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• W2904178174 abstract "Abstract In the past few years, the discovery of epidermal growth factor receptor (EGFR) activating mutations and the demonstration of efficacy of EGFR tyrosine kinase inhibitors (TKIs) have revolutionized the algorithm of diagnosis and treatment of non-small cell lung cancer (NSCLC), marking the advent of the era of precision medicine. Several phase III studies have demonstrated the effectiveness of EGFR TKIs, becoming standard therapy for patients with EGFR mutant NSCLC. Unfortunately, despite important results in terms of response and progression-free survival with these drugs, generally, after a median of 11 months of treatment, all patients become refractory to treatment, developing an acquired resistance due to the so-called T790M mutation. Second- and third-generation EGFR TKIs have been developed to overcome acquired resistance, showing interesting results both in second- and in first-line setting." @default.
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• W2904178174 date "2019-01-01" @default.
• W2904178174 modified "2023-09-26" @default.
• W2904178174 title "EGFR Mutations" @default.
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• W2904178174 doi "https://doi.org/10.1016/b978-0-12-811785-9.00033-8" @default.
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