904009992 creator A5076479300 @default.
• W2904009992 date "2018-12-01" @default.
• W2904009992 modified "2023-10-14" @default.
• W2904009992 title "GRP78 modulates cell adhesion markers in prostate Cancer and multiple myeloma cell lines" @default.
• W2904009992 cites W1500493219 @default.
• W2904009992 cites W1512242063 @default.
• W2904009992 cites W1564849382 @default.
• W2904009992 cites W1598232851 @default.
• W2904009992 cites W1681742074 @default.
• W2904009992 cites W1760215417 @default.
• W2904009992 cites W1824211826 @default.
• W2904009992 cites W1890354534 @default.
• W2904009992 cites W1921751791 @default.
• W2904009992 cites W1939550743 @default.
• W2904009992 cites W1966819064 @default.
• W2904009992 cites W1977918192 @default.
• W2904009992 cites W1984647773 @default.
• W2904009992 cites W1988669425 @default.
• W2904009992 cites W1990678347 @default.
• W2904009992 cites W1994138076 @default.
• W2904009992 cites W1997219360 @default.
• W2904009992 cites W1999132074 @default.
• W2904009992 cites W2000084288 @default.
• W2904009992 cites W2015705955 @default.
• W2904009992 cites W2018978055 @default.
• W2904009992 cites W2026642838 @default.
• W2904009992 cites W2031943423 @default.
• W2904009992 cites W2036488841 @default.
• W2904009992 cites W2047244099 @default.
• W2904009992 cites W2055531243 @default.
• W2904009992 cites W2061573300 @default.
• W2904009992 cites W2076056289 @default.
• W2904009992 cites W2076539042 @default.
• W2904009992 cites W2084382584 @default.
• W2904009992 cites W2087367170 @default.
• W2904009992 cites W2089522070 @default.
• W2904009992 cites W2091341678 @default.
• W2904009992 cites W2091613795 @default.
• W2904009992 cites W2095647593 @default.
• W2904009992 cites W2097971577 @default.
• W2904009992 cites W2099280507 @default.
• W2904009992 cites W2101136044 @default.
• W2904009992 cites W2102298863 @default.
• W2904009992 cites W2104151011 @default.
• W2904009992 cites W2108975092 @default.
• W2904009992 cites W2113054276 @default.
• W2904009992 cites W2115610840 @default.
• W2904009992 cites W2124580184 @default.
• W2904009992 cites W2137005750 @default.
• W2904009992 cites W2141005335 @default.
• W2904009992 cites W2149951991 @default.
• W2904009992 cites W2151048523 @default.
• W2904009992 cites W2153628853 @default.
• W2904009992 cites W2154639719 @default.
• W2904009992 cites W2155010407 @default.
• W2904009992 cites W2157219248 @default.
• W2904009992 cites W2166372230 @default.
• W2904009992 cites W2170420350 @default.
• W2904009992 cites W2176586413 @default.
• W2904009992 cites W2176663792 @default.
• W2904009992 cites W2183877552 @default.
• W2904009992 cites W2339351282 @default.
• W2904009992 cites W2341639977 @default.
• W2904009992 cites W2567127052 @default.
• W2904009992 cites W2581799543 @default.
• W2904009992 cites W2588938963 @default.
• W2904009992 cites W2606527259 @default.
• W2904009992 cites W2740092696 @default.
• W2904009992 cites W2749183937 @default.
• W2904009992 cites W2765684059 @default.
• W2904009992 cites W2782330970 @default.
• W2904009992 cites W303546134 @default.
• W2904009992 doi "https://doi.org/10.1186/s12885-018-5178-8" @default.
• W2904009992 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6299583" @default.
• W2904009992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30563499" @default.
• W2904009992 hasPublicationYear "2018" @default.
• W2904009992 type Work @default.
• W2904009992 sameAs 2904009992 @default.
• W2904009992 citedByCount "29" @default.
• W2904009992 countsByYear W29040099922019 @default.
• W2904009992 countsByYear W29040099922020 @default.
• W2904009992 countsByYear W29040099922021 @default.
• W2904009992 countsByYear W29040099922022 @default.
• W2904009992 countsByYear W29040099922023 @default.
• W2904009992 crossrefType "journal-article" @default.
• W2904009992 hasAuthorship W2904009992A5003072750 @default.
• W2904009992 hasAuthorship W2904009992A5010280256 @default.
• W2904009992 hasAuthorship W2904009992A5013268190 @default.
• W2904009992 hasAuthorship W2904009992A5014591774 @default.
• W2904009992 hasAuthorship W2904009992A5016292208 @default.
• W2904009992 hasAuthorship W2904009992A5023932305 @default.

• next