Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904114042> ?p ?o ?g. }
- W2904114042 endingPage "91" @default.
- W2904114042 startingPage "80" @default.
- W2904114042 abstract "The DNA-PK complex is the major component of the predominant mechanism of DSB repair in humans. In addition, this complex is involved in many other processes such as DNA recombination, genome maintenance, apoptosis and transcription regulation. Several studies have linked the decrease of the DNA-PK activity with cancer initiation, due to defects in the repair. On another hand, higher DNA-PK expression and activity have been observed in various other tumor cells and have been linked with a decrease of the efficiency of anti-tumor drugs. It has also been shown that DNA-PK is critical for the integration of the HIV-1 DNA into the cell host genome and promotes replication and transcription of the virus. Targeting this complex makes therefore sense to treat these two pathologies. However, according to the status of HIV-1 replication (active versus latent replication) or to the tumor grade cells (initiation versus metastasis), the way to target this DNA-PK complex might be rather different. In this review, we discuss the importance of DNA-PK complex in two major pathologies i.e. HIV-1 infection and cancer, and the rationale use of therapies aiming to target this complex." @default.
- W2904114042 created "2018-12-22" @default.
- W2904114042 creator A5012915002 @default.
- W2904114042 creator A5083249607 @default.
- W2904114042 creator A5085503172 @default.
- W2904114042 date "2019-02-01" @default.
- W2904114042 modified "2023-10-03" @default.
- W2904114042 title "Targeting the DNA-PK complex: Its rationale use in cancer and HIV-1 infection" @default.
- W2904114042 cites W1515564094 @default.
- W2904114042 cites W1648266957 @default.
- W2904114042 cites W1841331176 @default.
- W2904114042 cites W1855851918 @default.
- W2904114042 cites W1958134851 @default.
- W2904114042 cites W1968851685 @default.
- W2904114042 cites W1973268287 @default.
- W2904114042 cites W1978787132 @default.
- W2904114042 cites W1986830781 @default.
- W2904114042 cites W1987526188 @default.
- W2904114042 cites W1994327955 @default.
- W2904114042 cites W1994482376 @default.
- W2904114042 cites W1999206490 @default.
- W2904114042 cites W1999659306 @default.
- W2904114042 cites W2001839708 @default.
- W2904114042 cites W2002231685 @default.
- W2904114042 cites W2003581594 @default.
- W2904114042 cites W2007369689 @default.
- W2904114042 cites W2008089042 @default.
- W2904114042 cites W2020825769 @default.
- W2904114042 cites W2022643490 @default.
- W2904114042 cites W2027630134 @default.
- W2904114042 cites W2040847982 @default.
- W2904114042 cites W2041751293 @default.
- W2904114042 cites W2044151182 @default.
- W2904114042 cites W2045201384 @default.
- W2904114042 cites W2048342686 @default.
- W2904114042 cites W2053662154 @default.
- W2904114042 cites W2057214112 @default.
- W2904114042 cites W2059229106 @default.
- W2904114042 cites W2059684890 @default.
- W2904114042 cites W2059875201 @default.
- W2904114042 cites W2059971436 @default.
- W2904114042 cites W2064102777 @default.
- W2904114042 cites W2067117419 @default.
- W2904114042 cites W2070524106 @default.
- W2904114042 cites W2076879573 @default.
- W2904114042 cites W2083431317 @default.
- W2904114042 cites W2083960841 @default.
- W2904114042 cites W2086333179 @default.
- W2904114042 cites W2092638438 @default.
- W2904114042 cites W2096782300 @default.
- W2904114042 cites W2100213817 @default.
- W2904114042 cites W2100980793 @default.
- W2904114042 cites W2107632586 @default.
- W2904114042 cites W2107866413 @default.
- W2904114042 cites W2109997480 @default.
- W2904114042 cites W2110488501 @default.
- W2904114042 cites W2114860131 @default.
- W2904114042 cites W2120932387 @default.
- W2904114042 cites W2126722577 @default.
- W2904114042 cites W2127467277 @default.
- W2904114042 cites W2129697500 @default.
- W2904114042 cites W2131077173 @default.
- W2904114042 cites W2132368077 @default.
- W2904114042 cites W2134259738 @default.
- W2904114042 cites W2135640980 @default.
- W2904114042 cites W2137239016 @default.
- W2904114042 cites W2137557230 @default.
- W2904114042 cites W2137755195 @default.
- W2904114042 cites W2145200068 @default.
- W2904114042 cites W2160239844 @default.
- W2904114042 cites W2162412306 @default.
- W2904114042 cites W2162704849 @default.
- W2904114042 cites W2169509924 @default.
- W2904114042 cites W2173456459 @default.
- W2904114042 cites W2188803041 @default.
- W2904114042 cites W2234306214 @default.
- W2904114042 cites W2271762346 @default.
- W2904114042 cites W229738109 @default.
- W2904114042 cites W2315225663 @default.
- W2904114042 cites W2345031133 @default.
- W2904114042 cites W2346159484 @default.
- W2904114042 cites W2354646343 @default.
- W2904114042 cites W2396421546 @default.
- W2904114042 cites W2398240122 @default.
- W2904114042 cites W2413089086 @default.
- W2904114042 cites W2461398495 @default.
- W2904114042 cites W2563432654 @default.
- W2904114042 cites W2602832336 @default.
- W2904114042 cites W2603139324 @default.
- W2904114042 cites W2604974880 @default.
- W2904114042 cites W2704159227 @default.
- W2904114042 cites W2730689217 @default.
- W2904114042 cites W2731860142 @default.
- W2904114042 cites W2734206710 @default.
- W2904114042 cites W2734950144 @default.
- W2904114042 cites W2736199480 @default.
- W2904114042 cites W2745424508 @default.
- W2904114042 cites W2754804497 @default.