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• W2904161771 abstract "In seed plants, pollen grains carry the male gametes to female structures. They are frequent in the ambient air, and cause airway inflammation in one out of four persons in the population. This potency was traditionally attributed to soluble glycoproteins, that leak out from the grains into the moist nasal mucosa or into the conjunctiva, and that are able to bind antibodies. It is now more and more recognised that apart from proteins, also other immunomodulating compounds are present. Lipids bind to Toll-like and CD1 receptors on antigen-presenting cells in the mammal immune system, and are able to induce a Type 2 reaction in effector cells. They may also mimic lipid mediators from mammal mast cells. Pollen grains have a rich lipodome of their own. Among the lipids that have been associated with an atopic reaction are saturated and unsaturated fatty acids, glycophospholipids, sphingolipids, sterols, and oxylipids, as well as lipopolysaccharides from the microbiome on the pollen surface. Lipids can be ligands to allergenic proteins." @default.
• W2904161771 created "2018-12-22" @default.
• W2904161771 creator A5057137511 @default.
• W2904161771 date "2018-12-11" @default.
• W2904161771 modified "2023-10-18" @default.
• W2904161771 title "Pollen Lipids Can Play a Role in Allergic Airway Inflammation" @default.
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• W2904161771 doi "https://doi.org/10.3389/fimmu.2018.02816" @default.
• W2904161771 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6297749" @default.
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• W2904161771 hasPublicationYear "2018" @default.
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