FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904195324> ?p ?o ?g. }

• W2904195324 endingPage "4094" @default.
• W2904195324 startingPage "4094" @default.
• W2904195324 abstract "Lipid expression is increased in the atrial myocytes of mitral regurgitation (MR) patients. This study aimed to investigate key regulatory genes and mechanisms of atrial lipotoxic myopathy in MR.The HL-1 atrial myocytes were subjected to uniaxial cyclic stretching for eight hours. Fatty acid metabolism, lipoprotein signaling, and cholesterol metabolism were analyzed by PCR assay (168 genes).The stretched myocytes had significantly larger cell size and higher lipid expression than non-stretched myocytes (all p < 0.001). Fatty acid metabolism, lipoprotein signaling, and cholesterol metabolism in the myocytes were analyzed by PCR assay (168 genes). In comparison with their counterparts in non-stretched myocytes, seven genes in stretched monocytes (Idi1, Olr1, Nr1h4, Fabp2, Prkag3, Slc27a5, Fabp6) revealed differential upregulation with an altered fold change >1.5. Nine genes in stretched monocytes (Apoa4, Hmgcs2, Apol8, Srebf1, Acsm4, Fabp1, Acox2, Acsl6, Gk) revealed differential downregulation with an altered fold change <0.67. Canonical pathway analysis, using Ingenuity Pathway Analysis software, revealed that the only genes in the superpathway of cholesterol biosynthesis were Idi1 (upregulated) and Hmgcs2 (downregulated). The fraction of stretched myocytes expressing Nile red was significantly decreased by RNA interference of Idi1 (p < 0.05) and was significantly decreased by plasmid transfection of Hmgcs2 (p = 0.004).The Idi1 and Hmgcs2 genes have regulatory roles in atrial lipotoxic myopathy associated with atrial enlargement." @default.
• W2904195324 created "2018-12-22" @default.
• W2904195324 creator A5008095508 @default.
• W2904195324 creator A5008637858 @default.
• W2904195324 creator A5014564819 @default.
• W2904195324 creator A5031594610 @default.
• W2904195324 creator A5041773078 @default.
• W2904195324 creator A5051950685 @default.
• W2904195324 creator A5054721431 @default.
• W2904195324 creator A5055103555 @default.
• W2904195324 creator A5058784586 @default.
• W2904195324 creator A5065641887 @default.
• W2904195324 creator A5080484114 @default.
• W2904195324 creator A5090431373 @default.
• W2904195324 creator A5091078255 @default.
• W2904195324 date "2018-12-18" @default.
• W2904195324 modified "2023-09-27" @default.
• W2904195324 title "Idi1 and Hmgcs2 Are Affected by Stretch in HL-1 Atrial Myocytes" @default.
• W2904195324 cites W1969825423 @default.
• W2904195324 cites W1971439334 @default.
• W2904195324 cites W1994895399 @default.
• W2904195324 cites W1995321764 @default.
• W2904195324 cites W2002941215 @default.
• W2904195324 cites W2003419452 @default.
• W2904195324 cites W2005999729 @default.
• W2904195324 cites W2019892938 @default.
• W2904195324 cites W2022143285 @default.
• W2904195324 cites W2051027491 @default.
• W2904195324 cites W2078883339 @default.
• W2904195324 cites W2106136854 @default.
• W2904195324 cites W2113328569 @default.
• W2904195324 cites W2115155477 @default.
• W2904195324 cites W2117820310 @default.
• W2904195324 cites W2139002144 @default.
• W2904195324 cites W2141314779 @default.
• W2904195324 cites W2159697997 @default.
• W2904195324 cites W2169041822 @default.
• W2904195324 cites W2171332415 @default.
• W2904195324 cites W231815598 @default.
• W2904195324 cites W2416216282 @default.
• W2904195324 cites W2509795914 @default.
• W2904195324 cites W2664551728 @default.
• W2904195324 cites W3004050106 @default.
• W2904195324 cites W3023891555 @default.
• W2904195324 cites W4211189349 @default.
• W2904195324 cites W4233372927 @default.
• W2904195324 doi "https://doi.org/10.3390/ijms19124094" @default.
• W2904195324 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6321625" @default.
• W2904195324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30567295" @default.
• W2904195324 hasPublicationYear "2018" @default.
• W2904195324 type Work @default.
• W2904195324 sameAs 2904195324 @default.
• W2904195324 citedByCount "4" @default.
• W2904195324 countsByYear W29041953242020 @default.
• W2904195324 countsByYear W29041953242021 @default.
• W2904195324 countsByYear W29041953242022 @default.
• W2904195324 crossrefType "journal-article" @default.
• W2904195324 hasAuthorship W2904195324A5008095508 @default.
• W2904195324 hasAuthorship W2904195324A5008637858 @default.
• W2904195324 hasAuthorship W2904195324A5014564819 @default.
• W2904195324 hasAuthorship W2904195324A5031594610 @default.
• W2904195324 hasAuthorship W2904195324A5041773078 @default.
• W2904195324 hasAuthorship W2904195324A5051950685 @default.
• W2904195324 hasAuthorship W2904195324A5054721431 @default.
• W2904195324 hasAuthorship W2904195324A5055103555 @default.
• W2904195324 hasAuthorship W2904195324A5058784586 @default.
• W2904195324 hasAuthorship W2904195324A5065641887 @default.
• W2904195324 hasAuthorship W2904195324A5080484114 @default.
• W2904195324 hasAuthorship W2904195324A5090431373 @default.
• W2904195324 hasAuthorship W2904195324A5091078255 @default.
• W2904195324 hasBestOaLocation W29041953241 @default.
• W2904195324 hasConcept C104317684 @default.
• W2904195324 hasConcept C126322002 @default.
• W2904195324 hasConcept C127561419 @default.
• W2904195324 hasConcept C134018914 @default.
• W2904195324 hasConcept C185592680 @default.
• W2904195324 hasConcept C207200792 @default.
• W2904195324 hasConcept C2776991927 @default.
• W2904195324 hasConcept C3763915 @default.
• W2904195324 hasConcept C4733338 @default.
• W2904195324 hasConcept C55493867 @default.
• W2904195324 hasConcept C62231903 @default.
• W2904195324 hasConcept C71924100 @default.
• W2904195324 hasConcept C86803240 @default.
• W2904195324 hasConcept C95444343 @default.
• W2904195324 hasConceptScore W2904195324C104317684 @default.
• W2904195324 hasConceptScore W2904195324C126322002 @default.
• W2904195324 hasConceptScore W2904195324C127561419 @default.
• W2904195324 hasConceptScore W2904195324C134018914 @default.
• W2904195324 hasConceptScore W2904195324C185592680 @default.
• W2904195324 hasConceptScore W2904195324C207200792 @default.
• W2904195324 hasConceptScore W2904195324C2776991927 @default.
• W2904195324 hasConceptScore W2904195324C3763915 @default.
• W2904195324 hasConceptScore W2904195324C4733338 @default.
• W2904195324 hasConceptScore W2904195324C55493867 @default.
• W2904195324 hasConceptScore W2904195324C62231903 @default.
• W2904195324 hasConceptScore W2904195324C71924100 @default.
• W2904195324 hasConceptScore W2904195324C86803240 @default.

• next