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• W2904131402 abstract "Introduction: Intravenous administration of lipopolysaccharide (LPS) from Escherichia coli is an experimental model of systemic inflammation that has been widely used for investigating new therapeutic strategies for sepsis, which is characterized by clinical manifestations such as hypo or hyperthermia, tachycardia, hypotension and tachypnea. However, there is a number of doses of LPS used in several studies, and the hemodynamic responses were not well characterized. Thus, the aim of the present study was to evaluate the hemodynamic (arterial pressure and heart rate) responses from unanesthetized rats to different doses of LPS over time. Methods and Results: Femoral artery and vein catheters were inserted into anaesthetized Wistar Hannover male rats for arterial pressure recording and LPS administration, respectively. On the next day, the arterial pressure was recorded before (baseline) and after (90, 180 and 360 min) LPS injection in the unanesthetized subjects. Four different doses of LPS were tested: 0.06 mg/kg (n = 8), 20 mg/kg (n = 4), 30 mg/kg (n = 4), and 40 mg/kg (n = 5). As compared to baseline, the dose of 0.06 mg/kg of LPS decreased the mean arterial pressure at 360 min after its administration (113 ± 4 vs. 103 ± 7 mmHg, p = 0.007). However, the doses of 20, 30 and 40 mg/kg increased the mean arterial pressure at 360 min after LPS, compared to baseline values ( 20 mg/kg: 101 ± 2 vs. 121 ± 4 mmHg, p < 0.001; 30 mg/kg: 115 ± 6 vs. 130 ± 0.4 mmHg, p = 0.023; 40 mg/kg: 92 ± 2 vs. 107 ± 3 mmHg, p = 0.005). In addition, all doses tested increased the heart rate at 360 min after LPS administration ( 0.06 mg/kg: 342 ± 19 vs. 435 ± 11 bpm, p < 0.001; 20 mg/kg: 388 ± 6 vs. 588 ± 24 bpm, p < 0.001; 30 mg/kg: 366 ± 15 vs. 569 ± 8 bpm p < 0.001; 40 mg/kg: 426 ± 27 vs. 606 ± 24 bpm, p < 0.001). Nevertheless, the dose of 0.06 mg/kg promoted a smaller tachycardia as compared to the other doses evaluated ( 0.06 mg/kg: 435 ± 11 bpm; 20 mg/kg: 588 ± 24 bpm; 30 mg/kg: 569 ± 8 bpm; 40 mg/kg: 606 ± 24 bpm, p < 0.001). Conclusions: These findings indicate that it is important to choose the correct dose of LPS, depending on the aim of the study. The current data indicate that each dose of LPS may promote different hemodynamic (mean arterial pressure and heart rate) responses, affecting the therapeutic strategy, for instance, for sepsis." @default.
• W2904131402 created "2018-12-22" @default.
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• W2904131402 date "2018-09-01" @default.
• W2904131402 modified "2023-10-18" @default.
• W2904131402 title "Abstract P287: Time Course of Hemodynamic Responses to Different Doses of Lipopolysaccharide Administration in Unanesthetized Rats" @default.
• W2904131402 doi "https://doi.org/10.1161/hyp.72.suppl_1.p287" @default.
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