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• W2904192607 abstract "Variability of neural signaling is an important index of healthy brain functioning, as is signal complexity, which relates to information processing capacity. Alterations in variability and complexity may underlie certain brain dysfunctions. Here, resting-state fMRI was used to examine variability and complexity in children and adolescents with and without autism spectrum disorder (ASD). Variability was measured using the mean square successive difference (MSSD) of the time series, and complexity was assessed using sample entropy. A categorical approach was implemented to determine if the brain measures differed between diagnostic groups (ASD and controls). A dimensional approach was used to examine the continuum of relationships between each brain measure and behavioral severity, age, IQ, and the global efficiency (GE) of each participant's structural connectome, which reflects the structural capacity for information processing. Using the categorical approach, no significant group differences were found for neither MSSD nor entropy. The dimensional approach revealed significant positive correlations between each brain measure, GE, and age. Negative correlations were observed between each brain measure and the severity of ASD behaviors across all participants. These results reveal the nature of variability and complexity of BOLD signals in children and adolescents with and without ASD." @default.
• W2904192607 created "2018-12-22" @default.
• W2904192607 creator A5082140812 @default.
• W2904192607 creator A5088602493 @default.
• W2904192607 date "2019-04-01" @default.
• W2904192607 modified "2023-10-16" @default.
• W2904192607 title "BOLD signal variability and complexity in children and adolescents with and without autism spectrum disorder" @default.
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• W2904192607 doi "https://doi.org/10.1016/j.dcn.2019.100630" @default.
• W2904192607 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6969202" @default.
• W2904192607 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30878549" @default.
• W2904192607 hasPublicationYear "2019" @default.
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