FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904229054> ?p ?o ?g. }

• W2904229054 endingPage "1323" @default.
• W2904229054 startingPage "1313" @default.
• W2904229054 abstract "BCR-ABL+acute lymphoblastic leukemia (ALL) in adults has a poor prognosis with allogeneic stem cell transplantation (SCT) considered the best curative option for suitable patients. We here characterize the curative potential of BH3-mimetics differentially targeting mitochondrial BCL2-family members using a combination therapy approach with dexamethasone and tyrosine kinase inhibitors targeting BCR-ABL. In BCR-ABL + ALL BH3-mimetics act by redistribution of mitochondrial activator BIM, which is strongly required for cytotoxicity of the BCL2-specific BH3-mimetic ABT-199, tyrosine kinase inhibitors (TKIs) and dexamethasone. BIM expression is enhanced by dexamethasone and TKIs and both synergize with ABT-199 in BCR-ABL + ALL. Triple combinations with ABT-199, dexamethasone and TKIs efficiently attenuate leukemia progression both in tissue culture and in primary cell xenotransplantation models. Notably, the dasatinib-containing combination led to treatment- and leukemia-free long-term survival in a BCR-ABL + mouse model. Finally, response to BH3-mimetics can be predicted for individual patients in a clinically relevant setting. These data demonstrate curative targeted and chemotherapy-free pharmacotherapy for BCR-ABL + ALL in a preclinical model. Clinical evaluation, in particular for patients not suitable for allogeneic SCT, is warranted." @default.
• W2904229054 created "2018-12-22" @default.
• W2904229054 creator A5000286275 @default.
• W2904229054 creator A5013197730 @default.
• W2904229054 creator A5013231760 @default.
• W2904229054 creator A5022378009 @default.
• W2904229054 creator A5032880179 @default.
• W2904229054 creator A5037477222 @default.
• W2904229054 creator A5048696331 @default.
• W2904229054 creator A5048836242 @default.
• W2904229054 creator A5053578678 @default.
• W2904229054 creator A5054358107 @default.
• W2904229054 creator A5059166426 @default.
• W2904229054 creator A5066349732 @default.
• W2904229054 creator A5084000618 @default.
• W2904229054 creator A5084381587 @default.
• W2904229054 date "2018-12-13" @default.
• W2904229054 modified "2023-10-17" @default.
• W2904229054 title "Optimized induction of mitochondrial apoptosis for chemotherapy-free treatment of BCR-ABL+acute lymphoblastic leukemia" @default.
• W2904229054 cites W1607777232 @default.
• W2904229054 cites W1970961784 @default.
• W2904229054 cites W1986981274 @default.
• W2904229054 cites W1991213319 @default.
• W2904229054 cites W2017069405 @default.
• W2904229054 cites W2037148599 @default.
• W2904229054 cites W2056166587 @default.
• W2904229054 cites W2059500638 @default.
• W2904229054 cites W2063898537 @default.
• W2904229054 cites W2074677800 @default.
• W2904229054 cites W2087671302 @default.
• W2904229054 cites W2089360398 @default.
• W2904229054 cites W2091134276 @default.
• W2904229054 cites W2094274818 @default.
• W2904229054 cites W2103064975 @default.
• W2904229054 cites W2116521328 @default.
• W2904229054 cites W2125657361 @default.
• W2904229054 cites W2160075057 @default.
• W2904229054 cites W2164265350 @default.
• W2904229054 cites W2166342674 @default.
• W2904229054 cites W2172242534 @default.
• W2904229054 cites W2192121806 @default.
• W2904229054 cites W2284945982 @default.
• W2904229054 cites W2300592511 @default.
• W2904229054 cites W2419714211 @default.
• W2904229054 cites W2516164871 @default.
• W2904229054 cites W2534349779 @default.
• W2904229054 cites W2563700816 @default.
• W2904229054 cites W2620804057 @default.
• W2904229054 cites W2737907117 @default.
• W2904229054 cites W2800133359 @default.
• W2904229054 doi "https://doi.org/10.1038/s41375-018-0315-6" @default.
• W2904229054 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6756054" @default.
• W2904229054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30546081" @default.
• W2904229054 hasPublicationYear "2018" @default.
• W2904229054 type Work @default.
• W2904229054 sameAs 2904229054 @default.
• W2904229054 citedByCount "17" @default.
• W2904229054 countsByYear W29042290542020 @default.
• W2904229054 countsByYear W29042290542021 @default.
• W2904229054 countsByYear W29042290542022 @default.
• W2904229054 countsByYear W29042290542023 @default.
• W2904229054 crossrefType "journal-article" @default.
• W2904229054 hasAuthorship W2904229054A5000286275 @default.
• W2904229054 hasAuthorship W2904229054A5013197730 @default.
• W2904229054 hasAuthorship W2904229054A5013231760 @default.
• W2904229054 hasAuthorship W2904229054A5022378009 @default.
• W2904229054 hasAuthorship W2904229054A5032880179 @default.
• W2904229054 hasAuthorship W2904229054A5037477222 @default.
• W2904229054 hasAuthorship W2904229054A5048696331 @default.
• W2904229054 hasAuthorship W2904229054A5048836242 @default.
• W2904229054 hasAuthorship W2904229054A5053578678 @default.
• W2904229054 hasAuthorship W2904229054A5054358107 @default.
• W2904229054 hasAuthorship W2904229054A5059166426 @default.
• W2904229054 hasAuthorship W2904229054A5066349732 @default.
• W2904229054 hasAuthorship W2904229054A5084000618 @default.
• W2904229054 hasAuthorship W2904229054A5084381587 @default.
• W2904229054 hasBestOaLocation W29042290541 @default.
• W2904229054 hasConcept C126322002 @default.
• W2904229054 hasConcept C170493617 @default.
• W2904229054 hasConcept C203014093 @default.
• W2904229054 hasConcept C2777583451 @default.
• W2904229054 hasConcept C2777938653 @default.
• W2904229054 hasConcept C2778461978 @default.
• W2904229054 hasConcept C2778729363 @default.
• W2904229054 hasConcept C2779536868 @default.
• W2904229054 hasConcept C2779675984 @default.
• W2904229054 hasConcept C2911091166 @default.
• W2904229054 hasConcept C42362537 @default.
• W2904229054 hasConcept C502942594 @default.
• W2904229054 hasConcept C71924100 @default.
• W2904229054 hasConceptScore W2904229054C126322002 @default.
• W2904229054 hasConceptScore W2904229054C170493617 @default.
• W2904229054 hasConceptScore W2904229054C203014093 @default.
• W2904229054 hasConceptScore W2904229054C2777583451 @default.
• W2904229054 hasConceptScore W2904229054C2777938653 @default.
• W2904229054 hasConceptScore W2904229054C2778461978 @default.
• W2904229054 hasConceptScore W2904229054C2778729363 @default.
• W2904229054 hasConceptScore W2904229054C2779536868 @default.

• next