Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904128308> ?p ?o ?g. }
- W2904128308 abstract "Bovine herpesvirus 1 (BoHV-1) is the most frequently diagnosed cause of abortions in pregnant cows and can cause “abortion storms” in susceptible herds. Virulent field strains and even commercially available modified live vaccines can induce abortion, in part because BoHV-1 replicates efficiently in the ovary and corpus luteum. We now demonstrate that progesterone and the progesterone receptor (PR) stimulate productive infection. The BoHV-1 genome contains approximately 100 glucocorticoid receptor (GR) response elements (GREs). Interestingly, the PR can bind and activate many promoters that contain GREs. The PR and Krüppel-like transcription factor 15 (KLF15), which regulate key steps during embryo implantation, cooperate to stimulate productive infection and two viral promoters that drive expression of key viral transcriptional regulators. These studies suggest that the ability of progesterone and the PR to stimulate productive infection has the potential to promote virus spread in reproductive tissue and induce reproductive failure." @default.
- W2904128308 created "2018-12-22" @default.
- W2904128308 creator A5020518181 @default.
- W2904128308 creator A5043320062 @default.
- W2904128308 creator A5047568664 @default.
- W2904128308 creator A5060206598 @default.
- W2904128308 date "2019-01-01" @default.
- W2904128308 modified "2023-10-14" @default.
- W2904128308 title "Synergistic Activation of Bovine Herpesvirus 1 Productive Infection and Viral Regulatory Promoters by the Progesterone Receptor and Krüppel-Like Transcription Factor 15" @default.
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- W2904128308 doi "https://doi.org/10.1128/jvi.01519-18" @default.
- W2904128308 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6288325" @default.
- W2904128308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30305353" @default.
- W2904128308 hasPublicationYear "2019" @default.
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