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- W2904118728 abstract "Toxin-antitoxin (TA) loci encode two-component genetic elements: a stable protein and an unstable (a protein or a regulatory RNA) that neutralizes the toxin action. A lot of researches have been done on the cellular targets of toxins, the molecular structures and biological functions, and the mechanisms of antitoxin actions. The studies not only discovered a multitude of physiology roles of TA systems, but also led to a number of applications for various purposes. Currently, five TA systems have been discovered in countless bacteria and archaea. The antitoxins in type I systems are regulatory RNAs which can employ several different modes to counteract toxin proteins and their special RNA regulatory strategies have made type I TA systems become a focus of TA researches. Within this review, we will summarize our current knowledge on type I TA system and look into the future of their potential applications." @default.
- W2904118728 created "2018-12-22" @default.
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- W2904118728 date "2016-10-01" @default.
- W2904118728 modified "2023-09-27" @default.
- W2904118728 title "The Progress of Researches on Bacterial Type I Toxin-Antitoxin Systems" @default.
- W2904118728 doi "https://doi.org/10.16476/j.pibb.2016.0217" @default.
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