FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904198539> ?p ?o ?g. }

• W2904198539 endingPage "10" @default.
• W2904198539 startingPage "1" @default.
• W2904198539 abstract "Activating transcription factor 4 (ATF4) is induced by various stressors. Here, we investigated the expression of ATF4 in the host inflammatory response to Aspergillus fumigatus (A. fumigatus) keratitis.A. fumigatus keratitis mouse models developed by intrastromal injection as well as corneal epithelium scratching were examined daily with a slit lamp microscope for corneal opacification and ulceration. Subsequent in vitro experimentation was carried out in human corneal epithelial cells (HCECs) as well as THP-1 macrophages infected with A. fumigatus. Inhibitors, including CLI-095, Poly (I), SCH772984, and SP600125, were used to assess the role of proteins like toll-like receptor 4 (TLR4), lectin-type oxidized LDL receptor 1 (LOX-1), extracellular signal-regulated kinases (ERK1/2), and c-Jun N-terminal kinase (JNK) in ATF4 expression as a response to A. fumigatus infection. This assessment was made in both mouse models and HCECs using western blot.Compared to the controls, ATF4 was increased in corneas from two kinds of A. fumigatus keratitis models at 3 days after infection. ATF4 expression was upregulated with A. fumigatus conidia both in HCECs and THP-1 macrophages 16 hours after stimulation. Furthermore, ATF4 expression in response to A. fumigatus infection was shown to be dependent on TLR4 and LOX-1 expression, and ERK1/2 and JNK contributed to the expression of ATF4 in response to A. fumigatus.Our results clearly indicate that ATF4 was involved in the host antifungal immune response to A. fumigatus keratitis; expression was found to be dependent on TLR4, LOX-1 expression, and MAPKs pathway." @default.
• W2904198539 created "2018-12-22" @default.
• W2904198539 creator A5007904196 @default.
• W2904198539 creator A5013140672 @default.
• W2904198539 creator A5029917284 @default.
• W2904198539 creator A5034102120 @default.
• W2904198539 creator A5047029286 @default.
• W2904198539 date "2018-12-13" @default.
• W2904198539 modified "2023-10-17" @default.
• W2904198539 title "ATF4 Involvement in TLR4 and LOX-1-Induced Host Inflammatory Response to <i>Aspergillus fumigatus</i> Keratitis" @default.
• W2904198539 cites W1599517549 @default.
• W2904198539 cites W1682808632 @default.
• W2904198539 cites W1964221204 @default.
• W2904198539 cites W1971144696 @default.
• W2904198539 cites W1971268002 @default.
• W2904198539 cites W1983462777 @default.
• W2904198539 cites W2041297702 @default.
• W2904198539 cites W2054877805 @default.
• W2904198539 cites W2074846423 @default.
• W2904198539 cites W2091557210 @default.
• W2904198539 cites W2099580227 @default.
• W2904198539 cites W2104989405 @default.
• W2904198539 cites W2149846968 @default.
• W2904198539 cites W2194700173 @default.
• W2904198539 cites W2214000001 @default.
• W2904198539 cites W2253371766 @default.
• W2904198539 cites W2282557279 @default.
• W2904198539 cites W2294606406 @default.
• W2904198539 cites W2296002651 @default.
• W2904198539 cites W2330933917 @default.
• W2904198539 cites W2333103328 @default.
• W2904198539 cites W2339387363 @default.
• W2904198539 cites W2342000077 @default.
• W2904198539 cites W2342683208 @default.
• W2904198539 cites W2346412210 @default.
• W2904198539 cites W2387073006 @default.
• W2904198539 cites W2406486782 @default.
• W2904198539 cites W2524170467 @default.
• W2904198539 cites W2560817519 @default.
• W2904198539 cites W2589917023 @default.
• W2904198539 cites W2591554718 @default.
• W2904198539 cites W2610851342 @default.
• W2904198539 cites W2611540963 @default.
• W2904198539 cites W2612623795 @default.
• W2904198539 cites W2626163193 @default.
• W2904198539 cites W2695493734 @default.
• W2904198539 cites W2742536940 @default.
• W2904198539 cites W2742908125 @default.
• W2904198539 cites W2753104245 @default.
• W2904198539 cites W2754127693 @default.
• W2904198539 cites W2754633733 @default.
• W2904198539 cites W2757444754 @default.
• W2904198539 cites W2764071129 @default.
• W2904198539 cites W2793608126 @default.
• W2904198539 cites W2795020867 @default.
• W2904198539 cites W2801637338 @default.
• W2904198539 cites W51508990 @default.
• W2904198539 doi "https://doi.org/10.1155/2018/5830202" @default.
• W2904198539 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6311808" @default.
• W2904198539 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30647960" @default.
• W2904198539 hasPublicationYear "2018" @default.
• W2904198539 type Work @default.
• W2904198539 sameAs 2904198539 @default.
• W2904198539 citedByCount "4" @default.
• W2904198539 countsByYear W29041985392020 @default.
• W2904198539 countsByYear W29041985392022 @default.
• W2904198539 crossrefType "journal-article" @default.
• W2904198539 hasAuthorship W2904198539A5007904196 @default.
• W2904198539 hasAuthorship W2904198539A5013140672 @default.
• W2904198539 hasAuthorship W2904198539A5029917284 @default.
• W2904198539 hasAuthorship W2904198539A5034102120 @default.
• W2904198539 hasAuthorship W2904198539A5047029286 @default.
• W2904198539 hasBestOaLocation W29041985391 @default.
• W2904198539 hasConcept C104317684 @default.
• W2904198539 hasConcept C118487528 @default.
• W2904198539 hasConcept C203014093 @default.
• W2904198539 hasConcept C2776070231 @default.
• W2904198539 hasConcept C2776079991 @default.
• W2904198539 hasConcept C2776415932 @default.
• W2904198539 hasConcept C2778560704 @default.
• W2904198539 hasConcept C2779338263 @default.
• W2904198539 hasConcept C2779725641 @default.
• W2904198539 hasConcept C2779787849 @default.
• W2904198539 hasConcept C2780900454 @default.
• W2904198539 hasConcept C55493867 @default.
• W2904198539 hasConcept C71924100 @default.
• W2904198539 hasConcept C86803240 @default.
• W2904198539 hasConcept C8891405 @default.
• W2904198539 hasConcept C89423630 @default.
• W2904198539 hasConceptScore W2904198539C104317684 @default.
• W2904198539 hasConceptScore W2904198539C118487528 @default.
• W2904198539 hasConceptScore W2904198539C203014093 @default.
• W2904198539 hasConceptScore W2904198539C2776070231 @default.
• W2904198539 hasConceptScore W2904198539C2776079991 @default.
• W2904198539 hasConceptScore W2904198539C2776415932 @default.
• W2904198539 hasConceptScore W2904198539C2778560704 @default.
• W2904198539 hasConceptScore W2904198539C2779338263 @default.
• W2904198539 hasConceptScore W2904198539C2779725641 @default.

• next