FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904161812> ?p ?o ?g. }

• W2904161812 abstract "Background: HOXA10 is a key transcriptional factor that regulates testis development as reported from previous transgenic mouse models and human inherited diseases. However, whether it also plays important roles in promoting the development of testicular cancer is not well-understood. Objective: To study the expression of HOXA10 and its regulated signaling pathways in testicular cancers. Design, Setting, and Participants: A tissue microarray was constructed with benign and cancerous testis. TCam2, NT-2, and NCCIT cell models were applied in this study. Intervention: Immunohistochemistry and immunofluorescence were performed to measure the expression and cellular localization of HOXA10 in testicular cancer tissues and cell models. Cell proliferation and cell cycling rates were determined by BrdU incorporation and flow cytometry assays. HOXA10 transcriptomes were profiled with Ampliseq RNA-seq in testicular cancer cells. Immunoblotting assays were used to detect HOXA10-regulated signaling. Results: HOXA10 is a nuclear protein in benign spermatocytes. Reduced nuclear expression and increased cytoplasmic expression of HOXA10 are associated with testicular cancers. These changes are consistent in both seminoma and non-seminoma. Enhanced HOXA10 expression in testicular cancer cell models inhibits cell proliferation and delays cell cycle progression through G2/M phases. These functions of HOXA10 mainly affect the TP53, cKit, STAT3, AKT, and ERK signaling pathways. Conclusions: Loss of nuclear functions of HOXA10 enhances proliferation of testicular cancer cells, suggesting that downregulation of HOXA10 transcription activity may promote the development of testicular cancers." @default.
• W2904161812 created "2018-12-22" @default.
• W2904161812 creator A5000093771 @default.
• W2904161812 creator A5034110828 @default.
• W2904161812 creator A5062125605 @default.
• W2904161812 creator A5073827712 @default.
• W2904161812 creator A5079552709 @default.
• W2904161812 creator A5086407520 @default.
• W2904161812 creator A5088592356 @default.
• W2904161812 date "2018-12-07" @default.
• W2904161812 modified "2023-10-17" @default.
• W2904161812 title "Loss of Nuclear Functions of HOXA10 Is Associated With Testicular Cancer Proliferation" @default.
• W2904161812 cites W127597761 @default.
• W2904161812 cites W1561162929 @default.
• W2904161812 cites W1775554231 @default.
• W2904161812 cites W1955008898 @default.
• W2904161812 cites W1962964452 @default.
• W2904161812 cites W1967880683 @default.
• W2904161812 cites W1973110404 @default.
• W2904161812 cites W2002061253 @default.
• W2904161812 cites W2003106200 @default.
• W2904161812 cites W2007315553 @default.
• W2904161812 cites W2015372812 @default.
• W2904161812 cites W2034928090 @default.
• W2904161812 cites W2038676896 @default.
• W2904161812 cites W2047855715 @default.
• W2904161812 cites W2048249977 @default.
• W2904161812 cites W2060515433 @default.
• W2904161812 cites W2061633616 @default.
• W2904161812 cites W2066171378 @default.
• W2904161812 cites W2075265441 @default.
• W2904161812 cites W2076534093 @default.
• W2904161812 cites W2079792488 @default.
• W2904161812 cites W2102594480 @default.
• W2904161812 cites W2109081811 @default.
• W2904161812 cites W2110439369 @default.
• W2904161812 cites W2112703600 @default.
• W2904161812 cites W2119857211 @default.
• W2904161812 cites W2122676947 @default.
• W2904161812 cites W2141384566 @default.
• W2904161812 cites W2144674849 @default.
• W2904161812 cites W2147751805 @default.
• W2904161812 cites W2155038007 @default.
• W2904161812 cites W2159465869 @default.
• W2904161812 cites W2162919508 @default.
• W2904161812 cites W2168834363 @default.
• W2904161812 cites W2170858162 @default.
• W2904161812 cites W2179438025 @default.
• W2904161812 cites W2202473697 @default.
• W2904161812 cites W2331816360 @default.
• W2904161812 cites W2356434884 @default.
• W2904161812 cites W2517667217 @default.
• W2904161812 cites W2523469334 @default.
• W2904161812 cites W2533324512 @default.
• W2904161812 cites W2538727120 @default.
• W2904161812 cites W2624983637 @default.
• W2904161812 cites W2724458594 @default.
• W2904161812 cites W2736533590 @default.
• W2904161812 cites W2780415411 @default.
• W2904161812 cites W2789740887 @default.
• W2904161812 cites W2795344127 @default.
• W2904161812 cites W2893327873 @default.
• W2904161812 cites W4211162622 @default.
• W2904161812 doi "https://doi.org/10.3389/fonc.2018.00594" @default.
• W2904161812 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6292994" @default.
• W2904161812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30581773" @default.
• W2904161812 hasPublicationYear "2018" @default.
• W2904161812 type Work @default.
• W2904161812 sameAs 2904161812 @default.
• W2904161812 citedByCount "12" @default.
• W2904161812 countsByYear W29041618122019 @default.
• W2904161812 countsByYear W29041618122020 @default.
• W2904161812 countsByYear W29041618122021 @default.
• W2904161812 countsByYear W29041618122022 @default.
• W2904161812 crossrefType "journal-article" @default.
• W2904161812 hasAuthorship W2904161812A5000093771 @default.
• W2904161812 hasAuthorship W2904161812A5034110828 @default.
• W2904161812 hasAuthorship W2904161812A5062125605 @default.
• W2904161812 hasAuthorship W2904161812A5073827712 @default.
• W2904161812 hasAuthorship W2904161812A5079552709 @default.
• W2904161812 hasAuthorship W2904161812A5086407520 @default.
• W2904161812 hasAuthorship W2904161812A5088592356 @default.
• W2904161812 hasBestOaLocation W29041618121 @default.
• W2904161812 hasConcept C121608353 @default.
• W2904161812 hasConcept C153911025 @default.
• W2904161812 hasConcept C2776694085 @default.
• W2904161812 hasConcept C2778074268 @default.
• W2904161812 hasConcept C29537977 @default.
• W2904161812 hasConcept C502942594 @default.
• W2904161812 hasConcept C54355233 @default.
• W2904161812 hasConcept C553184892 @default.
• W2904161812 hasConcept C62112901 @default.
• W2904161812 hasConcept C86803240 @default.
• W2904161812 hasConceptScore W2904161812C121608353 @default.
• W2904161812 hasConceptScore W2904161812C153911025 @default.
• W2904161812 hasConceptScore W2904161812C2776694085 @default.
• W2904161812 hasConceptScore W2904161812C2778074268 @default.
• W2904161812 hasConceptScore W2904161812C29537977 @default.
• W2904161812 hasConceptScore W2904161812C502942594 @default.
• W2904161812 hasConceptScore W2904161812C54355233 @default.

• next