FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904184497> ?p ?o ?g. }

• W2904184497 endingPage "1490" @default.
• W2904184497 startingPage "1485" @default.
• W2904184497 abstract "Objectives: A proportion of HIV-infected children with advanced disease develop severe malnutrition soon after antiretroviral therapy (ART) initiation. We tested the hypothesis that systemic inflammation underlies the pathogenesis of severe malnutrition in HIV-infected children. Design: Cross-sectional laboratory substudy in 613 HIV-infected children initiating ART in Uganda and Zimbabwe. Methods: We measured C-reactive protein (CRP), TNFα, IL-6 and soluble CD14 by ELISA in cryopreserved plasma at baseline (pre-ART) and week-4 (children with severe malnutrition only). Independent associations between baseline biomarkers and subsequent hospitalization for severe malnutrition were identified using multivariable fractional polynomial logistic regression. Results: Compared with children without severe malnutrition (n = 574, median age 6.3 years, median baseline weight-for-age Z-score −2.2), children hospitalized for severe malnutrition post-ART (n = 39, median age 2.3 years, median baseline weight-for-age Z-score −4.8) had higher baseline CRP [median 13.5 (interquartile range 5.5, 41.1) versus 4.1 (1.4, 14.4) mg/l; P = 0.003] and IL-6 [median 9.2 (6.7, 15.6) versus 5.9 (4.6, 9.3) pg/ml; P < 0.0001], but similar overall TNFα, soluble CD14 and HIV viral load (all P > 0.06). In a multivariable model, higher pre-ART IL-6, lower TNFα and lower weight-for-age were independently associated with subsequent hospitalization for severe malnutrition. Between weeks 0 and 4, there was a significant rise in CRP, IL-6 and soluble CD14, and fall in TNFα and HIV viral load in children hospitalized for severe malnutrition (all P < 0.02). Conclusion: Pre-ART IL-6 and TNFα were more strongly associated with hospitalization for severe malnutrition than CD4+ cell count or viral load, highlighting the importance of inflammation at the time of ART initiation in HIV-infected children." @default.
• W2904184497 created "2018-12-22" @default.
• W2904184497 creator A5003520548 @default.
• W2904184497 creator A5005617480 @default.
• W2904184497 creator A5006114405 @default.
• W2904184497 creator A5006172732 @default.
• W2904184497 creator A5006472610 @default.
• W2904184497 creator A5015650116 @default.
• W2904184497 creator A5030021239 @default.
• W2904184497 creator A5034833817 @default.
• W2904184497 creator A5041072379 @default.
• W2904184497 creator A5043723375 @default.
• W2904184497 creator A5044933203 @default.
• W2904184497 creator A5074802254 @default.
• W2904184497 creator A5078425345 @default.
• W2904184497 creator A5087129711 @default.
• W2904184497 date "2019-07-15" @default.
• W2904184497 modified "2023-09-27" @default.
• W2904184497 title "Inflammatory biomarkers in HIV-infected children hospitalized for severe malnutrition in Uganda and Zimbabwe" @default.
• W2904184497 cites W1979517335 @default.
• W2904184497 cites W1981969796 @default.
• W2904184497 cites W1987150557 @default.
• W2904184497 cites W2011290533 @default.
• W2904184497 cites W2013400967 @default.
• W2904184497 cites W2023895786 @default.
• W2904184497 cites W2040219035 @default.
• W2904184497 cites W2048237871 @default.
• W2904184497 cites W2051865146 @default.
• W2904184497 cites W2072925299 @default.
• W2904184497 cites W2073763357 @default.
• W2904184497 cites W2099750225 @default.
• W2904184497 cites W2110278919 @default.
• W2904184497 cites W2111932307 @default.
• W2904184497 cites W2122544370 @default.
• W2904184497 cites W2142965463 @default.
• W2904184497 cites W2147428192 @default.
• W2904184497 cites W2147884457 @default.
• W2904184497 cites W2167840994 @default.
• W2904184497 cites W2172466148 @default.
• W2904184497 cites W2287923297 @default.
• W2904184497 cites W2300822801 @default.
• W2904184497 cites W2402821985 @default.
• W2904184497 cites W2480739584 @default.
• W2904184497 cites W2520562691 @default.
• W2904184497 cites W2561331421 @default.
• W2904184497 cites W4237493883 @default.
• W2904184497 cites W4252989639 @default.
• W2904184497 doi "https://doi.org/10.1097/qad.0000000000002231" @default.
• W2904184497 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31008797" @default.
• W2904184497 hasPublicationYear "2019" @default.
• W2904184497 type Work @default.
• W2904184497 sameAs 2904184497 @default.
• W2904184497 citedByCount "3" @default.
• W2904184497 countsByYear W29041844972019 @default.
• W2904184497 countsByYear W29041844972022 @default.
• W2904184497 crossrefType "journal-article" @default.
• W2904184497 hasAuthorship W2904184497A5003520548 @default.
• W2904184497 hasAuthorship W2904184497A5005617480 @default.
• W2904184497 hasAuthorship W2904184497A5006114405 @default.
• W2904184497 hasAuthorship W2904184497A5006172732 @default.
• W2904184497 hasAuthorship W2904184497A5006472610 @default.
• W2904184497 hasAuthorship W2904184497A5015650116 @default.
• W2904184497 hasAuthorship W2904184497A5030021239 @default.
• W2904184497 hasAuthorship W2904184497A5034833817 @default.
• W2904184497 hasAuthorship W2904184497A5041072379 @default.
• W2904184497 hasAuthorship W2904184497A5043723375 @default.
• W2904184497 hasAuthorship W2904184497A5044933203 @default.
• W2904184497 hasAuthorship W2904184497A5074802254 @default.
• W2904184497 hasAuthorship W2904184497A5078425345 @default.
• W2904184497 hasAuthorship W2904184497A5087129711 @default.
• W2904184497 hasBestOaLocation W29041844971 @default.
• W2904184497 hasConcept C119060515 @default.
• W2904184497 hasConcept C126322002 @default.
• W2904184497 hasConcept C142462285 @default.
• W2904184497 hasConcept C187212893 @default.
• W2904184497 hasConcept C203014093 @default.
• W2904184497 hasConcept C3013748606 @default.
• W2904184497 hasConcept C551997983 @default.
• W2904184497 hasConcept C71924100 @default.
• W2904184497 hasConcept C90924648 @default.
• W2904184497 hasConceptScore W2904184497C119060515 @default.
• W2904184497 hasConceptScore W2904184497C126322002 @default.
• W2904184497 hasConceptScore W2904184497C142462285 @default.
• W2904184497 hasConceptScore W2904184497C187212893 @default.
• W2904184497 hasConceptScore W2904184497C203014093 @default.
• W2904184497 hasConceptScore W2904184497C3013748606 @default.
• W2904184497 hasConceptScore W2904184497C551997983 @default.
• W2904184497 hasConceptScore W2904184497C71924100 @default.
• W2904184497 hasConceptScore W2904184497C90924648 @default.
• W2904184497 hasIssue "9" @default.
• W2904184497 hasLocation W29041844971 @default.
• W2904184497 hasLocation W29041844972 @default.
• W2904184497 hasLocation W29041844973 @default.
• W2904184497 hasLocation W29041844974 @default.
• W2904184497 hasLocation W29041844975 @default.
• W2904184497 hasLocation W29041844976 @default.
• W2904184497 hasLocation W29041844977 @default.
• W2904184497 hasOpenAccess W2904184497 @default.

• next