FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904178552> ?p ?o ?g. }

• W2904178552 abstract "The appearance of endogenous tyrosine hydroxylase-positive cells (TH+ cells) in collagen-induced arthritis was associated with an anti-inflammatory effect. Here we investigated putative anti-inflammatory and antinociceptive effects of the transfer of induced, bone marrow stem cell-derived TH+ cells (iTH+ cells) on murine antigen-induced arthritis (AIA).Bone marrow-derived stem cells were differentiated into iTH+ cells. These cells were transferred to mice immunized against methylated bovine serum albumin (mBSA) 2 days before AIA was induced by injection of mBSA into one knee joint. In AIA control mice and iTH+-treated mice the severity of AIA, pain-related behavior, humoral and cellular responses, and the invasion of macrophages into the dorsal root ganglia were assessed.The intravenous transfer of iTH+ cells before AIA induction did not cause a sustained suppression of AIA severity but significantly reduced inflammation-evoked pain-related behavior. The iTH+ cells used for transfer exhibited enormous production of interleukin-4. A major difference between AIA control mice and iTH+-treated AIA mice was a massive invasion of the dorsal root ganglia by iNOS-negative, arginine 1-positive macrophages corresponding to an M2 phenotype. The differences in other cellular and humoral immune parameters such as release of cytokines from stimulated lymphocytes between AIA control mice and iTH+-treated mice were small.The transfer of iTH+ cells may cause a long-lasting reduction of arthritis-induced pain even if it does not ameliorate inflammation. The invasion of M2 macrophages into the dorsal root ganglia is likely to be an important mechanism of antinociception." @default.
• W2904178552 created "2018-12-22" @default.
• W2904178552 creator A5011116789 @default.
• W2904178552 creator A5032141784 @default.
• W2904178552 creator A5044435374 @default.
• W2904178552 creator A5054509693 @default.
• W2904178552 creator A5066005094 @default.
• W2904178552 creator A5071429887 @default.
• W2904178552 creator A5076613663 @default.
• W2904178552 date "2018-01-01" @default.
• W2904178552 modified "2023-09-26" @default.
• W2904178552 title "A Promising New Approach for the Treatment of Inflammatory Pain: Transfer of Stem Cell-Derived Tyrosine Hydroxylase-Positive Cells" @default.
• W2904178552 cites W1504658605 @default.
• W2904178552 cites W1558334237 @default.
• W2904178552 cites W1615447620 @default.
• W2904178552 cites W1931778400 @default.
• W2904178552 cites W1941510651 @default.
• W2904178552 cites W1963642761 @default.
• W2904178552 cites W1964953009 @default.
• W2904178552 cites W1977014779 @default.
• W2904178552 cites W1982530999 @default.
• W2904178552 cites W199266805 @default.
• W2904178552 cites W2008732303 @default.
• W2904178552 cites W2016630805 @default.
• W2904178552 cites W2016950635 @default.
• W2904178552 cites W2019400608 @default.
• W2904178552 cites W2020744745 @default.
• W2904178552 cites W2033176002 @default.
• W2904178552 cites W2048732930 @default.
• W2904178552 cites W2053140625 @default.
• W2904178552 cites W2054586855 @default.
• W2904178552 cites W2067954401 @default.
• W2904178552 cites W2068606612 @default.
• W2904178552 cites W2075354833 @default.
• W2904178552 cites W2076274573 @default.
• W2904178552 cites W2079658677 @default.
• W2904178552 cites W2087434676 @default.
• W2904178552 cites W2124514436 @default.
• W2904178552 cites W2135946292 @default.
• W2904178552 cites W2136368099 @default.
• W2904178552 cites W2148405500 @default.
• W2904178552 cites W2152869926 @default.
• W2904178552 cites W2155382840 @default.
• W2904178552 cites W2159182678 @default.
• W2904178552 cites W2167138328 @default.
• W2904178552 cites W2192493004 @default.
• W2904178552 cites W2270670296 @default.
• W2904178552 cites W2528913980 @default.
• W2904178552 cites W2552930080 @default.
• W2904178552 cites W2605144641 @default.
• W2904178552 cites W2605827566 @default.
• W2904178552 cites W2788378244 @default.
• W2904178552 cites W2809445249 @default.
• W2904178552 doi "https://doi.org/10.1159/000495349" @default.
• W2904178552 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30566959" @default.
• W2904178552 hasPublicationYear "2018" @default.
• W2904178552 type Work @default.
• W2904178552 sameAs 2904178552 @default.
• W2904178552 citedByCount "1" @default.
• W2904178552 countsByYear W29041785522022 @default.
• W2904178552 crossrefType "journal-article" @default.
• W2904178552 hasAuthorship W2904178552A5011116789 @default.
• W2904178552 hasAuthorship W2904178552A5032141784 @default.
• W2904178552 hasAuthorship W2904178552A5044435374 @default.
• W2904178552 hasAuthorship W2904178552A5054509693 @default.
• W2904178552 hasAuthorship W2904178552A5066005094 @default.
• W2904178552 hasAuthorship W2904178552A5071429887 @default.
• W2904178552 hasAuthorship W2904178552A5076613663 @default.
• W2904178552 hasConcept C126322002 @default.
• W2904178552 hasConcept C134018914 @default.
• W2904178552 hasConcept C159167319 @default.
• W2904178552 hasConcept C203014093 @default.
• W2904178552 hasConcept C204232928 @default.
• W2904178552 hasConcept C2776914184 @default.
• W2904178552 hasConcept C2777077863 @default.
• W2904178552 hasConcept C2780007613 @default.
• W2904178552 hasConcept C28328180 @default.
• W2904178552 hasConcept C71924100 @default.
• W2904178552 hasConcept C86803240 @default.
• W2904178552 hasConcept C8891405 @default.
• W2904178552 hasConcept C95444343 @default.
• W2904178552 hasConceptScore W2904178552C126322002 @default.
• W2904178552 hasConceptScore W2904178552C134018914 @default.
• W2904178552 hasConceptScore W2904178552C159167319 @default.
• W2904178552 hasConceptScore W2904178552C203014093 @default.
• W2904178552 hasConceptScore W2904178552C204232928 @default.
• W2904178552 hasConceptScore W2904178552C2776914184 @default.
• W2904178552 hasConceptScore W2904178552C2777077863 @default.
• W2904178552 hasConceptScore W2904178552C2780007613 @default.
• W2904178552 hasConceptScore W2904178552C28328180 @default.
• W2904178552 hasConceptScore W2904178552C71924100 @default.
• W2904178552 hasConceptScore W2904178552C86803240 @default.
• W2904178552 hasConceptScore W2904178552C8891405 @default.
• W2904178552 hasConceptScore W2904178552C95444343 @default.
• W2904178552 hasLocation W29041785521 @default.
• W2904178552 hasLocation W29041785522 @default.
• W2904178552 hasOpenAccess W2904178552 @default.
• W2904178552 hasPrimaryLocation W29041785521 @default.
• W2904178552 hasRelatedWork W1592770056 @default.
• W2904178552 hasRelatedWork W1977203467 @default.

• next