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- W2904029418 endingPage "3982" @default.
- W2904029418 startingPage "3982" @default.
- W2904029418 abstract "Hyperimmune globulin (HIG) has shown efficacy against human cytomegalovirus (HCMV) for both transplant and congenital transmission indications. Replicating that activity with a monoclonal antibody (mAb) offers the potential for improved consistency in manufacturing, lower infusion volume, and improved pharmacokinetics, as well as reduced risk of off-target reactivity leading to toxicity. HCMV pathology is linked to its broad cell tropism. The glycoprotein B (gB) envelope protein is important for infections in all cell types. Within gB, the antigenic determinant (AD)-2 Site I is qualitatively more highly-conserved than any other region of the virus. TRL345, a high affinity (Kd = 50 pM) native human mAb to this site, has shown efficacy in neutralizing the infection of fibroblasts, endothelial and epithelial cells, as well as specialized placental cells including trophoblast progenitor cells. It has also been shown to block the infection of placental fragments grown ex vivo, and to reduce syncytial spread in fibroblasts in vitro. Manufacturing and toxicology preparation for filing an IND (investigational new drug) application with the US Food and Drug Administration (FDA) are expected to be completed in mid-2019." @default.
- W2904029418 created "2018-12-22" @default.
- W2904029418 creator A5012991571 @default.
- W2904029418 creator A5015713134 @default.
- W2904029418 creator A5022564926 @default.
- W2904029418 date "2018-12-11" @default.
- W2904029418 modified "2023-09-24" @default.
- W2904029418 title "A Native Human Monoclonal Antibody Targeting HCMV gB (AD-2 Site I)" @default.
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