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- W2904122249 abstract "Purpose Mitomycin C (MMC) plus standard 5-fluorouracil (FU) infusion in weeks 1 and 5 often contributes to radiotherapy interruptions and possibly less-than-ideal outcomes in anal cancer. This study was to evaluate alternative strategies for chemotherapy delivery that might be less toxic or more efficacious, and outcomes of patient-initiated treatment interruption for severe acute toxicity. Materials and methods This was a prospective, nonrandomized study for patients with T1-4N0-3M0 anal squamous carcinoma. Radiotherapy of 54 Gy in 30 fractions over 6 weeks was given with infusion FU 300 mg/m2/day for 96 hours/week for 6 weeks plus bolus MMC at 10 mg/m2 on D1. Results Fifty patients were recruited (72% female). Median age was 60.5 years (35–84). Forty-seven patients (94%) received 54 Gy. Median duration of chemoradiation was 39 days (37–105). Grade 3 and 4 acute toxicity were observed in 66%. Thirty-one percent with severe acute toxicity developed severe late toxicity. Of those who experienced severe late skin toxicity, 29% did not have severe acute toxicity. Disease-free survival at 5 years was 74% (95% confidence interval [CI], 60–84), and at 9 years 61% (95% CI, 46–74). Overall survival at 5 years was 84% (95% CI, 71–92), and at 9 years 67% (95% CI, 50–81). Colostomy-free survival at 5 years was 70% (95% CI, 56–81), and at 9 years 57% (95% CI, 40–72). Conclusion It is feasible to deliver chemoradiation with bolus MMC and protracted infusion FU for anal cancer. Efficacy and toxicity of this regimen seem similar to conventional chemoradiation with FU/MMC. Acute skin toxicity is not a reliable predictor of severe late skin toxicity." @default.
- W2904122249 created "2018-12-22" @default.
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- W2904122249 date "2018-12-09" @default.
- W2904122249 modified "2023-09-28" @default.
- W2904122249 title "A clinical trial with protracted infusion 5‐fluorouracil and mitomycin C for localized squamous cell carcinoma of the anus" @default.
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- W2904122249 doi "https://doi.org/10.1111/ajco.13106" @default.
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