FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904109650> ?p ?o ?g. }

• W2904109650 endingPage "e1006612" @default.
• W2904109650 startingPage "e1006612" @default.
• W2904109650 abstract "Neural morphology and membrane properties vary greatly between cell types in the nervous system. The computations and local circuit connectivity that neurons support are thought to be the key factors constraining the cells’ biophysical properties. Nevertheless, additional constraints can be expected to further shape neuronal design. Here, we focus on a particularly energy-intense system (as indicated by metabolic markers): principal neurons in the medial superior olive (MSO) nucleus of the auditory brainstem. Based on a modeling approach, we show that a trade-off between the level of performance of a functionally relevant computation and energy consumption predicts optimal ranges for cell morphology and membrane properties. The biophysical parameters appear most strongly constrained by functional needs, while energy use is minimized as long as function can be maintained. The key factors that determine model performance and energy consumption are 1) the saturation of the synaptic conductance input and 2) the temporal resolution of the postsynaptic signals as they reach the soma, which is largely determined by active membrane properties. MSO cells seem to operate close to pareto optimality, i.e., the trade-off boundary between performance and energy consumption that is formed by the set of optimal models. Good performance for drastically lower costs could in theory be achieved by small neurons without dendrites, as seen in the avian auditory system, pointing to additional constraints for mammalian MSO cells, including their circuit connectivity." @default.
• W2904109650 created "2018-12-22" @default.
• W2904109650 creator A5061116254 @default.
• W2904109650 creator A5067638731 @default.
• W2904109650 creator A5077991501 @default.
• W2904109650 date "2018-12-06" @default.
• W2904109650 modified "2023-09-27" @default.
• W2904109650 title "Function and energy consumption constrain neuronal biophysics in a canonical computation: Coincidence detection" @default.
• W2904109650 cites W1577757039 @default.
• W2904109650 cites W1640439680 @default.
• W2904109650 cites W1918121117 @default.
• W2904109650 cites W1956327946 @default.
• W2904109650 cites W1957242737 @default.
• W2904109650 cites W1965210407 @default.
• W2904109650 cites W1967437460 @default.
• W2904109650 cites W1973747802 @default.
• W2904109650 cites W1978193313 @default.
• W2904109650 cites W1983443700 @default.
• W2904109650 cites W1983446016 @default.
• W2904109650 cites W1995054780 @default.
• W2904109650 cites W1999488699 @default.
• W2904109650 cites W2000984083 @default.
• W2904109650 cites W2017580849 @default.
• W2904109650 cites W2021141393 @default.
• W2904109650 cites W2025198626 @default.
• W2904109650 cites W2027593067 @default.
• W2904109650 cites W2028288161 @default.
• W2904109650 cites W2033001588 @default.
• W2904109650 cites W2033071630 @default.
• W2904109650 cites W2037156065 @default.
• W2904109650 cites W2041158750 @default.
• W2904109650 cites W2042422091 @default.
• W2904109650 cites W2049058862 @default.
• W2904109650 cites W2054388777 @default.
• W2904109650 cites W2055367555 @default.
• W2904109650 cites W2060166393 @default.
• W2904109650 cites W2061953874 @default.
• W2904109650 cites W2062029765 @default.
• W2904109650 cites W2075759996 @default.
• W2904109650 cites W2082472298 @default.
• W2904109650 cites W2084598301 @default.
• W2904109650 cites W2090675241 @default.
• W2904109650 cites W2091252001 @default.
• W2904109650 cites W2095870370 @default.
• W2904109650 cites W2109447493 @default.
• W2904109650 cites W2117120818 @default.
• W2904109650 cites W2120297697 @default.
• W2904109650 cites W2121464008 @default.
• W2904109650 cites W2128175152 @default.
• W2904109650 cites W2130453501 @default.
• W2904109650 cites W2135668456 @default.
• W2904109650 cites W2139959380 @default.
• W2904109650 cites W2150675586 @default.
• W2904109650 cites W2152435897 @default.
• W2904109650 cites W2158947594 @default.
• W2904109650 cites W2162078358 @default.
• W2904109650 cites W2164189343 @default.
• W2904109650 cites W2192126750 @default.
• W2904109650 cites W2255839289 @default.
• W2904109650 cites W2493097620 @default.
• W2904109650 cites W2521862911 @default.
• W2904109650 cites W2562989337 @default.
• W2904109650 cites W2571918371 @default.
• W2904109650 cites W4212952892 @default.
• W2904109650 cites W4233766477 @default.
• W2904109650 doi "https://doi.org/10.1371/journal.pcbi.1006612" @default.
• W2904109650 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6312336" @default.
• W2904109650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30521528" @default.
• W2904109650 hasPublicationYear "2018" @default.
• W2904109650 type Work @default.
• W2904109650 sameAs 2904109650 @default.
• W2904109650 citedByCount "15" @default.
• W2904109650 countsByYear W29041096502019 @default.
• W2904109650 countsByYear W29041096502020 @default.
• W2904109650 countsByYear W29041096502021 @default.
• W2904109650 countsByYear W29041096502022 @default.
• W2904109650 countsByYear W29041096502023 @default.
• W2904109650 crossrefType "journal-article" @default.
• W2904109650 hasAuthorship W2904109650A5061116254 @default.
• W2904109650 hasAuthorship W2904109650A5067638731 @default.
• W2904109650 hasAuthorship W2904109650A5077991501 @default.
• W2904109650 hasBestOaLocation W29041096501 @default.
• W2904109650 hasConcept C11413529 @default.
• W2904109650 hasConcept C121332964 @default.
• W2904109650 hasConcept C142724271 @default.
• W2904109650 hasConcept C154945302 @default.
• W2904109650 hasConcept C169760540 @default.
• W2904109650 hasConcept C170493617 @default.
• W2904109650 hasConcept C181911157 @default.
• W2904109650 hasConcept C186060115 @default.
• W2904109650 hasConcept C18903297 @default.
• W2904109650 hasConcept C197341189 @default.
• W2904109650 hasConcept C204787440 @default.
• W2904109650 hasConcept C207579572 @default.
• W2904109650 hasConcept C2778794669 @default.
• W2904109650 hasConcept C2779617337 @default.
• W2904109650 hasConcept C2779832538 @default.
• W2904109650 hasConcept C2780165032 @default.

• next