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• W2904209929 abstract "Effects of paraquat (PQ) on interleukin‑6 (IL‑6) and tumor necrosis factor‑α (TNF‑α) in macrophages were investigated. Different concentrations of PQ were added to mouse macrophage RAW264.7 for culture. According to different concentrations of PQ, mice were divided into micro concentration (0.01 mmol/l), low concentration (0.1 mmol/l), medium concentration (1 mmol/l), high concentration (10 mmol/l), and control groups without PQ. Trypan blue solution was used for detecting cell viability, a microplate reader for detecting the fluorescence intensity of reactive oxygen species (ROS), ELISA for detecting the expression levels of IL‑6 and TNF‑α. The medium concentration and the high concentration groups had significantly lower cell viability than the other three groups (P<0.050). The high concentration group had significantly lower cell viability than the medium concentration group (P<0.050). At 1, 4 and 8 h, respectively, the medium and the high concentration groups had significantly higher ROS fluorescence intensity than the other three groups (P<0.050). The high concentration group had significantly higher ROS fluorescence intensity than the medium concentration group (P<0.050). There were significant differences in the expression levels of IL‑6 and TNF‑α at the 1st, 4th and 8th hour among the five groups (P<0.050). In the micro, the low, the medium and high concentration groups, the expression levels of IL‑6 and TNF‑α were the lowest at 1 h and the highest at 8 h, which were higher at 4 h than those at 1 h (P<0.050). PQ at a concentration of 1 mmol/l can produce toxicity to macrophages, and greatly increase the ROS fluorescence intensity, the expression levels of IL‑6 and TNF‑α. PQ poisoning is expected to be treated though IL‑6 and TNF‑α in the future." @default.
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• W2904209929 date "2018-12-14" @default.
• W2904209929 modified "2023-10-12" @default.
• W2904209929 title "Effects of paraquat on IL‑6 and TNF‑α in macrophages" @default.
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• W2904209929 doi "https://doi.org/10.3892/etm.2018.7099" @default.
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