FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904132512> ?p ?o ?g. }

• W2904132512 endingPage "406" @default.
• W2904132512 startingPage "398" @default.
• W2904132512 abstract "We consider a confirmatory clinical trial where a primary and a secondary endpoints are tested hierarchically to control the family-wise error rate at level α. The trial uses a group sequential design with an interim and a final analysis. When the information times at the interim analysis are the same for the primary and the secondary hypotheses, it has been shown in the literature that the secondary hypothesis has to be tested using a group sequential boundary at a level no more than α. In many event-driven trials, however, the information times are usually different because of different event rates for the two endpoints. The information times may also be different for a noninferiority hypothesis and a superiority hypothesis due to different analysis sets. We consider this general setup and derive a sharp upper bound on the probability of rejecting the secondary hypothesis at an interim and a final analysis. This bound suggests that the secondary boundary can be refined so that the group sequential design can be tested at a significance level greater than α while still controlling the family-wise error rate at level α. We carry out a simulation study to illustrate the power gain by using the refined boundary for different choices of boundaries for the two hypotheses. The proposed approach is illustrated in two oncology clinical trials with more than two analyses." @default.
• W2904132512 created "2018-12-22" @default.
• W2904132512 creator A5006118958 @default.
• W2904132512 creator A5045397534 @default.
• W2904132512 date "2019-04-09" @default.
• W2904132512 modified "2023-09-25" @default.
• W2904132512 title "Hierarchical Testing of a Primary and a Secondary Endpoint in a Group Sequential Design With Different Information Times" @default.
• W2904132512 cites W1631629704 @default.
• W2904132512 cites W1916687048 @default.
• W2904132512 cites W1936788791 @default.
• W2904132512 cites W1965970659 @default.
• W2904132512 cites W1966666962 @default.
• W2904132512 cites W1967951742 @default.
• W2904132512 cites W1980316423 @default.
• W2904132512 cites W1993632196 @default.
• W2904132512 cites W2000228459 @default.
• W2904132512 cites W2016471508 @default.
• W2904132512 cites W2027749009 @default.
• W2904132512 cites W2032208962 @default.
• W2904132512 cites W2034706348 @default.
• W2904132512 cites W2036999135 @default.
• W2904132512 cites W2043731856 @default.
• W2904132512 cites W2044403346 @default.
• W2904132512 cites W2055708265 @default.
• W2904132512 cites W2059707463 @default.
• W2904132512 cites W2069754508 @default.
• W2904132512 cites W2113019579 @default.
• W2904132512 cites W2114978670 @default.
• W2904132512 cites W2120148445 @default.
• W2904132512 cites W2127151679 @default.
• W2904132512 cites W2128596325 @default.
• W2904132512 cites W2167188058 @default.
• W2904132512 cites W2222086386 @default.
• W2904132512 cites W2530789027 @default.
• W2904132512 cites W2583075723 @default.
• W2904132512 cites W2622633411 @default.
• W2904132512 cites W2754303102 @default.
• W2904132512 cites W2755707010 @default.
• W2904132512 cites W2766394769 @default.
• W2904132512 cites W4205210034 @default.
• W2904132512 cites W4206641120 @default.
• W2904132512 cites W4242589154 @default.
• W2904132512 doi "https://doi.org/10.1080/19466315.2018.1546613" @default.
• W2904132512 hasPublicationYear "2019" @default.
• W2904132512 type Work @default.
• W2904132512 sameAs 2904132512 @default.
• W2904132512 citedByCount "14" @default.
• W2904132512 countsByYear W29041325122019 @default.
• W2904132512 countsByYear W29041325122020 @default.
• W2904132512 countsByYear W29041325122021 @default.
• W2904132512 countsByYear W29041325122023 @default.
• W2904132512 crossrefType "journal-article" @default.
• W2904132512 hasAuthorship W2904132512A5006118958 @default.
• W2904132512 hasAuthorship W2904132512A5045397534 @default.
• W2904132512 hasConcept C105795698 @default.
• W2904132512 hasConcept C121332964 @default.
• W2904132512 hasConcept C126322002 @default.
• W2904132512 hasConcept C134306372 @default.
• W2904132512 hasConcept C149782125 @default.
• W2904132512 hasConcept C166957645 @default.
• W2904132512 hasConcept C203092338 @default.
• W2904132512 hasConcept C2776957806 @default.
• W2904132512 hasConcept C2779662365 @default.
• W2904132512 hasConcept C33923547 @default.
• W2904132512 hasConcept C40696583 @default.
• W2904132512 hasConcept C41008148 @default.
• W2904132512 hasConcept C535046627 @default.
• W2904132512 hasConcept C61943457 @default.
• W2904132512 hasConcept C62354387 @default.
• W2904132512 hasConcept C62520636 @default.
• W2904132512 hasConcept C71924100 @default.
• W2904132512 hasConcept C95457728 @default.
• W2904132512 hasConceptScore W2904132512C105795698 @default.
• W2904132512 hasConceptScore W2904132512C121332964 @default.
• W2904132512 hasConceptScore W2904132512C126322002 @default.
• W2904132512 hasConceptScore W2904132512C134306372 @default.
• W2904132512 hasConceptScore W2904132512C149782125 @default.
• W2904132512 hasConceptScore W2904132512C166957645 @default.
• W2904132512 hasConceptScore W2904132512C203092338 @default.
• W2904132512 hasConceptScore W2904132512C2776957806 @default.
• W2904132512 hasConceptScore W2904132512C2779662365 @default.
• W2904132512 hasConceptScore W2904132512C33923547 @default.
• W2904132512 hasConceptScore W2904132512C40696583 @default.
• W2904132512 hasConceptScore W2904132512C41008148 @default.
• W2904132512 hasConceptScore W2904132512C535046627 @default.
• W2904132512 hasConceptScore W2904132512C61943457 @default.
• W2904132512 hasConceptScore W2904132512C62354387 @default.
• W2904132512 hasConceptScore W2904132512C62520636 @default.
• W2904132512 hasConceptScore W2904132512C71924100 @default.
• W2904132512 hasConceptScore W2904132512C95457728 @default.
• W2904132512 hasIssue "4" @default.
• W2904132512 hasLocation W29041325121 @default.
• W2904132512 hasOpenAccess W2904132512 @default.
• W2904132512 hasPrimaryLocation W29041325121 @default.
• W2904132512 hasRelatedWork W1974833954 @default.
• W2904132512 hasRelatedWork W2023402573 @default.
• W2904132512 hasRelatedWork W2059141528 @default.
• W2904132512 hasRelatedWork W2069870586 @default.

• next