Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904219651> ?p ?o ?g. }
- W2904219651 abstract "Electrical skin measurements at acupuncture points (acupoints) have been utilized as a diagnostic and therapeutic aid for more than 50 years. Although acupoints are described as having distinct electrical properties, such as high conductance and low impedance, the underlying mechanisms are currently unknown. The present study investigated in a rat model of hypertension whether the high conductance at acupoints is a result of the release of the neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP) during neurogenic inflammation in the referred pain area. When plasma extravasation from neurogenic inflammation was examined by exploring the leakage of intravenously injected Evans blue dye (EBD) to the skin, extravasated EBD was found most frequently in acupoints on the wrist. The increased conductance and temperature at these acupoints occurred during the development of hypertension. The increase in conductance and plasma extravasation at acupoints in hypertensive rats was ablated by cutting median and ulnar nerves, blocking small diameter afferent fibers with resiniferatoxin (RTX) injection into median and ulnar nerves, or antagonizing SP or CGRP receptors in acupoints. In turn, intradermal injection of SP or CGRP resulted in increased conductance and plasma extravasation in naïve rats. Elevated levels of SP and CGRP were found in the acupoints of hypertensive rats. These findings suggest that the high conductance at acupoints is due to vascular leakage following local release of SP and CGRP during neurogenic inflammation." @default.
- W2904219651 created "2018-12-22" @default.
- W2904219651 creator A5005652887 @default.
- W2904219651 creator A5009886562 @default.
- W2904219651 creator A5029495589 @default.
- W2904219651 creator A5031280773 @default.
- W2904219651 creator A5039233221 @default.
- W2904219651 creator A5042227235 @default.
- W2904219651 creator A5070684631 @default.
- W2904219651 date "2018-12-12" @default.
- W2904219651 modified "2023-09-30" @default.
- W2904219651 title "Neuropeptides SP and CGRP Underlie the Electrical Properties of Acupoints" @default.
- W2904219651 cites W1646069497 @default.
- W2904219651 cites W1965350130 @default.
- W2904219651 cites W1971964695 @default.
- W2904219651 cites W1983468956 @default.
- W2904219651 cites W1995491401 @default.
- W2904219651 cites W1996638593 @default.
- W2904219651 cites W2003706636 @default.
- W2904219651 cites W2007093069 @default.
- W2904219651 cites W2015232347 @default.
- W2904219651 cites W2035118482 @default.
- W2904219651 cites W2056885349 @default.
- W2904219651 cites W2057995908 @default.
- W2904219651 cites W2070737846 @default.
- W2904219651 cites W2074290145 @default.
- W2904219651 cites W2074923884 @default.
- W2904219651 cites W2100036723 @default.
- W2904219651 cites W2105721556 @default.
- W2904219651 cites W2138692697 @default.
- W2904219651 cites W2139528795 @default.
- W2904219651 cites W2142953265 @default.
- W2904219651 cites W2146863244 @default.
- W2904219651 cites W2149446930 @default.
- W2904219651 cites W2164958184 @default.
- W2904219651 cites W2167875991 @default.
- W2904219651 cites W2206582657 @default.
- W2904219651 cites W2213947373 @default.
- W2904219651 cites W2260712622 @default.
- W2904219651 cites W2289562567 @default.
- W2904219651 cites W2316939868 @default.
- W2904219651 cites W2323562172 @default.
- W2904219651 cites W2594069001 @default.
- W2904219651 cites W2766775334 @default.
- W2904219651 cites W3021088707 @default.
- W2904219651 doi "https://doi.org/10.3389/fnins.2018.00907" @default.
- W2904219651 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6299809" @default.
- W2904219651 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30618546" @default.
- W2904219651 hasPublicationYear "2018" @default.
- W2904219651 type Work @default.
- W2904219651 sameAs 2904219651 @default.
- W2904219651 citedByCount "18" @default.
- W2904219651 countsByYear W29042196512020 @default.
- W2904219651 countsByYear W29042196512021 @default.
- W2904219651 countsByYear W29042196512022 @default.
- W2904219651 countsByYear W29042196512023 @default.
- W2904219651 crossrefType "journal-article" @default.
- W2904219651 hasAuthorship W2904219651A5005652887 @default.
- W2904219651 hasAuthorship W2904219651A5009886562 @default.
- W2904219651 hasAuthorship W2904219651A5029495589 @default.
- W2904219651 hasAuthorship W2904219651A5031280773 @default.
- W2904219651 hasAuthorship W2904219651A5039233221 @default.
- W2904219651 hasAuthorship W2904219651A5042227235 @default.
- W2904219651 hasAuthorship W2904219651A5070684631 @default.
- W2904219651 hasBestOaLocation W29042196511 @default.
- W2904219651 hasConcept C118303440 @default.
- W2904219651 hasConcept C126322002 @default.
- W2904219651 hasConcept C134018914 @default.
- W2904219651 hasConcept C142724271 @default.
- W2904219651 hasConcept C163170386 @default.
- W2904219651 hasConcept C170493617 @default.
- W2904219651 hasConcept C2776089194 @default.
- W2904219651 hasConcept C2776533618 @default.
- W2904219651 hasConcept C2776914184 @default.
- W2904219651 hasConcept C2777649898 @default.
- W2904219651 hasConcept C2779540182 @default.
- W2904219651 hasConcept C2779627488 @default.
- W2904219651 hasConcept C42219234 @default.
- W2904219651 hasConcept C71924100 @default.
- W2904219651 hasConceptScore W2904219651C118303440 @default.
- W2904219651 hasConceptScore W2904219651C126322002 @default.
- W2904219651 hasConceptScore W2904219651C134018914 @default.
- W2904219651 hasConceptScore W2904219651C142724271 @default.
- W2904219651 hasConceptScore W2904219651C163170386 @default.
- W2904219651 hasConceptScore W2904219651C170493617 @default.
- W2904219651 hasConceptScore W2904219651C2776089194 @default.
- W2904219651 hasConceptScore W2904219651C2776533618 @default.
- W2904219651 hasConceptScore W2904219651C2776914184 @default.
- W2904219651 hasConceptScore W2904219651C2777649898 @default.
- W2904219651 hasConceptScore W2904219651C2779540182 @default.
- W2904219651 hasConceptScore W2904219651C2779627488 @default.
- W2904219651 hasConceptScore W2904219651C42219234 @default.
- W2904219651 hasConceptScore W2904219651C71924100 @default.
- W2904219651 hasLocation W29042196511 @default.
- W2904219651 hasLocation W29042196512 @default.
- W2904219651 hasLocation W29042196513 @default.
- W2904219651 hasLocation W29042196514 @default.
- W2904219651 hasOpenAccess W2904219651 @default.
- W2904219651 hasPrimaryLocation W29042196511 @default.
- W2904219651 hasRelatedWork W1964778255 @default.