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• W2904138510 abstract "Patients undergoing the complex treatment for hematological malignancies are exposed to a high physiological and psychological distress inducing fatigue and physical inactivity. In line with cancer-related metabolic changes patients are predisposed for skeletal muscle mass loss that leads to a functional decline, affects therapeutic success and quality of life. Benefits of physical exercise and nutritional interventions on muscle maintenance are observed in solid cancer patients, but marginally investigated in patients with hematological cancer. We here studied the effects of a combined supportive exercise and nutrition intervention using whole-body electromyostimulation (WB-EMS) training and individualized nutritional support in patients actively treated for hematological malignancy. In a controlled pilot trial, 31 patients (67.7% male; 58.0±16.7 years) with various hematological cancers were allocated to a control group (n=9) receiving nutritional support of usual care regarding a high protein intake (> 1.0 g/kg/d) or to a physical exercise group (n=22) additionally performing WB-EMS training twice weekly for 12 weeks. Bodyweight and body composition assessed by bioelectrical impedance analysis were measured every four weeks. Physical function, blood parameters, quality of life and fatigue were assessed at baseline and after 12 weeks. No WB-EMS-related adverse effects occurred. Patients attending the exercise program presented a higher skeletal muscle mass than controls after 12-weeks (1.51 kg [0.41, 2.60]; p=0.008). In contrast, patients of the control group showed a higher fat mass percentage than patients of the WB-EMS group (-4.46% [-7.15, -1.77]; p=0.001) that was accompanied by an increase in serum triglycerides in contrast to a decrease in the WB-EMS group (change±SD, control 36.3±50.6 mg/dl; WB EMS -31.8±68.7 mg/dl; p=0.064). No significant group differences for lower limb strength, quality of life and fatigue were detected. However, compared to controls the WB-EMS group significantly improved in physical functioning indicated by a higher increase in the six-minute-walking distance (p=0.046). A combined therapeutic intervention of WB-EMS and protein-rich nutritional support seems to be safe and effective in improving skeletal muscle mass and body composition in hematological cancer patients during active oncological treatment. Clinical Trial Registry Number: NCT02293239 Registered at: www.clinicaltrials.gov/" @default.
• W2904138510 created "2018-12-22" @default.
• W2904138510 creator A5007909391 @default.
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• W2904138510 date "2018-12-18" @default.
• W2904138510 modified "2023-09-30" @default.
• W2904138510 title "Whole-Body Electromyostimulation Combined With Individualized Nutritional Support Improves Body Composition in Patients With Hematological Malignancies – A Pilot Study" @default.
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• W2904138510 doi "https://doi.org/10.3389/fphys.2018.01808" @default.
• W2904138510 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6305403" @default.
• W2904138510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30618820" @default.
• W2904138510 hasPublicationYear "2018" @default.
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• W2904138510 hasAuthorship W2904138510A5007909391 @default.
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• W2904138510 hasAuthorship W2904138510A5039793753 @default.

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