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- W2904189644 abstract "Abstract Histone modification is a ubiquitous regulatory mechanism involved in a variety of biological processes, including gene expression, DNA damage repair, cell differentiation, and ontogenesis. Succinylation sites on histones have been identified and may have functional consequences. Here, we demonstrate that human sirtuin 5 (Sirt5) catalyzes the sequence-selective desuccinylation of numerous histone succinyl sites. Structural studies of Sirt5 in complex with four succinyl peptides indicate an essential role for the conserved main chain hydrogen bonds formed by the succinyl lysine (0), +1, and +3 sites for substrate-enzyme recognition. Furthermore, biochemical assays reveal that the proline residue at the +1 site of the histone succinylation substrate is unfavorable for Sirt5 interaction. Our findings illustrate the molecular mechanism underlying the sequence-selective desuccinylase activity of Sirt5 and provide insights for further studies of the biological functions associated with histone succinylation and Sirt5." @default.
- W2904189644 created "2018-12-22" @default.
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- W2904189644 date "2019-01-18" @default.
- W2904189644 modified "2023-10-18" @default.
- W2904189644 title "Structural insights into the molecular mechanism underlying Sirt5-catalyzed desuccinylation of histone peptides" @default.
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- W2904189644 doi "https://doi.org/10.1042/bcj20180745" @default.
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