Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904178639> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2904178639 abstract "Hypericum perforatum is used as medicinal plant for mild to moderately severe depression. Several trials have found hypericum to be more effective than placebo or some antidepressant drugs, but the exact mechanism and most relevant compounds are still unclear. A possible hypothesis is that the antidepressant activity might be due to its multiplicity of bioactive compounds. Aim is to test if greater chemical complexity could result in a greater hypericum antidepressant action.A retrospective, 12-month, open-label, observational, controlled trial was conducted to compare the antidepressant clinical activity of a conventional Hypericum perforatum (C-Hp) versus a multi-fractionated (M-Hp) one (IperiPlex®).Treatment with C-Hp demonstrated no efficacy after 6 months and partial (P<0.05) efficacy after 12 months. Treatment with MF-Hp demonstrated highly (P<0.01) significant results at both 6 and 12 months. Analysis of the monthly reduction coefficient demonstrated that treatment with MF-Hp was twice as effective as treatment with C-Hp (0.96 versus 0.48). No side effects were reported.A multi-fractionated hypericum extract has better clinical outcomes in subjects with depression without determining an increased risk of toxicity or reduced tolerability." @default.
- W2904178639 created "2018-12-22" @default.
- W2904178639 creator A5027594976 @default.
- W2904178639 creator A5072480911 @default.
- W2904178639 creator A5080872287 @default.
- W2904178639 date "2018-12-01" @default.
- W2904178639 modified "2023-09-26" @default.
- W2904178639 title "Role in depression of a multi-fractionated versus a conventional Hypericum perforatum extract" @default.
- W2904178639 cites W128900338 @default.
- W2904178639 cites W1913372371 @default.
- W2904178639 cites W1966992385 @default.
- W2904178639 cites W1978871608 @default.
- W2904178639 cites W2004270114 @default.
- W2904178639 cites W2019500797 @default.
- W2904178639 cites W2027923042 @default.
- W2904178639 cites W2043116958 @default.
- W2904178639 cites W2043563630 @default.
- W2904178639 cites W2047360221 @default.
- W2904178639 cites W2066174630 @default.
- W2904178639 cites W2070973749 @default.
- W2904178639 cites W2095225769 @default.
- W2904178639 cites W2112712523 @default.
- W2904178639 cites W2135446105 @default.
- W2904178639 cites W2142244531 @default.
- W2904178639 cites W2170701421 @default.
- W2904178639 cites W2436252474 @default.
- W2904178639 cites W3024598542 @default.
- W2904178639 doi "https://doi.org/10.23736/s0031-0808.18.03518-8" @default.
- W2904178639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29991209" @default.
- W2904178639 hasPublicationYear "2018" @default.
- W2904178639 type Work @default.
- W2904178639 sameAs 2904178639 @default.
- W2904178639 citedByCount "12" @default.
- W2904178639 countsByYear W29041786392020 @default.
- W2904178639 countsByYear W29041786392021 @default.
- W2904178639 countsByYear W29041786392022 @default.
- W2904178639 countsByYear W29041786392023 @default.
- W2904178639 crossrefType "journal-article" @default.
- W2904178639 hasAuthorship W2904178639A5027594976 @default.
- W2904178639 hasAuthorship W2904178639A5072480911 @default.
- W2904178639 hasAuthorship W2904178639A5080872287 @default.
- W2904178639 hasConcept C126322002 @default.
- W2904178639 hasConcept C139719470 @default.
- W2904178639 hasConcept C142724271 @default.
- W2904178639 hasConcept C162324750 @default.
- W2904178639 hasConcept C197934379 @default.
- W2904178639 hasConcept C204787440 @default.
- W2904178639 hasConcept C23131810 @default.
- W2904178639 hasConcept C27081682 @default.
- W2904178639 hasConcept C2776651039 @default.
- W2904178639 hasConcept C2776867660 @default.
- W2904178639 hasConcept C2778215561 @default.
- W2904178639 hasConcept C2778375690 @default.
- W2904178639 hasConcept C2779177272 @default.
- W2904178639 hasConcept C2779969877 @default.
- W2904178639 hasConcept C2781161787 @default.
- W2904178639 hasConcept C556039675 @default.
- W2904178639 hasConcept C71924100 @default.
- W2904178639 hasConcept C98274493 @default.
- W2904178639 hasConceptScore W2904178639C126322002 @default.
- W2904178639 hasConceptScore W2904178639C139719470 @default.
- W2904178639 hasConceptScore W2904178639C142724271 @default.
- W2904178639 hasConceptScore W2904178639C162324750 @default.
- W2904178639 hasConceptScore W2904178639C197934379 @default.
- W2904178639 hasConceptScore W2904178639C204787440 @default.
- W2904178639 hasConceptScore W2904178639C23131810 @default.
- W2904178639 hasConceptScore W2904178639C27081682 @default.
- W2904178639 hasConceptScore W2904178639C2776651039 @default.
- W2904178639 hasConceptScore W2904178639C2776867660 @default.
- W2904178639 hasConceptScore W2904178639C2778215561 @default.
- W2904178639 hasConceptScore W2904178639C2778375690 @default.
- W2904178639 hasConceptScore W2904178639C2779177272 @default.
- W2904178639 hasConceptScore W2904178639C2779969877 @default.
- W2904178639 hasConceptScore W2904178639C2781161787 @default.
- W2904178639 hasConceptScore W2904178639C556039675 @default.
- W2904178639 hasConceptScore W2904178639C71924100 @default.
- W2904178639 hasConceptScore W2904178639C98274493 @default.
- W2904178639 hasIssue "4" @default.
- W2904178639 hasLocation W29041786391 @default.
- W2904178639 hasLocation W29041786392 @default.
- W2904178639 hasOpenAccess W2904178639 @default.
- W2904178639 hasPrimaryLocation W29041786391 @default.
- W2904178639 hasRelatedWork W1522052695 @default.
- W2904178639 hasRelatedWork W198870645 @default.
- W2904178639 hasRelatedWork W2000904856 @default.
- W2904178639 hasRelatedWork W2059029852 @default.
- W2904178639 hasRelatedWork W2062551448 @default.
- W2904178639 hasRelatedWork W2072611681 @default.
- W2904178639 hasRelatedWork W2094102744 @default.
- W2904178639 hasRelatedWork W2297247376 @default.
- W2904178639 hasRelatedWork W2904178639 @default.
- W2904178639 hasRelatedWork W3024598542 @default.
- W2904178639 hasVolume "60" @default.
- W2904178639 isParatext "false" @default.
- W2904178639 isRetracted "false" @default.
- W2904178639 magId "2904178639" @default.
- W2904178639 workType "article" @default.