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- W2904174920 abstract "An efficient double Friedel‐Crafts alkylation strategy has been developed for the synthesis of 2,2‐bis(1,2,3,4‐tetrahydroquinolin‐6‐yl)acetates from N ‐arylglycine esters using 10 mol‐% CuI in water as solvent. The reaction presumably involves α‐C‐H bond functionalization and concurrent nucleophilic substitution of the N ‐arylglycine esters producing double Friedel‐Crafts alkylation products. The reaction protocol is successfully extended for N ‐methyl aniline and indole nucleophiles." @default.
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- W2904174920 date "2019-01-11" @default.
- W2904174920 modified "2023-09-25" @default.
- W2904174920 title "Copper‐Catalyzed Double Friedel‐Crafts Alkylation of Tetrahydroquinolines Under Aqueous Conditions: Efficient Synthesis of gem‐Diarylacetic Esters" @default.
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- W2904174920 doi "https://doi.org/10.1002/ejoc.201801369" @default.
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