Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904133051> ?p ?o ?g. }
- W2904133051 abstract "Activated invariant natural killer T (iNKT) cells rapidly produce large amounts of cytokines, but how cytokine mRNAs are induced, stabilized and mobilized following iNKT activation is still unclear. Here we show that an endoplasmic reticulum stress sensor, inositol-requiring enzyme 1α (IRE1α), links key cellular processes required for iNKT cell effector functions in specific iNKT subsets, in which TCR-dependent activation of IRE1α is associated with downstream activation of p38 MAPK and the stabilization of preformed cytokine mRNAs. Importantly, genetic deletion of IRE1α in iNKT cells reduces cytokine production and protects mice from oxazolone colitis. We therefore propose that an IRE1α-dependent signaling cascade couples constitutive cytokine mRNA expression to the rapid induction of cytokine secretion and effector functions in activated iNKT cells." @default.
- W2904133051 created "2018-12-22" @default.
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- W2904133051 date "2018-12-17" @default.
- W2904133051 modified "2023-09-26" @default.
- W2904133051 title "Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha" @default.
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- W2904133051 doi "https://doi.org/10.1038/s41467-018-07758-x" @default.
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