FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904122034> ?p ?o ?g. }

• W2904122034 endingPage "194" @default.
• W2904122034 startingPage "185" @default.
• W2904122034 abstract "In vivo biodistribution analyses, especially in tumors, of nucleic acids delivered with nanoparticles are important to develop drug delivery technologies for medical use. We previously developed wrapsome® (WS), an ~100 nm liposomal nanoparticle that can encapsulate siRNA, and reported that WS accumulates in tumors in vivo and inhibits their growth by an enhanced permeability and retention effect. In the present study, we evaluated the pharmacokinetics of nucleic acid-containing nanoparticles by combining dynamic positron emission tomography (PET) imaging and liquid chromatography-tandem mass spectrometry (LC/MS/MS) analysis. An 18-mer phosphorothioate oligodeoxynucleotide (ODN), trabedersen, was used as a model drug and was encapsulated in WS. Dynamic PET imaging and time-activity curve analysis of WS-encapsulated 64Cu-labeled ODNs administered to mice with MIA PaCa-2 subcutaneous xenograft tumors showed tumor accumulation (~3% injected dose per gram (%ID/g)) and liver accumulation (~30 %ID/g) at 24 h. Under these conditions, LC/MS/MS analysis showed that the level of intact ODNs was 1.62 %ID/g in the tumor and 1.70 %ID/g in the liver. From these pharmacokinetic data, the intact/accumulated ODN ratios were calculated using the following equation: intact/accumulated ODN ratio (%) = %ID/g LC/MS/MS, tissue, mean/%ID/g PET, tissue, mean × 100. Interestingly, the ratios for the tumor and kidney were maintained at 20–50% over 48 h after administration of the WS-encapsulated form. In contrast, the ratio for the liver rapidly decreased at 24 h, showing the same pattern as that for naked ODN. These different patterns indicate that WS effectively protected the ODN in the tumor and kidney, but protected it less efficiently in the liver. A combined approach of dynamic PET imaging and LC/MS/MS analysis will assist the development of nanoparticle-encapsulated nucleic acid drugs, such as those using WSs, to determine their detailed pharmacokinetics." @default.
• W2904122034 created "2018-12-22" @default.
• W2904122034 creator A5012303066 @default.
• W2904122034 creator A5013417193 @default.
• W2904122034 creator A5022193039 @default.
• W2904122034 creator A5023023018 @default.
• W2904122034 creator A5037300111 @default.
• W2904122034 creator A5046795006 @default.
• W2904122034 creator A5047401647 @default.
• W2904122034 creator A5051142944 @default.
• W2904122034 creator A5060263104 @default.
• W2904122034 creator A5062984141 @default.
• W2904122034 creator A5066663160 @default.
• W2904122034 creator A5086192199 @default.
• W2904122034 creator A5087594532 @default.
• W2904122034 date "2019-01-01" @default.
• W2904122034 modified "2023-10-17" @default.
• W2904122034 title "Pharmacokinetic evaluation of liposomal nanoparticle-encapsulated nucleic acid drug: A combined study of dynamic PET imaging and LC/MS/MS analysis" @default.
• W2904122034 cites W1843302206 @default.
• W2904122034 cites W1978863320 @default.
• W2904122034 cites W1981942027 @default.
• W2904122034 cites W1987160944 @default.
• W2904122034 cites W1989072328 @default.
• W2904122034 cites W1989742813 @default.
• W2904122034 cites W1994869675 @default.
• W2904122034 cites W2002516695 @default.
• W2904122034 cites W2011243140 @default.
• W2904122034 cites W2023027859 @default.
• W2904122034 cites W2031483194 @default.
• W2904122034 cites W2032925032 @default.
• W2904122034 cites W2034045987 @default.
• W2904122034 cites W2037141750 @default.
• W2904122034 cites W2039447492 @default.
• W2904122034 cites W2045796779 @default.
• W2904122034 cites W2046763396 @default.
• W2904122034 cites W2051309616 @default.
• W2904122034 cites W2053202538 @default.
• W2904122034 cites W2058906317 @default.
• W2904122034 cites W2060606238 @default.
• W2904122034 cites W2061264526 @default.
• W2904122034 cites W2064173035 @default.
• W2904122034 cites W2068858471 @default.
• W2904122034 cites W2071636590 @default.
• W2904122034 cites W2072587957 @default.
• W2904122034 cites W2082950195 @default.
• W2904122034 cites W2085217622 @default.
• W2904122034 cites W2089157600 @default.
• W2904122034 cites W2092975717 @default.
• W2904122034 cites W2105230577 @default.
• W2904122034 cites W2110863002 @default.
• W2904122034 cites W2132717713 @default.
• W2904122034 cites W2136292351 @default.
• W2904122034 cites W2149562896 @default.
• W2904122034 cites W2155467782 @default.
• W2904122034 cites W2162692691 @default.
• W2904122034 cites W2166796054 @default.
• W2904122034 cites W2167470235 @default.
• W2904122034 cites W2169678660 @default.
• W2904122034 cites W2253403518 @default.
• W2904122034 cites W2366411924 @default.
• W2904122034 cites W2597588035 @default.
• W2904122034 cites W2735302924 @default.
• W2904122034 cites W2742532304 @default.
• W2904122034 cites W2756425540 @default.
• W2904122034 cites W2767839525 @default.
• W2904122034 doi "https://doi.org/10.1016/j.jconrel.2018.12.006" @default.
• W2904122034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30529725" @default.
• W2904122034 hasPublicationYear "2019" @default.
• W2904122034 type Work @default.
• W2904122034 sameAs 2904122034 @default.
• W2904122034 citedByCount "20" @default.
• W2904122034 countsByYear W29041220342019 @default.
• W2904122034 countsByYear W29041220342020 @default.
• W2904122034 countsByYear W29041220342021 @default.
• W2904122034 countsByYear W29041220342022 @default.
• W2904122034 countsByYear W29041220342023 @default.
• W2904122034 crossrefType "journal-article" @default.
• W2904122034 hasAuthorship W2904122034A5012303066 @default.
• W2904122034 hasAuthorship W2904122034A5013417193 @default.
• W2904122034 hasAuthorship W2904122034A5022193039 @default.
• W2904122034 hasAuthorship W2904122034A5023023018 @default.
• W2904122034 hasAuthorship W2904122034A5037300111 @default.
• W2904122034 hasAuthorship W2904122034A5046795006 @default.
• W2904122034 hasAuthorship W2904122034A5047401647 @default.
• W2904122034 hasAuthorship W2904122034A5051142944 @default.
• W2904122034 hasAuthorship W2904122034A5060263104 @default.
• W2904122034 hasAuthorship W2904122034A5062984141 @default.
• W2904122034 hasAuthorship W2904122034A5066663160 @default.
• W2904122034 hasAuthorship W2904122034A5086192199 @default.
• W2904122034 hasAuthorship W2904122034A5087594532 @default.
• W2904122034 hasConcept C112705442 @default.
• W2904122034 hasConcept C150903083 @default.
• W2904122034 hasConcept C178790620 @default.
• W2904122034 hasConcept C185154212 @default.
• W2904122034 hasConcept C185592680 @default.
• W2904122034 hasConcept C202751555 @default.
• W2904122034 hasConcept C207001950 @default.
• W2904122034 hasConcept C24107716 @default.

• next