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• W2904133385 abstract "Background: Warfarin is an anticoagulant drug used to prevent thromboembolic disorders, but its pharmacological effect is affected by co-administered drugs. Therefore, careful management of warfarin-related drug-drug interactions (DDIs) is necessary for its safety and effectiveness. Recently, intestinal vitamin K1absorption through the Niemann-Pick C1-like 1 (NPC1L1)-mediated pathway was found to affect the pharmacological effect of warfarin. This study aimed to identify high-frequency warfarin-related DDIs in a clinical setting and elucidate their mechanism(s) in terms of changes in NPC1L1 expression and/or activity." @default.
• W2904133385 created "2018-12-22" @default.
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• W2904133385 date "2019-01-25" @default.
• W2904133385 modified "2023-10-01" @default.
• W2904133385 title "Clinical Importance of Drug-Drug Interaction Between Warfarin and Prednisolone and Its Potential Mechanism in Relation to the Niemann-Pick C1-Like 1-Mediated Pathway" @default.
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• W2904133385 doi "https://doi.org/10.1253/circj.cj-18-0807" @default.
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