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- W2904182022 abstract "INTRODUCTION:Ascites is a Greek derivative (askos) and it refers to bag or sack. Ascites is pathologic fluid accumulation within the peritoneal cavity. The most common cause of ascites is cirrhosis with portal hypertension (85%) which occurs within 10years of diagnosing cirrhosis. Ascites is due to many factors like diseases involving peritoneum (peritonitis, malignancy), liver disease, cardiac failure, hypoproteinemia. In Western countries, cirrhosis is the most common cause of ascites(76%), followed by peritoneal malignancy (14%), cardiac failure (5%), peritoneal tuberculosis (4%). The development of ascites in cirrhotic patients denotes that the patient progressed to decompensated cirrhosis. There are many complications of cirrhosis like portal hypertension, hepatic encephalopathy, hepatorenal syndrome of which the development of portal hypertension and its manifestation ascites is common and is gaining more importance. AIM OF THE STUDY:Ascitic fluid infection primarily consists of two variants- Spontaneous Bacterial peritonitis and culture negative neutrocytic ascites. Mean platelet volume (MPV) is used as a cheap and non invasive indicator of inflammation in various systemic conditions. So our aim is to analyse whether platelet size alteration would be used as an indicator of ascetic fluid infection in cirrhotic patients. MATERIALS AND METHODS:A total of 75 patients with ascites with cirrhosis were enrolled in this study. According to ascitic fluid analysis, 29 patients were diagnosed to have ascetic fluid infection. CBC including MPV, ESR were determined for all participants. The ability of MPV in determining ascetic fluid infections were analysed using Pearson chi- square and Fisher extract test. RESULTS: A statistically significant increase in MPV was observed in cirrhotic patients with AFI compared to cirrhotic patients without AFI (P<0.005). A statistically significant observation was observed in respect to MPV, ESR, TC, Ascitic fluid PMN count and culture. CONCLUSION: Our study shows that MPV is increased in cirrhotic patients with AFI. MPV measurement can be considered as an accurate diagnostic test in predicting AFI, possibly due to ongoing systemic inflammatory response." @default.
- W2904182022 created "2018-12-22" @default.
- W2904182022 creator A5058659398 @default.
- W2904182022 date "2015-04-01" @default.
- W2904182022 modified "2023-09-26" @default.
- W2904182022 title "Mean Platelet Volume an Indicator of Ascitic Fluid Infections in Cirrhotic Patients" @default.
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