FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904166623> ?p ?o ?g. }

• W2904166623 endingPage "370" @default.
• W2904166623 startingPage "356" @default.
• W2904166623 abstract "The current study investigated the role of guggulsterone (GS), a farnesoid X receptor antagonist, in the choline metabolism and its trimethylamine (TMA)/flavin monooxygenases/trimethylamine- N-oxide (TMAO) inhibiting potential in a series of in vitro and in vivo studies as determined by high-performance liquid chromatography (HPLC), mass spectroscopy (MS), and liquid chromatography (LC)-MS techniques. Atherosclerosis (AS) was successfully induced in a group of experimental animals fed with 2% choline diet for 6 weeks. Serum lipid profiles such as total cholesterol, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and very low-density lipoprotein cholesterol were measured. Pro-inflammatory cytokines levels, markers for a hepatic injury, and oxidative stress markers were assessed. Interestingly, GS reduced the level of TMA/TMAO in both in vitro and in vivo studies as demonstrated by the peaks obtained from HPLC, MS, and LC–MS. Furthermore, GS exhibited cardioprotective and antihyperlipidemic effects as evidenced by the attenuation of levels of several serum lipid profiles and different atherogenic risk predictor indexes. GS also prevented hepatic injury by successfully restoring the levels of hepatic injury biomarkers to normal. Similarly, GS inhibited the production of pro-inflammatory cytokines levels, as well as GS, enhanced antioxidant capacity, and reduced lipid peroxidation. Histopathological study of aortic sections demonstrated that GS maintained the normal architecture in AS-induced rats. On the basis of results obtained from current investigation, we suggest that GS might have a great therapeutic potential for the treatment of AS." @default.
• W2904166623 created "2018-12-22" @default.
• W2904166623 creator A5030133655 @default.
• W2904166623 creator A5055529892 @default.
• W2904166623 creator A5057696579 @default.
• W2904166623 creator A5083162439 @default.
• W2904166623 date "2018-12-09" @default.
• W2904166623 modified "2023-09-26" @default.
• W2904166623 title "Guggulsterone, a farnesoid X receptor antagonist lowers plasma trimethylamine-<i>N</i>-oxide levels: An evidence from in vitro and in vivo studies" @default.
• W2904166623 cites W1489131400 @default.
• W2904166623 cites W1966924888 @default.
• W2904166623 cites W1989744486 @default.
• W2904166623 cites W1992152105 @default.
• W2904166623 cites W1992663882 @default.
• W2904166623 cites W2012606594 @default.
• W2904166623 cites W2016019060 @default.
• W2904166623 cites W2033896075 @default.
• W2904166623 cites W2035576567 @default.
• W2904166623 cites W2035837169 @default.
• W2904166623 cites W2043900297 @default.
• W2904166623 cites W2046316092 @default.
• W2904166623 cites W2046971089 @default.
• W2904166623 cites W2047311850 @default.
• W2904166623 cites W2052237041 @default.
• W2904166623 cites W2052725031 @default.
• W2904166623 cites W2061755142 @default.
• W2904166623 cites W2078599166 @default.
• W2904166623 cites W2109760671 @default.
• W2904166623 cites W2115944543 @default.
• W2904166623 cites W2119343060 @default.
• W2904166623 cites W2122043662 @default.
• W2904166623 cites W2124507080 @default.
• W2904166623 cites W2142423845 @default.
• W2904166623 cites W2144022915 @default.
• W2904166623 cites W2150350691 @default.
• W2904166623 cites W2162078360 @default.
• W2904166623 cites W2295882128 @default.
• W2904166623 cites W2333052165 @default.
• W2904166623 cites W2485153924 @default.
• W2904166623 cites W2485225030 @default.
• W2904166623 cites W2495627383 @default.
• W2904166623 cites W2558726333 @default.
• W2904166623 cites W2580127642 @default.
• W2904166623 cites W2616059982 @default.
• W2904166623 cites W2738657730 @default.
• W2904166623 cites W2784250532 @default.
• W2904166623 cites W2804575956 @default.
• W2904166623 cites W3010265501 @default.
• W2904166623 doi "https://doi.org/10.1177/0960327118817862" @default.
• W2904166623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30526076" @default.
• W2904166623 hasPublicationYear "2018" @default.
• W2904166623 type Work @default.
• W2904166623 sameAs 2904166623 @default.
• W2904166623 citedByCount "16" @default.
• W2904166623 countsByYear W29041666232019 @default.
• W2904166623 countsByYear W29041666232020 @default.
• W2904166623 countsByYear W29041666232021 @default.
• W2904166623 countsByYear W29041666232022 @default.
• W2904166623 countsByYear W29041666232023 @default.
• W2904166623 crossrefType "journal-article" @default.
• W2904166623 hasAuthorship W2904166623A5030133655 @default.
• W2904166623 hasAuthorship W2904166623A5055529892 @default.
• W2904166623 hasAuthorship W2904166623A5057696579 @default.
• W2904166623 hasAuthorship W2904166623A5083162439 @default.
• W2904166623 hasConcept C104317684 @default.
• W2904166623 hasConcept C126322002 @default.
• W2904166623 hasConcept C134018914 @default.
• W2904166623 hasConcept C150903083 @default.
• W2904166623 hasConcept C178790620 @default.
• W2904166623 hasConcept C185592680 @default.
• W2904166623 hasConcept C203862802 @default.
• W2904166623 hasConcept C207001950 @default.
• W2904166623 hasConcept C2776149385 @default.
• W2904166623 hasConcept C2776151105 @default.
• W2904166623 hasConcept C2778163477 @default.
• W2904166623 hasConcept C2780072125 @default.
• W2904166623 hasConcept C2780541478 @default.
• W2904166623 hasConcept C2780829032 @default.
• W2904166623 hasConcept C2780924926 @default.
• W2904166623 hasConcept C2781123555 @default.
• W2904166623 hasConcept C519581460 @default.
• W2904166623 hasConcept C55493867 @default.
• W2904166623 hasConcept C63932345 @default.
• W2904166623 hasConcept C71924100 @default.
• W2904166623 hasConcept C86339819 @default.
• W2904166623 hasConcept C86803240 @default.
• W2904166623 hasConcept C98274493 @default.
• W2904166623 hasConceptScore W2904166623C104317684 @default.
• W2904166623 hasConceptScore W2904166623C126322002 @default.
• W2904166623 hasConceptScore W2904166623C134018914 @default.
• W2904166623 hasConceptScore W2904166623C150903083 @default.
• W2904166623 hasConceptScore W2904166623C178790620 @default.
• W2904166623 hasConceptScore W2904166623C185592680 @default.
• W2904166623 hasConceptScore W2904166623C203862802 @default.
• W2904166623 hasConceptScore W2904166623C207001950 @default.
• W2904166623 hasConceptScore W2904166623C2776149385 @default.
• W2904166623 hasConceptScore W2904166623C2776151105 @default.
• W2904166623 hasConceptScore W2904166623C2778163477 @default.

• next