Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904104590> ?p ?o ?g. }
- W2904104590 endingPage "4375" @default.
- W2904104590 startingPage "4365" @default.
- W2904104590 abstract "Osteoclasts derived from hematopoietic cells are activated on bone surface. To resorb bone, osteoclasts release acid and lysosome acid hydrolase via membrane transport. Prostate transmembrane protein androgen induced 1 (Pmepa1) is a type I transmembrane protein that regulates proliferation, migration, and metastasis of cancer cells. Because recent reports showed that Pmepa1 is involved in membrane transport in cancer cells, we investigated the role of Pmepa1 in osteoclast function. Pmepa1 expression was barely detected in osteoclasts formed on plastic surfaces in vitro, but was markedly increased in activated osteoclasts formed on calcified matrix. Inhibitors of bone resorption, such as alendronate, bafilomycin A1, and the PI3K inhibitor LY294002, suppressed the expression of Pmepa1 in osteoclasts. Knockdown of Pmepa1 expression impaired bone resorption activity and inhibited formation of a ring-like, actin-rich podosome belt that is essential for osteoclast function. Pmepa1 protein localized to lysosomes in osteoclasts. In addition, in sites of bone destruction observed in rats with adjuvant-induced arthritis, a marked high level of Pmepa1 expression was associated with the osteoclasts' resorbing bone. Our results suggest that Pmepa1 is a critical regulator of bone resorption and is a promising marker for activated osteoclasts and a potential therapeutic target in pathologic bone destruction.—Xu, X., Hirata, H., Shiraki, M., Kamohara, A., Nishioka, K., Miyamoto, H., Kukita, T., Kukita, A. Prostate transmembrane protein androgen induced 1 is induced by activation of osteoclasts and regulates bone resorption. FASEB J. 33, 4365–4375 (2019). www.fasebj.org" @default.
- W2904104590 created "2018-12-22" @default.
- W2904104590 creator A5005311244 @default.
- W2904104590 creator A5020141885 @default.
- W2904104590 creator A5020411781 @default.
- W2904104590 creator A5049629119 @default.
- W2904104590 creator A5050106835 @default.
- W2904104590 creator A5084214056 @default.
- W2904104590 creator A5090769439 @default.
- W2904104590 creator A5090795865 @default.
- W2904104590 date "2018-12-17" @default.
- W2904104590 modified "2023-10-02" @default.
- W2904104590 title "Prostate transmembrane protein androgen induced 1 is induced by activation of osteoclasts and regulates bone resorption" @default.
- W2904104590 cites W152275866 @default.
- W2904104590 cites W1899740218 @default.
- W2904104590 cites W1951828453 @default.
- W2904104590 cites W1963938589 @default.
- W2904104590 cites W1970630991 @default.
- W2904104590 cites W1979914709 @default.
- W2904104590 cites W1985478291 @default.
- W2904104590 cites W1985812687 @default.
- W2904104590 cites W1991275660 @default.
- W2904104590 cites W1991498973 @default.
- W2904104590 cites W1992166679 @default.
- W2904104590 cites W1994824666 @default.
- W2904104590 cites W1998735841 @default.
- W2904104590 cites W2000855716 @default.
- W2904104590 cites W2002318706 @default.
- W2904104590 cites W2006764264 @default.
- W2904104590 cites W2009570140 @default.
- W2904104590 cites W2019490564 @default.
- W2904104590 cites W2021794410 @default.
- W2904104590 cites W2024675913 @default.
- W2904104590 cites W2033136132 @default.
- W2904104590 cites W2042090138 @default.
- W2904104590 cites W2049768643 @default.
- W2904104590 cites W2056371948 @default.
- W2904104590 cites W2057907407 @default.
- W2904104590 cites W2059050560 @default.
- W2904104590 cites W2067251059 @default.
- W2904104590 cites W2082368315 @default.
- W2904104590 cites W2084897482 @default.
- W2904104590 cites W2093252878 @default.
- W2904104590 cites W2113035264 @default.
- W2904104590 cites W2114935509 @default.
- W2904104590 cites W2116389818 @default.
- W2904104590 cites W2122854426 @default.
- W2904104590 cites W2134304734 @default.
- W2904104590 cites W2153628853 @default.
- W2904104590 cites W2160830589 @default.
- W2904104590 cites W2169383425 @default.
- W2904104590 cites W2314794990 @default.
- W2904104590 cites W2346208830 @default.
- W2904104590 cites W2402175739 @default.
- W2904104590 cites W2535778183 @default.
- W2904104590 cites W2573620244 @default.
- W2904104590 cites W2601358662 @default.
- W2904104590 cites W2742561468 @default.
- W2904104590 cites W2768286346 @default.
- W2904104590 cites W280215210 @default.
- W2904104590 cites W953407439 @default.
- W2904104590 doi "https://doi.org/10.1096/fj.201801573r" @default.
- W2904104590 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30557043" @default.
- W2904104590 hasPublicationYear "2018" @default.
- W2904104590 type Work @default.
- W2904104590 sameAs 2904104590 @default.
- W2904104590 citedByCount "12" @default.
- W2904104590 countsByYear W29041045902020 @default.
- W2904104590 countsByYear W29041045902021 @default.
- W2904104590 countsByYear W29041045902022 @default.
- W2904104590 countsByYear W29041045902023 @default.
- W2904104590 crossrefType "journal-article" @default.
- W2904104590 hasAuthorship W2904104590A5005311244 @default.
- W2904104590 hasAuthorship W2904104590A5020141885 @default.
- W2904104590 hasAuthorship W2904104590A5020411781 @default.
- W2904104590 hasAuthorship W2904104590A5049629119 @default.
- W2904104590 hasAuthorship W2904104590A5050106835 @default.
- W2904104590 hasAuthorship W2904104590A5084214056 @default.
- W2904104590 hasAuthorship W2904104590A5090769439 @default.
- W2904104590 hasAuthorship W2904104590A5090795865 @default.
- W2904104590 hasBestOaLocation W29041045901 @default.
- W2904104590 hasConcept C134018914 @default.
- W2904104590 hasConcept C170493617 @default.
- W2904104590 hasConcept C185592680 @default.
- W2904104590 hasConcept C202751555 @default.
- W2904104590 hasConcept C24530287 @default.
- W2904104590 hasConcept C2776033226 @default.
- W2904104590 hasConcept C502942594 @default.
- W2904104590 hasConcept C55493867 @default.
- W2904104590 hasConcept C673006 @default.
- W2904104590 hasConcept C86803240 @default.
- W2904104590 hasConcept C95444343 @default.
- W2904104590 hasConceptScore W2904104590C134018914 @default.
- W2904104590 hasConceptScore W2904104590C170493617 @default.
- W2904104590 hasConceptScore W2904104590C185592680 @default.
- W2904104590 hasConceptScore W2904104590C202751555 @default.
- W2904104590 hasConceptScore W2904104590C24530287 @default.
- W2904104590 hasConceptScore W2904104590C2776033226 @default.