Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904142242> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2904142242 endingPage "43" @default.
- W2904142242 startingPage "36" @default.
- W2904142242 abstract "Tablets are increasingly explored as dosage form for oral probiotics, especially for applications such as pharyngitis and dental health. In such tablets, the dry form increases the stability and the shelf life of the product. In addition, the probiotic cells are entrapped in the tablet matrix, which protects them against the environmental factors in the human body. However, the development of a probiotic tablet with an adequate number of viable cells remains a challenge due to the stress of the compression process. The adverse conditions during production can damage the cells, which leads to a loss of viability and a failure of the therapy. This study aimed to investigate the effect of the compression behavior of filler-binders on the survival of Lactobacillus rhamnosus GG during tablet production. The probiotic tablets were manufactured by direct compression of a freeze-dried mixture of the model L. rhamnosus GG, a filler-binder and a suitable amount of lubricant. The compression behavior was determined by analyzing Heckel and force-displacement plots. The results demonstrated that the elastic recovery of the filler-binder during decompression played a protective role in bacterial survival, reducing the compression stress during manufacturing. Consequently, the bacterial cells were less damaged, which resulted in a higher survival rate and a better stability during long-term storage. In conclusion, the elastic recovery of a filler-binder showed to be an important key in safeguarding probiotic cells during direct compression and storage." @default.
- W2904142242 created "2018-12-22" @default.
- W2904142242 creator A5064243269 @default.
- W2904142242 creator A5069724602 @default.
- W2904142242 creator A5070470113 @default.
- W2904142242 date "2019-02-01" @default.
- W2904142242 modified "2023-09-26" @default.
- W2904142242 title "Elastic recovery of filler-binders to safeguard viability of Lactobacillus rhamnosus GG during direct compression" @default.
- W2904142242 cites W1970002581 @default.
- W2904142242 cites W1970642622 @default.
- W2904142242 cites W1973172403 @default.
- W2904142242 cites W1984274062 @default.
- W2904142242 cites W1985265985 @default.
- W2904142242 cites W1987709728 @default.
- W2904142242 cites W1992980458 @default.
- W2904142242 cites W1998089412 @default.
- W2904142242 cites W2000895608 @default.
- W2904142242 cites W2015136749 @default.
- W2904142242 cites W2028560988 @default.
- W2904142242 cites W2037114845 @default.
- W2904142242 cites W2042280270 @default.
- W2904142242 cites W2044458904 @default.
- W2904142242 cites W2048267974 @default.
- W2904142242 cites W2053153816 @default.
- W2904142242 cites W2068904931 @default.
- W2904142242 cites W2079953061 @default.
- W2904142242 cites W2107606668 @default.
- W2904142242 cites W2143252385 @default.
- W2904142242 cites W2772873851 @default.
- W2904142242 cites W2799841786 @default.
- W2904142242 doi "https://doi.org/10.1016/j.ejpb.2018.12.005" @default.
- W2904142242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30543948" @default.
- W2904142242 hasPublicationYear "2019" @default.
- W2904142242 type Work @default.
- W2904142242 sameAs 2904142242 @default.
- W2904142242 citedByCount "8" @default.
- W2904142242 countsByYear W29041422422019 @default.
- W2904142242 countsByYear W29041422422020 @default.
- W2904142242 countsByYear W29041422422021 @default.
- W2904142242 countsByYear W29041422422023 @default.
- W2904142242 crossrefType "journal-article" @default.
- W2904142242 hasAuthorship W2904142242A5064243269 @default.
- W2904142242 hasAuthorship W2904142242A5069724602 @default.
- W2904142242 hasAuthorship W2904142242A5070470113 @default.
- W2904142242 hasBestOaLocation W29041422422 @default.
- W2904142242 hasConcept C100544194 @default.
- W2904142242 hasConcept C159985019 @default.
- W2904142242 hasConcept C180016635 @default.
- W2904142242 hasConcept C185592680 @default.
- W2904142242 hasConcept C192562407 @default.
- W2904142242 hasConcept C2776651480 @default.
- W2904142242 hasConcept C2778223994 @default.
- W2904142242 hasConcept C2780206646 @default.
- W2904142242 hasConcept C2780255968 @default.
- W2904142242 hasConcept C2785061 @default.
- W2904142242 hasConcept C31903555 @default.
- W2904142242 hasConcept C523546767 @default.
- W2904142242 hasConcept C54355233 @default.
- W2904142242 hasConcept C86803240 @default.
- W2904142242 hasConceptScore W2904142242C100544194 @default.
- W2904142242 hasConceptScore W2904142242C159985019 @default.
- W2904142242 hasConceptScore W2904142242C180016635 @default.
- W2904142242 hasConceptScore W2904142242C185592680 @default.
- W2904142242 hasConceptScore W2904142242C192562407 @default.
- W2904142242 hasConceptScore W2904142242C2776651480 @default.
- W2904142242 hasConceptScore W2904142242C2778223994 @default.
- W2904142242 hasConceptScore W2904142242C2780206646 @default.
- W2904142242 hasConceptScore W2904142242C2780255968 @default.
- W2904142242 hasConceptScore W2904142242C2785061 @default.
- W2904142242 hasConceptScore W2904142242C31903555 @default.
- W2904142242 hasConceptScore W2904142242C523546767 @default.
- W2904142242 hasConceptScore W2904142242C54355233 @default.
- W2904142242 hasConceptScore W2904142242C86803240 @default.
- W2904142242 hasFunder F4320321730 @default.
- W2904142242 hasLocation W29041422421 @default.
- W2904142242 hasLocation W29041422422 @default.
- W2904142242 hasLocation W29041422423 @default.
- W2904142242 hasOpenAccess W2904142242 @default.
- W2904142242 hasPrimaryLocation W29041422421 @default.
- W2904142242 hasRelatedWork W1603321918 @default.
- W2904142242 hasRelatedWork W2025350806 @default.
- W2904142242 hasRelatedWork W2080394264 @default.
- W2904142242 hasRelatedWork W2413640550 @default.
- W2904142242 hasRelatedWork W2565387770 @default.
- W2904142242 hasRelatedWork W2568584433 @default.
- W2904142242 hasRelatedWork W2768412420 @default.
- W2904142242 hasRelatedWork W2904142242 @default.
- W2904142242 hasRelatedWork W2911208873 @default.
- W2904142242 hasRelatedWork W3046177357 @default.
- W2904142242 hasVolume "135" @default.
- W2904142242 isParatext "false" @default.
- W2904142242 isRetracted "false" @default.
- W2904142242 magId "2904142242" @default.
- W2904142242 workType "article" @default.