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• W2904137844 endingPage "e6104" @default.
• W2904137844 startingPage "e6104" @default.
• W2904137844 abstract "The effects of age on performance of life-history traits are diverse, but a common outcome is senescence, an irreversible deterioration of physical and physiological capabilities of older individuals. Immune response is potentially bound to senescence. However, little is known about immune response ageing in amphibians. In this work, we test the hypothesis that amphibian early immune response is reduced in older individuals. To this end, we captured adult natterjack toads ( Epidalea calamita ) and inoculated them with phytohemagglutinin, an innocuous protein that triggers a skin-swelling immune response whose magnitude is directly proportional to the ability of the individual to mount an immune response. We measured early swelling immune response (corresponding to an innate-response stage) hourly, for six hours, and we calculated the area under the curve (AUC) for each individual’s time series, as a measure of immune response magnitude incorporating time. We estimated toad age by means of phalanx skeletochronology. Swelling and AUC decreased with age. Therefore, in accordance with our predictions, early immune response seems subject to senescence in these toads. Reduced ability to get over infections due to senescence of immune respose might be—together with a worse functioning of other organs and systems—among the causes of lower survival of older specimens." @default.
• W2904137844 created "2018-12-22" @default.
• W2904137844 creator A5069858256 @default.
• W2904137844 creator A5074874020 @default.
• W2904137844 date "2018-12-20" @default.
• W2904137844 modified "2023-10-17" @default.
• W2904137844 title "Early swelling response to phytohemagglutinin is lower in older toads" @default.
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• W2904137844 cites W1489838709 @default.
• W2904137844 cites W1554767992 @default.
• W2904137844 cites W1594414837 @default.
• W2904137844 cites W1658682427 @default.
• W2904137844 cites W1891228765 @default.
• W2904137844 cites W1917819114 @default.
• W2904137844 cites W1968910400 @default.
• W2904137844 cites W1975134670 @default.
• W2904137844 cites W1975761082 @default.
• W2904137844 cites W1976391651 @default.
• W2904137844 cites W1979750695 @default.
• W2904137844 cites W1981243676 @default.
• W2904137844 cites W1991711959 @default.
• W2904137844 cites W1993839684 @default.
• W2904137844 cites W1994186739 @default.
• W2904137844 cites W1994456240 @default.
• W2904137844 cites W1995836329 @default.
• W2904137844 cites W1997412308 @default.
• W2904137844 cites W2003649919 @default.
• W2904137844 cites W2006098363 @default.
• W2904137844 cites W2007302291 @default.
• W2904137844 cites W2007388291 @default.
• W2904137844 cites W2007710159 @default.
• W2904137844 cites W2011498445 @default.
• W2904137844 cites W2011767782 @default.
• W2904137844 cites W2014440105 @default.
• W2904137844 cites W2025364645 @default.
• W2904137844 cites W2027042725 @default.
• W2904137844 cites W2036516886 @default.
• W2904137844 cites W2038474461 @default.
• W2904137844 cites W2044532703 @default.
• W2904137844 cites W2049666674 @default.
• W2904137844 cites W2058341483 @default.
• W2904137844 cites W2059236074 @default.
• W2904137844 cites W2059954687 @default.
• W2904137844 cites W2061923991 @default.
• W2904137844 cites W2062869298 @default.
• W2904137844 cites W2063284856 @default.
• W2904137844 cites W2065571325 @default.
• W2904137844 cites W2065952036 @default.
• W2904137844 cites W2072823438 @default.
• W2904137844 cites W2074949522 @default.
• W2904137844 cites W2075513446 @default.
• W2904137844 cites W2078121933 @default.
• W2904137844 cites W2084466257 @default.
• W2904137844 cites W2087607820 @default.
• W2904137844 cites W2096478498 @default.
• W2904137844 cites W2097285763 @default.
• W2904137844 cites W2100733500 @default.
• W2904137844 cites W2100845642 @default.
• W2904137844 cites W2101861123 @default.
• W2904137844 cites W2104229029 @default.
• W2904137844 cites W2105394000 @default.
• W2904137844 cites W2106964828 @default.
• W2904137844 cites W2109605331 @default.
• W2904137844 cites W2109936448 @default.
• W2904137844 cites W2111349951 @default.
• W2904137844 cites W2112154467 @default.
• W2904137844 cites W2113333476 @default.
• W2904137844 cites W2115557892 @default.
• W2904137844 cites W2121966499 @default.
• W2904137844 cites W2122002245 @default.
• W2904137844 cites W2122678638 @default.
• W2904137844 cites W2126525177 @default.
• W2904137844 cites W2137102487 @default.
• W2904137844 cites W2137264901 @default.
• W2904137844 cites W2141941015 @default.
• W2904137844 cites W2144382938 @default.
• W2904137844 cites W2145484835 @default.
• W2904137844 cites W2146115576 @default.
• W2904137844 cites W2146778847 @default.
• W2904137844 cites W2156826635 @default.
• W2904137844 cites W2166318099 @default.
• W2904137844 cites W2166784550 @default.
• W2904137844 cites W2170512209 @default.
• W2904137844 cites W2172182465 @default.
• W2904137844 cites W2174285427 @default.
• W2904137844 cites W2179783171 @default.
• W2904137844 cites W2213459773 @default.
• W2904137844 cites W2514115669 @default.
• W2904137844 cites W2610616613 @default.
• W2904137844 cites W2622531811 @default.
• W2904137844 cites W2730171793 @default.
• W2904137844 cites W2754149747 @default.
• W2904137844 cites W2811114272 @default.
• W2904137844 doi "https://doi.org/10.7717/peerj.6104" @default.
• W2904137844 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6304268" @default.
• W2904137844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30595980" @default.
• W2904137844 hasPublicationYear "2018" @default.
• W2904137844 type Work @default.

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