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- W2904163206 abstract "Pregnancy reduces the frequency of relapses in Multiple Sclerosis (MS) and parity also has a beneficial long term effect on disease outcome. We aimed to uncover the biological mechanisms underlying the beneficial long-term effects of parity in MS. Genome-wide gene expression revealed 574 genes associated with parity; 38.3% showed significant DNA methylation changes (enrichment p = 0.029). These genes overlapped with previous MS genes in humans and a rat MS model and were overrepresented within axon guidance (P = 1.6e-05), developmental biology (P = 0.0094) and cell-cell communication (P = 0.019) pathways. This gene regulation could provide a basis for a protective effect of parity on the long-term outcome of MS." @default.
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- W2904163206 date "2019-03-01" @default.
- W2904163206 modified "2023-09-25" @default.
- W2904163206 title "Cumulative influence of parity-related genomic changes in multiple sclerosis" @default.
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- W2904163206 doi "https://doi.org/10.1016/j.jneuroim.2018.12.004" @default.
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