Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904050503> ?p ?o ?g. }
- W2904050503 endingPage "605" @default.
- W2904050503 startingPage "589" @default.
- W2904050503 abstract "Cell proliferation within a fluid-filled porous tissue-engineering scaffold depends on a sensitive choice of pore geometry and flow rates: regions of high curvature encourage cell proliferation, while a critical flow rate is required to promote growth for certain cell types. When the flow rate is too slow, the nutrient supply is limited; when it is too fast, cells may be damaged by the high fluid shear stress. As a result, determining appropriate tissue-engineering-construct geometries and operating regimes poses a significant challenge that cannot be addressed by experimentation alone. In this paper, we present a mathematical theory for the fluid flow within a pore of a tissue-engineering scaffold, which is coupled to the growth of cells on the pore walls. We exploit the slenderness of a pore that is typical in such a scenario, to derive a reduced model that enables a comprehensive analysis of the system to be performed. We derive analytical solutions in a particular case of a nearly piecewise constant growth law and compare these with numerical solutions of the reduced model. Qualitative comparisons of tissue morphologies predicted by our model, with those observed experimentally, are also made. We demonstrate how the simplified system may be used to make predictions on the design of a tissue-engineering scaffold and the appropriate operating regime that ensures a desired level of tissue growth." @default.
- W2904050503 created "2018-12-22" @default.
- W2904050503 creator A5020574438 @default.
- W2904050503 creator A5029133213 @default.
- W2904050503 creator A5057916411 @default.
- W2904050503 creator A5076651454 @default.
- W2904050503 date "2018-12-12" @default.
- W2904050503 modified "2023-09-23" @default.
- W2904050503 title "Curvature- and fluid-stress-driven tissue growth in a tissue-engineering scaffold pore" @default.
- W2904050503 cites W167881715 @default.
- W2904050503 cites W1784155883 @default.
- W2904050503 cites W1974144665 @default.
- W2904050503 cites W1978852166 @default.
- W2904050503 cites W1985229642 @default.
- W2904050503 cites W2008277897 @default.
- W2904050503 cites W2019856728 @default.
- W2904050503 cites W2020033091 @default.
- W2904050503 cites W2028596690 @default.
- W2904050503 cites W2035095582 @default.
- W2904050503 cites W2044691550 @default.
- W2904050503 cites W2056258594 @default.
- W2904050503 cites W2060250773 @default.
- W2904050503 cites W2061671034 @default.
- W2904050503 cites W2073475578 @default.
- W2904050503 cites W2074165115 @default.
- W2904050503 cites W2086269269 @default.
- W2904050503 cites W2087137783 @default.
- W2904050503 cites W2100811767 @default.
- W2904050503 cites W2113042424 @default.
- W2904050503 cites W2121603365 @default.
- W2904050503 cites W2125170987 @default.
- W2904050503 cites W2139457077 @default.
- W2904050503 cites W2155343604 @default.
- W2904050503 cites W2155833642 @default.
- W2904050503 cites W2165327556 @default.
- W2904050503 cites W2165372239 @default.
- W2904050503 cites W2169700988 @default.
- W2904050503 cites W2243540690 @default.
- W2904050503 cites W2401482619 @default.
- W2904050503 cites W2562843154 @default.
- W2904050503 cites W2605313741 @default.
- W2904050503 cites W2892266802 @default.
- W2904050503 cites W2963911726 @default.
- W2904050503 cites W3101914876 @default.
- W2904050503 cites W4214749573 @default.
- W2904050503 cites W72349741 @default.
- W2904050503 doi "https://doi.org/10.1007/s10237-018-1103-y" @default.
- W2904050503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30542833" @default.
- W2904050503 hasPublicationYear "2018" @default.
- W2904050503 type Work @default.
- W2904050503 sameAs 2904050503 @default.
- W2904050503 citedByCount "14" @default.
- W2904050503 countsByYear W29040505032019 @default.
- W2904050503 countsByYear W29040505032020 @default.
- W2904050503 countsByYear W29040505032021 @default.
- W2904050503 countsByYear W29040505032022 @default.
- W2904050503 countsByYear W29040505032023 @default.
- W2904050503 crossrefType "journal-article" @default.
- W2904050503 hasAuthorship W2904050503A5020574438 @default.
- W2904050503 hasAuthorship W2904050503A5029133213 @default.
- W2904050503 hasAuthorship W2904050503A5057916411 @default.
- W2904050503 hasAuthorship W2904050503A5076651454 @default.
- W2904050503 hasBestOaLocation W29040505031 @default.
- W2904050503 hasConcept C105569014 @default.
- W2904050503 hasConcept C121332964 @default.
- W2904050503 hasConcept C127413603 @default.
- W2904050503 hasConcept C136229726 @default.
- W2904050503 hasConcept C138885662 @default.
- W2904050503 hasConcept C159985019 @default.
- W2904050503 hasConcept C172120300 @default.
- W2904050503 hasConcept C186060115 @default.
- W2904050503 hasConcept C192562407 @default.
- W2904050503 hasConcept C195065555 @default.
- W2904050503 hasConcept C21036866 @default.
- W2904050503 hasConcept C21141959 @default.
- W2904050503 hasConcept C2524010 @default.
- W2904050503 hasConcept C33923547 @default.
- W2904050503 hasConcept C38349280 @default.
- W2904050503 hasConcept C41895202 @default.
- W2904050503 hasConcept C49892992 @default.
- W2904050503 hasConcept C57879066 @default.
- W2904050503 hasConcept C6648577 @default.
- W2904050503 hasConcept C86803240 @default.
- W2904050503 hasConcept C89429830 @default.
- W2904050503 hasConcept C90278072 @default.
- W2904050503 hasConceptScore W2904050503C105569014 @default.
- W2904050503 hasConceptScore W2904050503C121332964 @default.
- W2904050503 hasConceptScore W2904050503C127413603 @default.
- W2904050503 hasConceptScore W2904050503C136229726 @default.
- W2904050503 hasConceptScore W2904050503C138885662 @default.
- W2904050503 hasConceptScore W2904050503C159985019 @default.
- W2904050503 hasConceptScore W2904050503C172120300 @default.
- W2904050503 hasConceptScore W2904050503C186060115 @default.
- W2904050503 hasConceptScore W2904050503C192562407 @default.
- W2904050503 hasConceptScore W2904050503C195065555 @default.
- W2904050503 hasConceptScore W2904050503C21036866 @default.
- W2904050503 hasConceptScore W2904050503C21141959 @default.
- W2904050503 hasConceptScore W2904050503C2524010 @default.