FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904197888> ?p ?o ?g. }

• W2904197888 endingPage "204" @default.
• W2904197888 startingPage "199" @default.
• W2904197888 abstract "Access to safe and effective contraceptive choices is a reproductive right and contributes tremendously to improvements in maternal and child health. Progestin-only injectables, particularly intramuscularly injected depot medroxyprogesterone acetate (DMPA-IM), have received increased attention given findings suggesting a potential association with increased HIV risk. For women at high risk of HIV, the World Health Organization's Medical eligibility criteria for contraceptive use currently aggregate recommendations for all progestin-only injectables, including DMPA-IM, subcutaneously injected DMPA (DMPA-SC) and intramuscularly injected norethindrone/ norethisterone enanthate (NET-EN), except in the case of some drug interactions. We considered whether published data indicate differences or similarities between these injectables relevant to risk of acquiring HIV. In vitro data confirm different biological activities of these distinct progestins, including that MPA, and not NET, binds and activates the glucocorticoid receptor resulting in different biological effects relevant to immune function. Limited clinical data suggest changes in immunologic activity following DMPA-IM and NET-EN initiation, but interstudy variation and study design differences diminish ability to determine clinical relevance and the degree to which DMPA-IM and NET-EN could act differentially. The highest-quality epidemiologic studies suggest a potential 40% increase in HIV incidence in users of DMPA-IM relative to women not using hormonal contraception but no significant increase in risk in users of NET-EN. In our opinion, most of the available biologic activity and epidemiologic data indicate that DMPA and NET-EN are likely to act differently, and data remain too limited to evaluate differences between DMPA-IM and DMPA-SC." @default.
• W2904197888 created "2018-12-22" @default.
• W2904197888 creator A5012456772 @default.
• W2904197888 creator A5025100815 @default.
• W2904197888 creator A5025893306 @default.
• W2904197888 creator A5058466834 @default.
• W2904197888 creator A5062258141 @default.
• W2904197888 creator A5077253980 @default.
• W2904197888 creator A5090085349 @default.
• W2904197888 date "2019-04-01" @default.
• W2904197888 modified "2023-09-25" @default.
• W2904197888 title "Pharmacokinetic, biologic and epidemiologic differences in MPA- and NET-based progestin-only injectable contraceptives relative to the potential impact on HIV acquisition in women" @default.
• W2904197888 cites W1505580575 @default.
• W2904197888 cites W1556899384 @default.
• W2904197888 cites W1593235060 @default.
• W2904197888 cites W1708218669 @default.
• W2904197888 cites W1910585352 @default.
• W2904197888 cites W1963960283 @default.
• W2904197888 cites W1965203729 @default.
• W2904197888 cites W1967198637 @default.
• W2904197888 cites W1988373865 @default.
• W2904197888 cites W1994969160 @default.
• W2904197888 cites W2000328498 @default.
• W2904197888 cites W2006584323 @default.
• W2904197888 cites W2006875003 @default.
• W2904197888 cites W2009856015 @default.
• W2904197888 cites W2010681593 @default.
• W2904197888 cites W2019325726 @default.
• W2904197888 cites W2020447653 @default.
• W2904197888 cites W2022967210 @default.
• W2904197888 cites W2024230321 @default.
• W2904197888 cites W2029754962 @default.
• W2904197888 cites W2030555662 @default.
• W2904197888 cites W2047798559 @default.
• W2904197888 cites W2048062672 @default.
• W2904197888 cites W2052297954 @default.
• W2904197888 cites W2053676070 @default.
• W2904197888 cites W2054703956 @default.
• W2904197888 cites W2057880386 @default.
• W2904197888 cites W2061082300 @default.
• W2904197888 cites W2062207606 @default.
• W2904197888 cites W2065379430 @default.
• W2904197888 cites W2067287778 @default.
• W2904197888 cites W2075276906 @default.
• W2904197888 cites W2076003723 @default.
• W2904197888 cites W2076720074 @default.
• W2904197888 cites W2085756712 @default.
• W2904197888 cites W2090456077 @default.
• W2904197888 cites W2092040785 @default.
• W2904197888 cites W2103846516 @default.
• W2904197888 cites W2110377641 @default.
• W2904197888 cites W2112529118 @default.
• W2904197888 cites W2116728300 @default.
• W2904197888 cites W2119224995 @default.
• W2904197888 cites W2121397997 @default.
• W2904197888 cites W2128538962 @default.
• W2904197888 cites W2131545113 @default.
• W2904197888 cites W2131638691 @default.
• W2904197888 cites W2135463798 @default.
• W2904197888 cites W2136934371 @default.
• W2904197888 cites W2142170543 @default.
• W2904197888 cites W2142599245 @default.
• W2904197888 cites W2143586891 @default.
• W2904197888 cites W2152637803 @default.
• W2904197888 cites W2163962414 @default.
• W2904197888 cites W2165782596 @default.
• W2904197888 cites W2165823914 @default.
• W2904197888 cites W2168588656 @default.
• W2904197888 cites W2216450681 @default.
• W2904197888 cites W2266163257 @default.
• W2904197888 cites W2301732924 @default.
• W2904197888 cites W2311480849 @default.
• W2904197888 cites W2519243539 @default.
• W2904197888 cites W2544080039 @default.
• W2904197888 cites W2558107505 @default.
• W2904197888 cites W2766612280 @default.
• W2904197888 cites W2769858950 @default.
• W2904197888 cites W2775425385 @default.
• W2904197888 cites W2778573628 @default.
• W2904197888 cites W2782051442 @default.
• W2904197888 cites W2784439478 @default.
• W2904197888 cites W2786377683 @default.
• W2904197888 cites W2792298605 @default.
• W2904197888 cites W2792717467 @default.
• W2904197888 cites W2802948552 @default.
• W2904197888 cites W8747624 @default.
• W2904197888 doi "https://doi.org/10.1016/j.contraception.2018.12.001" @default.
• W2904197888 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6467541" @default.
• W2904197888 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30576636" @default.
• W2904197888 hasPublicationYear "2019" @default.
• W2904197888 type Work @default.
• W2904197888 sameAs 2904197888 @default.
• W2904197888 citedByCount "15" @default.
• W2904197888 countsByYear W29041978882019 @default.
• W2904197888 countsByYear W29041978882020 @default.
• W2904197888 countsByYear W29041978882021 @default.
• W2904197888 countsByYear W29041978882022 @default.
• W2904197888 countsByYear W29041978882023 @default.

• next