FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904221477> ?p ?o ?g. }

• W2904221477 endingPage "68" @default.
• W2904221477 startingPage "59" @default.
• W2904221477 abstract "The neuropeptide somatostatin (SST) plays an important regulatory role in the proliferation of normal and neoplastic cells. Five subtypes of somatostatin receptors (SSTRs), SSTR1–SSTR5, have been identified in human tumours. The SSTR2 subtype is identified most commonly in meningiomas. Long half-life SST analogues are now recommended for the systemic treatment of unresectable or radiation-refractory recurrent human meningiomas. In this study, SSTR2 expression was evaluated in 46 canine meningiomas; in 21 cases this was by immunohistochemistry and in 25 cases by reverse transcriptase quantitative polymerase chain reaction (RT-qPCR). In addition, SSTR2 expression was evaluated by immunocytochemistry, western blotting and RT-qPCR on primary cell cultures prepared from two canine meningiomas. SSTR2 immunohistochemical expression was observed in 17/21 cases (81%), and SSTR2 mRNA expression was detected in 14/25 cases (56%). SSTR2 protein and gene expression were not significantly correlated with the tumour histological subtype or grade. Overall, meningothelial meningiomas showed constant and diffuse SSTR2 immunohistochemical expression and the highest SSTR2 gene expression level compared with other subtypes. A tendency for loss of SSTR2 in high-grade meningiomas was observed in both immunohistochemical and RT-qPCR studies. About 90% of cultured canine meningioma cells showed SSTR2 expression. In both of the meningioma cell cultures, SSTR2 expression was also detected by western blotting and RT-qPCR. This study demonstrates for the first time that canine meningioma expresses SSTR2 and that this expression is maintained in vitro. Our results, while preliminary, provide encouragement for further studies aimed at finding novel medical treatment strategies for canine meningioma, especially for tumours that are not surgically accessible." @default.
• W2904221477 created "2018-12-22" @default.
• W2904221477 creator A5005250341 @default.
• W2904221477 creator A5011070536 @default.
• W2904221477 creator A5037602712 @default.
• W2904221477 creator A5039994497 @default.
• W2904221477 creator A5049793385 @default.
• W2904221477 creator A5058979365 @default.
• W2904221477 creator A5078294450 @default.
• W2904221477 creator A5091460425 @default.
• W2904221477 date "2019-01-01" @default.
• W2904221477 modified "2023-10-02" @default.
• W2904221477 title "Somatostatin Receptor 2 Expression in Canine Meningioma" @default.
• W2904221477 cites W1584743295 @default.
• W2904221477 cites W1693130048 @default.
• W2904221477 cites W1694073840 @default.
• W2904221477 cites W1814723318 @default.
• W2904221477 cites W1963673993 @default.
• W2904221477 cites W1966535776 @default.
• W2904221477 cites W1967034772 @default.
• W2904221477 cites W1985057332 @default.
• W2904221477 cites W1988082636 @default.
• W2904221477 cites W1992353080 @default.
• W2904221477 cites W1995312162 @default.
• W2904221477 cites W1995842347 @default.
• W2904221477 cites W2004333510 @default.
• W2904221477 cites W2004465266 @default.
• W2904221477 cites W2004519055 @default.
• W2904221477 cites W2018522578 @default.
• W2904221477 cites W2023679122 @default.
• W2904221477 cites W2024533647 @default.
• W2904221477 cites W2027086621 @default.
• W2904221477 cites W2029041840 @default.
• W2904221477 cites W2035778488 @default.
• W2904221477 cites W2055043387 @default.
• W2904221477 cites W2062948407 @default.
• W2904221477 cites W2078406993 @default.
• W2904221477 cites W2080232093 @default.
• W2904221477 cites W2090394884 @default.
• W2904221477 cites W2093248557 @default.
• W2904221477 cites W2093507970 @default.
• W2904221477 cites W2107277218 @default.
• W2904221477 cites W2133125164 @default.
• W2904221477 cites W2144027745 @default.
• W2904221477 cites W2252793495 @default.
• W2904221477 cites W2366536035 @default.
• W2904221477 cites W2414436227 @default.
• W2904221477 cites W2562974917 @default.
• W2904221477 cites W2736836650 @default.
• W2904221477 cites W2753475110 @default.
• W2904221477 cites W392339088 @default.
• W2904221477 doi "https://doi.org/10.1016/j.jcpa.2018.11.002" @default.
• W2904221477 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30691608" @default.
• W2904221477 hasPublicationYear "2019" @default.
• W2904221477 type Work @default.
• W2904221477 sameAs 2904221477 @default.
• W2904221477 citedByCount "10" @default.
• W2904221477 countsByYear W29042214772019 @default.
• W2904221477 countsByYear W29042214772020 @default.
• W2904221477 countsByYear W29042214772021 @default.
• W2904221477 countsByYear W29042214772022 @default.
• W2904221477 countsByYear W29042214772023 @default.
• W2904221477 crossrefType "journal-article" @default.
• W2904221477 hasAuthorship W2904221477A5005250341 @default.
• W2904221477 hasAuthorship W2904221477A5011070536 @default.
• W2904221477 hasAuthorship W2904221477A5037602712 @default.
• W2904221477 hasAuthorship W2904221477A5039994497 @default.
• W2904221477 hasAuthorship W2904221477A5049793385 @default.
• W2904221477 hasAuthorship W2904221477A5058979365 @default.
• W2904221477 hasAuthorship W2904221477A5078294450 @default.
• W2904221477 hasAuthorship W2904221477A5091460425 @default.
• W2904221477 hasConcept C104317684 @default.
• W2904221477 hasConcept C126322002 @default.
• W2904221477 hasConcept C134018914 @default.
• W2904221477 hasConcept C142724271 @default.
• W2904221477 hasConcept C150008808 @default.
• W2904221477 hasConcept C153911025 @default.
• W2904221477 hasConcept C204232928 @default.
• W2904221477 hasConcept C2776297358 @default.
• W2904221477 hasConcept C2779160599 @default.
• W2904221477 hasConcept C32363146 @default.
• W2904221477 hasConcept C502942594 @default.
• W2904221477 hasConcept C54355233 @default.
• W2904221477 hasConcept C64980429 @default.
• W2904221477 hasConcept C71924100 @default.
• W2904221477 hasConcept C80115893 @default.
• W2904221477 hasConcept C85265743 @default.
• W2904221477 hasConcept C86803240 @default.
• W2904221477 hasConceptScore W2904221477C104317684 @default.
• W2904221477 hasConceptScore W2904221477C126322002 @default.
• W2904221477 hasConceptScore W2904221477C134018914 @default.
• W2904221477 hasConceptScore W2904221477C142724271 @default.
• W2904221477 hasConceptScore W2904221477C150008808 @default.
• W2904221477 hasConceptScore W2904221477C153911025 @default.
• W2904221477 hasConceptScore W2904221477C204232928 @default.
• W2904221477 hasConceptScore W2904221477C2776297358 @default.
• W2904221477 hasConceptScore W2904221477C2779160599 @default.
• W2904221477 hasConceptScore W2904221477C32363146 @default.

• next