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- W2904189062 abstract "In this paper, we deal with the problem of tracking a desired plasma glucose concentration by means of intravenous insulin administration, for Type 2 diabetic patients. A nonlinear time-delay model is used to describe the glucose-insulin regulatory system, according to which a model-based approach is exploited to design a semiglobal sampled-data dynamic output feedback controller. It is shown that emulation, by Euler approximation, of a proposed continuous-time control law yields stabilization in the sample-and-hold sense of the glucose-insulin system. The glucose regulator makes use of only sampled glucose measurements. Theoretical results are preclinically validated through a virtual environment broadly accepted as a substitute to animal trials for the preclinical testing of control strategies in plasma glucose regulation. Numerical results are encouraging and pave the way to further clinical verifications." @default.
- W2904189062 created "2018-12-22" @default.
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- W2904189062 date "2020-01-01" @default.
- W2904189062 modified "2023-10-01" @default.
- W2904189062 title "Semiglobal Sampled-Data Dynamic Output Feedback Controller for the Glucose–Insulin System" @default.
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- W2904189062 doi "https://doi.org/10.1109/tcst.2018.2881662" @default.
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