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- W2904171803 abstract "Age-related cognitive changes in the Russian population have not been sufficiently studied. Objective : to assess the time course of changes in cognitive functions (CF) in two serial measurements 9 years apart in the urban population of middle, elder, and senile age and their relationship to education level. Patients and methods . A random male and female sample of45-69-year-old Novosibirsk residents (n=9360; HAPIEE project) was surveyed. CF was tested by standard methods. Resurvey was conducted in a random subsample (n=1663) included in this analysis. The mean follow-up period was 8.8 years (SD 1.1). Results and discussion . The test for semantic verbal fluency revealed its dynamic decline in all age groups, which was steeper in women than in men (p<0.001). Persons aged 70 years and older showed negative changes in memory, verbal fluency, and attention (p<0.001). Persons with primary (6%) and vocational (26%) education had steeper rates of decline in delayed recall (p=0.011; 0.038) than those with university education (35%). Conclusion. It is established that a dynamic decrease in CF begins at the age of55—59years; it is steeper among those aged 70 years and older. An age-related decline in memory function is accelerated in persons with lower educational levels." @default.
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- W2904171803 date "2018-12-15" @default.
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- W2904171803 title "Research Institute of Internal and Preventive Medicine, Branch, Federal Research Center, Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences" @default.
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- W2904171803 doi "https://doi.org/10.14412/2074-2711-2018-4-46-51" @default.
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