Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904207909> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2904207909 abstract "Epstein-Barr virus infection is associated with several lymphoid and epithelial malignancies. The replication and persistence of the EBV genome in latently infected cells is dependent on the homodimer formation of EBV nuclear antigen 1 (EBNA1) and it’s binding to the cognate EBV OriP element. Current chemotherapeutic treatments of EBV-positive malignancies are non-specific to the EBV status of the disease. We have designed and synthesised eight small peptides using Solid Phase Peptide Synthesis, aimed to prevent EBNA1 homodimer formation and destabilise existing homodimers. These putative dimer inhibitory peptides (DIP), designed to mimic the proline loop of the protein (which stabilises the dimer) are attached to the cell penetrating peptide TAT, to act as competitive inhibitors in the nucleus of infected cells. Data will be presented on the effect of these peptides on multiple EBV dependent and independent tumour B cell lines, with respect to cell penetration, cell viability and protein dimerisation. These peptides may provide a novel approach to treating EBV positive and dependent disease by inhibiting viral persistence, and possibly the cell survival properties of EBNA1." @default.
- W2904207909 created "2018-12-22" @default.
- W2904207909 creator A5046358376 @default.
- W2904207909 creator A5060532074 @default.
- W2904207909 creator A5062289846 @default.
- W2904207909 date "2016-08-08" @default.
- W2904207909 modified "2023-09-27" @default.
- W2904207909 title "Therapeutic Approaches to Targetting Epstein-Barr Virus Related Disease" @default.
- W2904207909 hasPublicationYear "2016" @default.
- W2904207909 type Work @default.
- W2904207909 sameAs 2904207909 @default.
- W2904207909 citedByCount "0" @default.
- W2904207909 crossrefType "journal-article" @default.
- W2904207909 hasAuthorship W2904207909A5046358376 @default.
- W2904207909 hasAuthorship W2904207909A5060532074 @default.
- W2904207909 hasAuthorship W2904207909A5062289846 @default.
- W2904207909 hasConcept C147483822 @default.
- W2904207909 hasConcept C1491633281 @default.
- W2904207909 hasConcept C159047783 @default.
- W2904207909 hasConcept C182615771 @default.
- W2904207909 hasConcept C203014093 @default.
- W2904207909 hasConcept C2522874641 @default.
- W2904207909 hasConcept C2779281246 @default.
- W2904207909 hasConcept C2781375147 @default.
- W2904207909 hasConcept C502942594 @default.
- W2904207909 hasConcept C54355233 @default.
- W2904207909 hasConcept C55493867 @default.
- W2904207909 hasConcept C81885089 @default.
- W2904207909 hasConcept C86803240 @default.
- W2904207909 hasConceptScore W2904207909C147483822 @default.
- W2904207909 hasConceptScore W2904207909C1491633281 @default.
- W2904207909 hasConceptScore W2904207909C159047783 @default.
- W2904207909 hasConceptScore W2904207909C182615771 @default.
- W2904207909 hasConceptScore W2904207909C203014093 @default.
- W2904207909 hasConceptScore W2904207909C2522874641 @default.
- W2904207909 hasConceptScore W2904207909C2779281246 @default.
- W2904207909 hasConceptScore W2904207909C2781375147 @default.
- W2904207909 hasConceptScore W2904207909C502942594 @default.
- W2904207909 hasConceptScore W2904207909C54355233 @default.
- W2904207909 hasConceptScore W2904207909C55493867 @default.
- W2904207909 hasConceptScore W2904207909C81885089 @default.
- W2904207909 hasConceptScore W2904207909C86803240 @default.
- W2904207909 hasLocation W29042079091 @default.
- W2904207909 hasOpenAccess W2904207909 @default.
- W2904207909 hasPrimaryLocation W29042079091 @default.
- W2904207909 hasRelatedWork W1975216103 @default.
- W2904207909 hasRelatedWork W1986234697 @default.
- W2904207909 hasRelatedWork W2034601852 @default.
- W2904207909 hasRelatedWork W2065704346 @default.
- W2904207909 hasRelatedWork W2094602018 @default.
- W2904207909 hasRelatedWork W2104656080 @default.
- W2904207909 hasRelatedWork W2116284248 @default.
- W2904207909 hasRelatedWork W2147834015 @default.
- W2904207909 hasRelatedWork W2153913666 @default.
- W2904207909 hasRelatedWork W2160823232 @default.
- W2904207909 hasRelatedWork W2597398126 @default.
- W2904207909 hasRelatedWork W2801021823 @default.
- W2904207909 hasRelatedWork W2816428498 @default.
- W2904207909 hasRelatedWork W2905402289 @default.
- W2904207909 hasRelatedWork W2994641803 @default.
- W2904207909 hasRelatedWork W3006297435 @default.
- W2904207909 hasRelatedWork W3133343273 @default.
- W2904207909 hasRelatedWork W3142924810 @default.
- W2904207909 hasRelatedWork W3191813615 @default.
- W2904207909 hasRelatedWork W3203492887 @default.
- W2904207909 isParatext "false" @default.
- W2904207909 isRetracted "false" @default.
- W2904207909 magId "2904207909" @default.
- W2904207909 workType "article" @default.