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• W2904163757 abstract "ABSTRACT Competence for genetic transformation allows the opportunistic human pathogen Streptococcus pneumoniae to take up exogenous DNA for incorporation into its own genome. This ability may account for the extraordinary genomic plasticity of this bacterium, leading to antigenic variation, vaccine escape, and the spread of antibiotic resistance markers. The competence system has been thoroughly studied and its regulation is well-understood. Additionally, over the last decade, several stress factors have been shown to trigger the competent state, leading to the activation of several stress response regulons. The arrival of next-generation sequencing techniques allowed us to update the competence regulon, the latest report of which still depended on DNA microarray technology. Enabled by the availability of an up-to-date genome annotation, including transcript boundaries, we assayed time-dependent expression of all annotated features in response to competence induction, were able to identify the affected promoters and produced a more complete overview of the various regulons activated during competence. We show that 4% of all annotated genes are under direct control of competence regulators ComE and ComX, while the expression of a total of up to 17% of all genes is, either directly or indirectly, affected. Among the affected genes are various small RNAs with an as-of-yet unknown function. Besides the ComE and ComX regulons, we were also able to refine the CiaR, VraR (LiaR) and BlpR regulons, underlining the strength of combining RNA-seq with a well-annotated genome." @default.
• W2904163757 created "2018-12-22" @default.
• W2904163757 creator A5021934828 @default.
• W2904163757 creator A5054257103 @default.
• W2904163757 creator A5090662195 @default.
• W2904163757 date "2018-12-14" @default.
• W2904163757 modified "2023-10-12" @default.
• W2904163757 title "Refining the pneumococcal competence regulon by RNA-sequencing" @default.
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• W2904163757 doi "https://doi.org/10.1101/497099" @default.
• W2904163757 hasPublicationYear "2018" @default.
• W2904163757 type Work @default.
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• W2904163757 hasAuthorship W2904163757A5021934828 @default.

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