FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904098315> ?p ?o ?g. }

• W2904098315 abstract "The role of cellular changes in the neurovascular unit is increasingly being investigated to understand the pathogenesis of Alzheimers disease. The aim of the current study was to determine the time course of recognition memory impairment in the J20 mouse model of AD, in relation to neuroinflammatory responses and the pathology of Aβ. Male hAPP-J20 and wild-type mice were assessed at 3, 6, 9, and 12 months of age. The spontaneous object recognition (SOR) task provided a measure of memory, with assessment of both a short delay (1 min) and a long delay (4 hrs). Immunohistochemistry was used to characterise Aβ-deposition, and quantify astrocyte and microglial responses. At all ages tested J20 mice had impaired long-term, but preserved short-term, recognition memory. Wild-types demonstrated preserved long-term memory up to 9 months of age, and preserved short-term memory at all ages tested. Plaque pathology in the J20 mice was present from 6 months onwards, with co-localisation of reactive microglia and activated astrocytes. Reactive microglia and astrocyte activation in the hippocampus were significantly greater in the J20 mice at 9 months, compared to wild-types. This study contributes to our understanding of the pathological and cognitive mechanisms at play in AD. J20 mice showed impairment in retaining information over longer periods from an early age, preceding the deposition of Aβ and glial activation. Defining early physiological changes in relation to cognitive decline could provide insight into new therapeutic targets early in the disease process, when intervention is most likely to effectively slow disease progression." @default.
• W2904098315 created "2018-12-22" @default.
• W2904098315 creator A5013005945 @default.
• W2904098315 creator A5047417137 @default.
• W2904098315 creator A5057685617 @default.
• W2904098315 creator A5066881626 @default.
• W2904098315 creator A5071166311 @default.
• W2904098315 creator A5072105682 @default.
• W2904098315 creator A5091901475 @default.
• W2904098315 date "2018-12-13" @default.
• W2904098315 modified "2023-09-23" @default.
• W2904098315 title "The time course of recognition memory impairment and glial pathology in the hAPP-J20 mouse model of Alzheimer's disease." @default.
• W2904098315 cites W1585782290 @default.
• W2904098315 cites W1981106800 @default.
• W2904098315 cites W1982313782 @default.
• W2904098315 cites W1983166842 @default.
• W2904098315 cites W1988655607 @default.
• W2904098315 cites W1990774375 @default.
• W2904098315 cites W1991457465 @default.
• W2904098315 cites W1992598058 @default.
• W2904098315 cites W1998126371 @default.
• W2904098315 cites W2001618696 @default.
• W2904098315 cites W2003320905 @default.
• W2904098315 cites W2005627616 @default.
• W2904098315 cites W2009270644 @default.
• W2904098315 cites W2012482368 @default.
• W2904098315 cites W2014847319 @default.
• W2904098315 cites W2018524464 @default.
• W2904098315 cites W2020526736 @default.
• W2904098315 cites W2020725667 @default.
• W2904098315 cites W2024032885 @default.
• W2904098315 cites W2027675329 @default.
• W2904098315 cites W2032847834 @default.
• W2904098315 cites W2037154303 @default.
• W2904098315 cites W2038749059 @default.
• W2904098315 cites W2039930606 @default.
• W2904098315 cites W2043826241 @default.
• W2904098315 cites W2045262404 @default.
• W2904098315 cites W2059109913 @default.
• W2904098315 cites W2059215368 @default.
• W2904098315 cites W2064119008 @default.
• W2904098315 cites W2067267561 @default.
• W2904098315 cites W2068354213 @default.
• W2904098315 cites W2071534876 @default.
• W2904098315 cites W2072000472 @default.
• W2904098315 cites W2072441360 @default.
• W2904098315 cites W2074661552 @default.
• W2904098315 cites W2075481535 @default.
• W2904098315 cites W2078047435 @default.
• W2904098315 cites W2078459727 @default.
• W2904098315 cites W2083171256 @default.
• W2904098315 cites W2084629122 @default.
• W2904098315 cites W2090023755 @default.
• W2904098315 cites W2095056606 @default.
• W2904098315 cites W2095456987 @default.
• W2904098315 cites W2103352646 @default.
• W2904098315 cites W2103860224 @default.
• W2904098315 cites W2104932745 @default.
• W2904098315 cites W2112880160 @default.
• W2904098315 cites W2121779273 @default.
• W2904098315 cites W2125547750 @default.
• W2904098315 cites W2128686867 @default.
• W2904098315 cites W2143056578 @default.
• W2904098315 cites W2144529104 @default.
• W2904098315 cites W2144531560 @default.
• W2904098315 cites W2150746478 @default.
• W2904098315 cites W2150845749 @default.
• W2904098315 cites W2151137844 @default.
• W2904098315 cites W2155704304 @default.
• W2904098315 cites W2169017969 @default.
• W2904098315 cites W2169308121 @default.
• W2904098315 cites W2171502370 @default.
• W2904098315 cites W2411253786 @default.
• W2904098315 cites W2497919201 @default.
• W2904098315 cites W2588124790 @default.
• W2904098315 cites W2609808521 @default.
• W2904098315 cites W2610358395 @default.
• W2904098315 cites W2751877438 @default.
• W2904098315 cites W2901822859 @default.
• W2904098315 cites W2246441098 @default.
• W2904098315 doi "https://doi.org/10.1101/495960" @default.
• W2904098315 hasPublicationYear "2018" @default.
• W2904098315 type Work @default.
• W2904098315 sameAs 2904098315 @default.
• W2904098315 citedByCount "0" @default.
• W2904098315 crossrefType "posted-content" @default.
• W2904098315 hasAuthorship W2904098315A5013005945 @default.
• W2904098315 hasAuthorship W2904098315A5047417137 @default.
• W2904098315 hasAuthorship W2904098315A5057685617 @default.
• W2904098315 hasAuthorship W2904098315A5066881626 @default.
• W2904098315 hasAuthorship W2904098315A5071166311 @default.
• W2904098315 hasAuthorship W2904098315A5072105682 @default.
• W2904098315 hasAuthorship W2904098315A5091901475 @default.
• W2904098315 hasBestOaLocation W29040983151 @default.
• W2904098315 hasConcept C142724271 @default.
• W2904098315 hasConcept C15744967 @default.
• W2904098315 hasConcept C169760540 @default.
• W2904098315 hasConcept C169900460 @default.
• W2904098315 hasConcept C203014093 @default.
• W2904098315 hasConcept C207886595 @default.

• next