Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904138000> ?p ?o ?g. }
- W2904138000 endingPage "8522" @default.
- W2904138000 startingPage "8507" @default.
- W2904138000 abstract "Liposome delivery systems for the treatment of Alzheimer's disease Callum Ross, Mark Taylor, Nigel Fullwood, David Allsop Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YQ, UK Abstract: Alzheimer’s disease (AD) will affect around 115 million people worldwide by the year 2050. It is associated with the accumulation of misfolded and aggregated proteins (β-amyloid and tau) in the senile plaques and neurofibrillary tangles found in the brain. Currently available drugs for AD only temporarily alleviate symptoms and do not slow the inevitable progression of this disease. New drugs are required that act on key pathologies in order to arrest or reverse cognitive decline. However, there has been a spectacular failure rate in clinical trials of conventional small molecule drugs or biological agents. Targeted nanoliposomes represent a viable and promising drug delivery system for AD that have not yet reached clinical trials. They are biocompatible, highly flexible, and have the potential to carry many different types of therapeutic molecules across the blood–brain barrier (BBB) and into brain cells. They can be tailored to extend blood circulation time and can be directed against individual or multiple pathological targets. Modifications so far have included the use of brain-penetrating peptides, together with Aβ-targeting ligands, such as phosphatidic acid, curcumin, and a retro-inverted peptide that inhibits Aβ aggregation. Combining several modifications together into multifunctional liposomes is currently a research area of great interest. This review focuses on recent liposomal approaches to AD therapy, including mechanisms involved in facilitating their passage across the BBB, and the evaluation of new therapeutic agents for blocking Aβ and/or tau aggregation. Keywords: amyloid, blood–brain barrier, cell-penetrating peptides, neurofibrillary tangles, senile plaques, tau" @default.
- W2904138000 created "2018-12-22" @default.
- W2904138000 creator A5020554752 @default.
- W2904138000 creator A5046887318 @default.
- W2904138000 creator A5061867098 @default.
- W2904138000 creator A5091196474 @default.
- W2904138000 date "2018-12-01" @default.
- W2904138000 modified "2023-10-11" @default.
- W2904138000 title "Liposome delivery systems for the treatment of Alzheimer’s disease" @default.
- W2904138000 cites W1178578580 @default.
- W2904138000 cites W127634720 @default.
- W2904138000 cites W1488196605 @default.
- W2904138000 cites W1534854046 @default.
- W2904138000 cites W1574601702 @default.
- W2904138000 cites W1584683177 @default.
- W2904138000 cites W1605885548 @default.
- W2904138000 cites W1629345865 @default.
- W2904138000 cites W1714678118 @default.
- W2904138000 cites W1786633887 @default.
- W2904138000 cites W1819221371 @default.
- W2904138000 cites W1964117773 @default.
- W2904138000 cites W1966342087 @default.
- W2904138000 cites W1968682237 @default.
- W2904138000 cites W1970624300 @default.
- W2904138000 cites W1972844855 @default.
- W2904138000 cites W1974594097 @default.
- W2904138000 cites W1979808034 @default.
- W2904138000 cites W1980011839 @default.
- W2904138000 cites W1980825524 @default.
- W2904138000 cites W1981009270 @default.
- W2904138000 cites W1982541881 @default.
- W2904138000 cites W1985222229 @default.
- W2904138000 cites W1987204546 @default.
- W2904138000 cites W1987843843 @default.
- W2904138000 cites W1989165356 @default.
- W2904138000 cites W1989557252 @default.
- W2904138000 cites W1991720510 @default.
- W2904138000 cites W1995370236 @default.
- W2904138000 cites W2002311445 @default.
- W2904138000 cites W2003726414 @default.
- W2904138000 cites W2006734683 @default.
- W2904138000 cites W2014150467 @default.
- W2904138000 cites W2018340655 @default.
- W2904138000 cites W2019629829 @default.
- W2904138000 cites W2021683757 @default.
- W2904138000 cites W2025540948 @default.
- W2904138000 cites W2028432634 @default.
- W2904138000 cites W2028672439 @default.
- W2904138000 cites W2034968148 @default.
- W2904138000 cites W2037571189 @default.
- W2904138000 cites W2038067778 @default.
- W2904138000 cites W2041187942 @default.
- W2904138000 cites W2047472097 @default.
- W2904138000 cites W2048110346 @default.
- W2904138000 cites W2048497409 @default.
- W2904138000 cites W2049259355 @default.
- W2904138000 cites W2052419122 @default.
- W2904138000 cites W2055937873 @default.
- W2904138000 cites W2056272101 @default.
- W2904138000 cites W2059734091 @default.
- W2904138000 cites W2064296617 @default.
- W2904138000 cites W2064367582 @default.
- W2904138000 cites W2065294305 @default.
- W2904138000 cites W2067106749 @default.
- W2904138000 cites W2074421138 @default.
- W2904138000 cites W2075771522 @default.
- W2904138000 cites W2076949199 @default.
- W2904138000 cites W2077128382 @default.
- W2904138000 cites W2077134890 @default.
- W2904138000 cites W2077412466 @default.
- W2904138000 cites W2077931808 @default.
- W2904138000 cites W2078344908 @default.
- W2904138000 cites W2080182688 @default.
- W2904138000 cites W2080512444 @default.
- W2904138000 cites W2081275347 @default.
- W2904138000 cites W2082371846 @default.
- W2904138000 cites W2083327214 @default.
- W2904138000 cites W2083492332 @default.
- W2904138000 cites W2083537472 @default.
- W2904138000 cites W2084972185 @default.
- W2904138000 cites W2085873658 @default.
- W2904138000 cites W2086107480 @default.
- W2904138000 cites W2096410114 @default.
- W2904138000 cites W2103647454 @default.
- W2904138000 cites W2110569992 @default.
- W2904138000 cites W2121515004 @default.
- W2904138000 cites W2123650819 @default.
- W2904138000 cites W2127582578 @default.
- W2904138000 cites W2128480199 @default.
- W2904138000 cites W2131674335 @default.
- W2904138000 cites W2133167758 @default.
- W2904138000 cites W2138070279 @default.
- W2904138000 cites W2138967764 @default.
- W2904138000 cites W2144196643 @default.
- W2904138000 cites W2146029618 @default.
- W2904138000 cites W2147400963 @default.
- W2904138000 cites W2151091220 @default.
- W2904138000 cites W2158748165 @default.