Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904131963> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2904131963 endingPage "262" @default.
- W2904131963 startingPage "246" @default.
- W2904131963 abstract "This study investigated the impact of hydroxypropyl methylcellulose (HPMC) viscosity grade, HPMC proportion and particle size fraction on the physical properties of the freeze-dried mannitol-HPMC excipients produced, using multivariate analysis methods. Solutions containing 20%, w/w mannitol-HPMC were freeze-dried and milled to obtain excipients of size fractions 125–355 μm and 355–710 μm to understand the impact of the formulation variables on the molecular, particle and bulk properties of the excipients. Results showed that the freeze-dried mannitol-HPMC excipients were mainly differentiated by 3 overarching properties, in the order of their contribution to the variation in the principal component analysis (PCA) model: (i) freeze-dried cake strength and bulk fill-related properties, (ii) compression behaviour-related properties, and (iii) flow-related properties. These properties were influenced by the HPMC viscosity grade, HPMC proportion and size fraction of excipient used. Freeze-dried excipients containing vLV or lower HPMC proportions had higher bulk densities, thus displaying better packing within the die. For larger excipients, densification by plastic deformation was likely preceded by fragmentation, thus accounting for the higher yield pressure values. The establishment of inter-variable relationships between the physical properties would be useful in further studies on the functional properties of tablets containing these co-freeze-dried mannitol-HPMC tableting excipients." @default.
- W2904131963 created "2018-12-22" @default.
- W2904131963 creator A5020922729 @default.
- W2904131963 creator A5029198152 @default.
- W2904131963 creator A5042875585 @default.
- W2904131963 creator A5050568819 @default.
- W2904131963 date "2019-02-01" @default.
- W2904131963 modified "2023-10-16" @default.
- W2904131963 title "Probing the impact of HPMC viscosity grade and proportion on the physical properties of co-freeze-dried mannitol-HPMC tableting excipients using multivariate analysis methods" @default.
- W2904131963 cites W1593764616 @default.
- W2904131963 cites W1964771923 @default.
- W2904131963 cites W1972265150 @default.
- W2904131963 cites W1976354109 @default.
- W2904131963 cites W1992614745 @default.
- W2904131963 cites W1994923072 @default.
- W2904131963 cites W2002298352 @default.
- W2904131963 cites W2007738220 @default.
- W2904131963 cites W2009788522 @default.
- W2904131963 cites W2017190947 @default.
- W2904131963 cites W2017341540 @default.
- W2904131963 cites W2028895013 @default.
- W2904131963 cites W2029254437 @default.
- W2904131963 cites W2037004764 @default.
- W2904131963 cites W2038122887 @default.
- W2904131963 cites W2076745893 @default.
- W2904131963 cites W2141345402 @default.
- W2904131963 cites W2149381364 @default.
- W2904131963 cites W2409308327 @default.
- W2904131963 cites W2588145311 @default.
- W2904131963 cites W2763859111 @default.
- W2904131963 doi "https://doi.org/10.1016/j.ijpharm.2018.11.071" @default.
- W2904131963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30529666" @default.
- W2904131963 hasPublicationYear "2019" @default.
- W2904131963 type Work @default.
- W2904131963 sameAs 2904131963 @default.
- W2904131963 citedByCount "11" @default.
- W2904131963 countsByYear W29041319632020 @default.
- W2904131963 countsByYear W29041319632021 @default.
- W2904131963 countsByYear W29041319632022 @default.
- W2904131963 countsByYear W29041319632023 @default.
- W2904131963 crossrefType "journal-article" @default.
- W2904131963 hasAuthorship W2904131963A5020922729 @default.
- W2904131963 hasAuthorship W2904131963A5029198152 @default.
- W2904131963 hasAuthorship W2904131963A5042875585 @default.
- W2904131963 hasAuthorship W2904131963A5050568819 @default.
- W2904131963 hasConcept C121332964 @default.
- W2904131963 hasConcept C127172972 @default.
- W2904131963 hasConcept C127413603 @default.
- W2904131963 hasConcept C147789679 @default.
- W2904131963 hasConcept C159985019 @default.
- W2904131963 hasConcept C178790620 @default.
- W2904131963 hasConcept C185592680 @default.
- W2904131963 hasConcept C187530423 @default.
- W2904131963 hasConcept C192562407 @default.
- W2904131963 hasConcept C2777239854 @default.
- W2904131963 hasConcept C2778445172 @default.
- W2904131963 hasConcept C2779849058 @default.
- W2904131963 hasConcept C3020410207 @default.
- W2904131963 hasConcept C42360764 @default.
- W2904131963 hasConcept C43617362 @default.
- W2904131963 hasConcept C57879066 @default.
- W2904131963 hasConcept C84199377 @default.
- W2904131963 hasConceptScore W2904131963C121332964 @default.
- W2904131963 hasConceptScore W2904131963C127172972 @default.
- W2904131963 hasConceptScore W2904131963C127413603 @default.
- W2904131963 hasConceptScore W2904131963C147789679 @default.
- W2904131963 hasConceptScore W2904131963C159985019 @default.
- W2904131963 hasConceptScore W2904131963C178790620 @default.
- W2904131963 hasConceptScore W2904131963C185592680 @default.
- W2904131963 hasConceptScore W2904131963C187530423 @default.
- W2904131963 hasConceptScore W2904131963C192562407 @default.
- W2904131963 hasConceptScore W2904131963C2777239854 @default.
- W2904131963 hasConceptScore W2904131963C2778445172 @default.
- W2904131963 hasConceptScore W2904131963C2779849058 @default.
- W2904131963 hasConceptScore W2904131963C3020410207 @default.
- W2904131963 hasConceptScore W2904131963C42360764 @default.
- W2904131963 hasConceptScore W2904131963C43617362 @default.
- W2904131963 hasConceptScore W2904131963C57879066 @default.
- W2904131963 hasConceptScore W2904131963C84199377 @default.
- W2904131963 hasLocation W29041319631 @default.
- W2904131963 hasLocation W29041319632 @default.
- W2904131963 hasOpenAccess W2904131963 @default.
- W2904131963 hasPrimaryLocation W29041319631 @default.
- W2904131963 hasRelatedWork W1996183176 @default.
- W2904131963 hasRelatedWork W2035969423 @default.
- W2904131963 hasRelatedWork W2466397386 @default.
- W2904131963 hasRelatedWork W2765509088 @default.
- W2904131963 hasRelatedWork W2799923639 @default.
- W2904131963 hasRelatedWork W2806145686 @default.
- W2904131963 hasRelatedWork W3165613415 @default.
- W2904131963 hasRelatedWork W4281656257 @default.
- W2904131963 hasRelatedWork W2186058866 @default.
- W2904131963 hasRelatedWork W2188830357 @default.
- W2904131963 hasVolume "556" @default.
- W2904131963 isParatext "false" @default.
- W2904131963 isRetracted "false" @default.
- W2904131963 magId "2904131963" @default.
- W2904131963 workType "article" @default.