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- W2904081981 abstract "Trypanosoma brucei infection causes human African trypanosomiasis, also known as sleeping sickness, a disease with a nearly 100% fatality rate when untreated. Current drugs are expensive, toxic, and highly impractical to administer, prompting the community to explore various unique aspects of T. brucei biology in search of better treatments. In this study, we identified the protein arginine methyltransferase (PRMT), Tb PRMT1, as a factor that modulates numerous aspects of T. brucei biology. These include glycolysis and life cycle progression signaling, both of which are being intensely researched toward identification of potential drug targets. Our data will aid research in those fields. Furthermore, we demonstrate for the first time a direct association of a PRMT with nucleic acids, a finding we believe could translate to other organisms, including humans, thereby impacting research in fields as distant as human cancer biology and immune response modulation." @default.
- W2904081981 created "2018-12-22" @default.
- W2904081981 creator A5000336321 @default.
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- W2904081981 date "2018-12-21" @default.
- W2904081981 modified "2023-10-17" @default.
- W2904081981 title "Trypanosoma brucei PRMT1 Is a Nucleic Acid Binding Protein with a Role in Energy Metabolism and the Starvation Stress Response" @default.
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- W2904081981 doi "https://doi.org/10.1128/mbio.02430-18" @default.
- W2904081981 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6299225" @default.
- W2904081981 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30563898" @default.
- W2904081981 hasPublicationYear "2018" @default.
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